Evaluating of bone healing around porous coated titanium implant and potential systematic bias on the traditional sampling method

Prediction of the intramembranous tissue formation during perisprosthetic healing with uncertainties. Part 1. Effect of the variability of each biochemical factor

“…The osteoblast cells promote bone formation and mineralization by depositing new bone tissue on the implant surface and surrounding bone (Davies 2003). The growth factors regulate cell proliferation and stimulate bone matrix formation (Conover 2000) in the presence of mechanical factors coming from the implant design and joint loads (Babiker et al 2013). Early numerical models of a bone healing process were based on pure mechanical approaches and focused on the mechanical behaviour while simplifying the biochemical and time effects (Carter et al 1988;Viceconti et al 2000).…”