Evaluating retardation and physicochemical properties of co-ground mixture of Na- diclofenac with magnesium stearate

Influence of coating material on the flowability and dissolution of dry-coated fine ibuprofen powders

“…This contradicts previous reports, that co-grinding drug powders with the hydrophobic MgSt retards the dissolution of the drug in powder mixtures by preventing wetting and water penetration (Javadzadeh et al, 2012;Nokhodchi et al, 2009). In this study, we believe the increased dissolution rate from the MgSt-mechanofused powder is due to the enhanced powder de-agglomeration.…”

“…However, there is an extensive historical concern that the hydrophobic properties of some dry coating agents such as magnesium stearate will retard drug dissolution in the powder mixture when over-blended or co-ground (Javadzadeh et al, 2012;Nokhodchi et al, 2009) . Over blending of magnesium stearate is also known to have a negative effect on tableting behaviour (Shah and Mlodozeniec, 1977;Strickland Jr et al, 1956;Wang et al, 2010).…”

A Review on Liquisolid Systems

“…With various drugs it could be observed that the release rates are directly proportional to the fraction of the drug molecularly dispersed (F M ) in the liquid formulation [3,5,11,14] . F M is defined by Spireas as the ratio between the drug's solubility (S d ) in the liquid vehicle and the actual drug concentration (C d ) in this vehicle carried by each system [9] .…”

“…Hence, a dry, free flowing, and compressible powder is obtained. [1] Liquisolid compacts of poorly soluble drugs containing a drug solution or drug suspension in a solubilising vehicle show enhanced drug release due to one or more of the following reasons, an increased surface area of drug available for release, an increased aqueous solubility of the drug, and an improved wettability of the drug particles [3][4][5][6] . Subsequently, this improved drug release may result in a higher drug absorption from the gastrointestinal tract and thus, an improvement in oral bioavailability [7,8] .…”

Mineral–vegetal co-milling: An effective process to improve lignocellulosic biomass fine milling and to increase interweaving between mixed particles

“…In recent years, co-milling has received increasing attention especially in the field of polymer composites (Le Bolay and Molina-Boisseau, 2014;Lu and Wang, 2004;Zapata-Massot et al, 2004) or drug formulation (Javadzadeh et al, 2012;Williams et al, 1999). These studies generally compare the physical properties (particle size distribution, particle shape, powder density ...) of co-milled powders with a mixture of the two parent materials separately ground (Barzegar-Jalali et al, 2010;.…”