Evaluating Progestogens for Preventing Preterm Birth International Collaborative (EPPPIC): Meta-analysis of Individual Participant Data From Randomised Controlled Trials

Abstract

methyldopa group and 22.5% in the nifedipine group (P < 0.001). The reduction of preeclampsia was from 48.8% to 26.5% in the methyldopa group and 28.7% in the nifedipine group (P < 0.001). In turn, there were reductions in preterm birth and neonatal intensive care unit admissions as well (Pregnancy Hypertens 2019;17:54-58). In addition, there is a large ongoing trial in the United States that is randomizing women to treatment versus no treatment that should finish over the next couple of years. Unfortunately, we will not know from either of these studies whether we should treat patients within the new category of 130-139 systolic or 80-89 diastolic. However, if the larger study produces outcomes similar to the smaller trial above and given the increased rates of perinatal morbidity seen in the current study, I would suggest that careful consideration of treating these individuals.-ABC)