This study was conducted to evaluate the effect of supplementation Oreganum aetheroleum essential oil on reproductive performance in sows and growth performance of their offspring of weaning pig. 12 sows (Landrace × Yorkshire) were randomly assigned within parities to 1 of 3 dietary treatments to give 4 replicates per treatment. Dietary treatments were as follows: 1) CON (basal diet) 2) ANT (basal diet + Efrotomycin 0.08%) and 3) ORE (basal diet + Oreganum aetheroleum essential oil 0.05%), EXP. 1, diets were fed from d 107 of gestation to weanling. EXP. 2, diets were fed from after weaning to 3 weeks. In the Exp.1, no significant difference (p > 0.05) was observed in sow's average parity, sow backfat thickness, the number of piglets, feed intake of sows, the average of piglet weight, and piglet survival ratio between CON, ANT, and ORE treatments. Besides, in the Exp. 2, the inclusion of efrotomycin and Oreganum aetheroleum essential oil in the diets significantly (p < 0.05) increased final body weight, ADG, ADFI, and G/F in weanling pigs. In addition, weanling pigs fed ANT and ORE diets led to decrease the number of weanling pigs with diarrhea as well as fecal score. In conclusion, supplementation of efrotomycin and Oreganum aetheroleum essential oil enhanced growth performance, and decreased the number of weanling pigs with diarrhea and fecal score. However, no significant effect on grow performance was observed in sow and piglet.