Evaluating outcomes associated with revised fluoroquinolone breakpoints for Enterobacterales urinary tract infections: A retrospective cohort study

Benavides, Taylor M.; Aden, James K; Giancola, Stephanie E.

doi:10.1007/s10096-022-04428-1

Cited by 1 publication

(1 citation statement)

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“…However, this study did not include information about the class of antibiotic used for the comparisons. Studies conducted with quinolones have shown that inappropriate therapy may affect the efficacy of these antimicrobial agents [ 13 , 14 ], with a relative higher risk of recurrence. Our study showed a similar rate of readmission secondary to a relapsing or recurring episode of pyelonephritis, but since this was a retrospective study, an information bias could be responsible for some missing endpoints (i.e., patients that were hospitalized in other hospitals that were not able to be identified as recurrent infection).…”

Section: Discussionmentioning

confidence: 99%

Effect of Inappropriate Treatment in Hospitalized Patients with Pyelonephritis Treated with Cefuroxime: A Cohort Study

Cortés,

Sierra,

Sánchez

2024

Antibiotics

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The aim of this study was to evaluate the effect of inappropriate therapy in adult patients with community-acquired pyelonephritis caused by Escherichia coli receiving empirical treatment with cefuroxime during hospital stay and readmission. A retrospective cohort study was performed. Inappropriate treatment was considered treatment for a nonsusceptible isolate according to the results of the urine culture. Adjustment for confounding factors was performed with propensity score-derived inverse probability of treatment weighting. Between 2013 and 2020, 747 patients were included, 102 (13.7%) of whom received inappropriate therapy. Compared to appropriate therapy, inappropriate therapy was associated with a shorter length of stay in the adjusted analysis (Hazard Ratio = 0.34; 95% CI = 0.23–0.49). After 735 patients were discharged from the hospital, 66 were readmitted in the following 30 days. In comparison with appropriate therapy, inappropriate antimicrobial therapy was not related to readmission (OR 1.47; 95% CI = 0.35–2.79). Inappropriate therapy was not related to a longer hospital stay or readmission due to pyelonephritis after adjusting for confounders and covariates.

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Section: Discussionmentioning

confidence: 99%