Evaluating pulmonary toxicity of Shuang–Huang–Lian in vitro and in vivo

Han, Rong; Ye, Jun-Xiao; Quan, Li-Hui; Liu, Chunyu; Yang, Ming

doi:10.1016/j.jep.2011.03.060

Cited by 10 publications

(6 citation statements)

References 11 publications

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“…3-hydeoxybutyric acid, choline, phosphocholine, valine, and leucine, were also detected on the antipyretic action in SHLI treatment group. These findings highlight the pharmacological characteristics and safety evaluation of SHLI [29], [30]. Furthermore, the further experiments should be taken fully into account a dose and time dependent manners of SHLI.…”

Section: Discussionmentioning

confidence: 69%

Plasma Metabolomic Profiling to Reveal Antipyretic Mechanism of Shuang-Huang-Lian Injection on Yeast-Induced Pyrexia Rats

Gao

Guo

et al. 2014

PLoS ONE

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Shuang-huang-lian injection (SHLI) is a famous Chinese patent medicine, which has been wildly used in clinic for the treatment of acute respiratory tract infection, pneumonia, influenza, etc. The existing randomized controlled trial (RCT) studies suggested that SHLI could afford a certain anti-febrile action. However, seldom does research concern the pharmacological mechanisms of SHLI. In the current study, we explored plasma metabolomic profiling technique and selected potential metabolic markers to reveal the antipyretic mechanism of SHLI on yeast-induced pyrexia rat model using UPLC-Q-TOF/MS coupled with multivariate statistical analysis and pattern recognition techniques. We discovered a significant perturbance of metabolic profile in the plasma of fever rats and obvious reversion in SHLI-administered rats. Eight potential biomarkers, i.e. 1) 3-hydeoxybutyric acid, 2) leucine, 3) 16∶0 LPC, 4) allocholic acid, 5) vitamin B2, 6) Cys-Lys-His, 7) 18∶2 LPC, and 8) 3-hydroxychola-7, 22-dien-24-oic acid, were screened out by OPLS-DA approach. Five potential perturbed metabolic pathways, i.e. 1) valine, leucine, and isoleucine biosynthesis, 2) glycerophospholipid metabolism, 3) ketone bodies synthesis and degradation, 4) bile acid biosynthesis, and 5) riboflavin metabolism, were revealed to relate to the antipyretic mechanisms of SHLI. Overall, we investigated antipyretic mechanisms of SHLI at metabolomic level for the first time, and the obtained results highlights the necessity of adopting metabolomics as a reliable tool for understanding the holism and synergism of Chinese patent drug.

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Section: Discussionmentioning

confidence: 69%

Plasma Metabolomic Profiling to Reveal Antipyretic Mechanism of Shuang-Huang-Lian Injection on Yeast-Induced Pyrexia Rats

Gao

Guo

et al. 2014

PLoS ONE

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“…However, a recent study has demonstrated that baicalin can activate the transforming growth factor-β (TGF-β)/Smad signaling pathway in a dose-dependent manner, induce the Smad3 acetylation (via interaction of Smad3 with transcriptional coactivator p300), and reduce the phosphorylation of AMPK (a metabolic master kinase) that results in kidney injury and fibrosis at higher doses (Cai et al 2017). Han et al (2011) evaluated in vitro and in vivo the pulmonary toxicity of shuang-huang-lian preparation, with a long history for treating respiratory tract infection. A report indicated that the injection of the lyophilized powder of shuanghuang-lian prepared with honeysuckle (Lonicera caprifolium L., Caprifoliaceae), S. baicalensis roots, and the fruits of Forsythia suspensa (Thunb.)…”

Section: Toxicitymentioning

confidence: 99%

Antiviral Properties of Baicalin: a Concise Review

Liang

Cheng

et al. 2021

Rev. Bras. Farmacogn.

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Baicalin is one of the bioactive flavonoid glycosides isolated from the dried root of Scutellaria baicalensis Georgi, Lamiaceae, with antiviral properties. In recent years, the antiviral activity of baicalin has been widely investigated to explore its molecular mechanism of action. In this mini-review, the molecular mechanisms of action of baicalin as an antiviral agent are evaluated, which included three categories: the inhibition or stimulation of JAK/STAT, TLRs, and NF-κB pathways; up or down modulation of the expression levels of IFN, IL, SOCS1/3, PKR protein, Mx1 protein, and AP-1 protein; and inhibition of cell apoptosis caused by virus infection. In addition, clinical studies of baicalin are also discussed. This literature search suggested that baicalin can serve as a potential candidate for the development of a novel broad-spectrum antiviral drug.

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“…Further investigations needed to be done to make it clear. Shuanghuanglian injection is usually used for the treatment of respiratory infection and has been one of the top selling herbal medicine products over the last decade 17 . However, Shuanghuanglian injection often causes severe allergic reaction in the clinic [18][19][20] .…”

Section: Determination Of 5-ht In Allergic Guinea Pig Plasmamentioning

confidence: 99%