Evaluating Non-Conventional Chitosan Sources for Controlled Release of Risperidone

Garcinuño, Sara; Aranaz, Inmaculada; Civera, Concepción; Arias, Concepción; Acosta, Niuris

doi:10.3390/polym14071355

Cited by 8 publications

(4 citation statements)

References 47 publications

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“…Chitosan, a chitin-derived linear cationic polysaccharide, is a natural, hydrophilic, non-allergenic, biocompatible, non-toxic and biodegradable product obtained from chitin of cuttlebone [112,113]. Chemical modification of chitosan has been frequently carried out to prepare derivatives with applications in many fields including pharmaceutics [112,[114][115][116]. For example, a low-molecular weight sulfated chitosan holds immense potential in carbohydrate-based pharmaceuticals [117], and it is a potential inhibitor of white spot syndrome virus proteins [118].…”

Section: Pharmacological Activity and Pharmaceutical Applicationsmentioning

confidence: 99%

The Use of Shells of Marine Molluscs in Spanish Ethnomedicine: A Historical Approach and Present and Future Perspectives

González,

Vallejo

2023

Pharmaceuticals

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Since ancient times, the shells of marine molluscs have been used as a therapeutic and/or prophylactic resource. In Spain, they were part of practical guides for doctors or pharmacists until the 19th century. In general, seashells were prepared by dissolving in vinegar and were part of plasters or powders used as toothpaste, or to treat dyspepsia, heartburn and leprosy. Thus, the nacre or mother-of-pearl of various molluscs was regularly used in the Royal Colleges of Surgery and in hospitals during the times of the Cortes of Cadiz, as a medicine in galenic preparations based on powders. In contemporary Spanish ethnomedicine, seashells, with a high symbolic value, have been used as an amulet to prevent cracks in the breasts and promote their development during lactation, to avoid teething pain in young children, to eliminate stains on the face or to cure erysipelas. But, as in other countries, products derived from seashells have also been empirically applied. The two resources used traditionally have been the cuttlebone, the internal shell of cuttlefish and the nacre obtained from the external shells of some species. Cuttlebone, dried and pulverised, has been applied externally to cure corneal leukoma and in dental hygiene. In the case of nacre, a distinction must be made between chemical and physical remedies. Certain seashells, macerated in lemon juice, were used in coastal areas to remove spots on the face during postpartum. However, the most common practice in Spain mainland was to dissolve mother-of-pearl buttons in lemon juice (or vinegar). The substance thus obtained has been used to treat different dermatological conditions of the face (chloasma, acne), as well as to eliminate freckles. For the extraction of foreign bodies in the eyes, a very widespread traditional remedy has been to introduce small mother-of-pearl buttons under the lid. These popular remedies and practices are compared with those collected in classic works of medicine throughout history, and data on the pharmacological activity and pharmaceutical applications of the products used are provided. The use of cuttlebone powders is supported by different works on anti-inflammatory, immune-modulatory and/or wound healing properties. Nacre powder has been used in traditional medicines to treat palpitations, convulsions or epilepsy. As sedation and a tranquilisation agent, nacre is an interesting source for further drug development. Likewise, nacre is a biomaterial for orthopaedic and other tissue bioengineering applications. This article is a historical, cultural and anthropological view that can open new epistemological paths in marine-derived product research.

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Section: Pharmacological Activity and Pharmaceutical Applicationsmentioning

confidence: 99%

The Use of Shells of Marine Molluscs in Spanish Ethnomedicine: A Historical Approach and Present and Future Perspectives

González,

Vallejo

2023

Pharmaceuticals

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“…XG is a porous, architectured material emanating from varying drying strategies of wet gels . Thus, the enchanting and peculiar attributes of these porous materials are garnered from the peculiar exibility as well as resilience of the sol-gel fabrication procedure, garnered in synergy with either ambient drying (X-G) or supercritically a liated drying (A-G) [81][82][83][84][85][86][87][88][89][90][91][92][93][94][95][96][97][98][99][100]. As already elucidated, these substrates have been fabricated from varying precursors, like carbon, silica, and biopolymeric entities and possessing differing biological, physical, chemical, and mechanical, attributes, relative to varying parameters, including precursoral substrates, solvent medium, as well as drying parameters [101][102][103][104][105][106][107][108][109][110][111][112][113][114][115][116][117][118][119][120].…”

Section: Challenges and Future Perspectivesmentioning

confidence: 99%

Characterization and Fabrication of Xerogel Polymeric Nanocomposites and Multifunctional Applications

Idumah

2022

Preprint

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Xerogel (X-G)@polymeric nanocomposites are hybrid nanomaterials constituted of xerogels (X-Gs) synergized with polymeric materials with enclosed nanoparticulates in either physical or covalently inclined cross-linking with one another and/or with the nano-substrates. X-G@biopolymeric bionanocomposites are hybrid bionanomaterials constructed by synergizing biopolymeric matrices with dispersed organic or inorganic nanoparticulates with improved properties for multifunctional applications. Hence, this paper elucidates novel trends in synthesis, construction, characterizations, properties and multifunctional applications of X-G@polymeric nanocomposites.

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“…Atypical antipsychotic medications have become the most commonly used drugs for treating schizophrenia [ 4 ]. Among these medications, risperidone is a widely utilized medication, primarily exerting its antipsychotic effects through the blocking of the dopamine D2 and serotonin 5-HT2A receptors, though it carries a higher incidence of extrapyramidal symptoms and hyperprolactinemia adverse reactions [ 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Population Pharmacodynamic Models of Risperidone on PANSS Total Scores and Prolactin Levels in Schizophrenia

Huang,

Zhang,

et al. 2024

Pharmaceuticals

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Currently, research predominantly focuses on evaluating clinical effects at specific time points while neglecting underlying patterns within the treatment process. This study aims to analyze the dynamic alterations in PANSS total scores and prolactin levels in patients with schizophrenia treated with risperidone, along with the influencing covariates. Using data from an 8-week randomized, double-blind, multicenter clinical trial, a population pharmacodynamic model was established for the PANSS total scores of and prolactin levels in patients treated with risperidone. The base model employed was the Emax model. Covariate selection was conducted using a stepwise forward inclusion and backward elimination approach. A total of 144 patients were included in this analysis, with 807 PANSS total scores and 531 prolactin concentration values. The PANSS total scores of the patients treated with risperidone decreased over time, fitting a proportionally parameterized sigmoid Emax model with covariates including baseline score, course of the disease, gender, plasma calcium ions, and lactate dehydrogenase levels. The increase in prolactin levels conformed to the ordinary Emax model, with covariates encompassing course of the disease, gender, weight, red blood cell count, and triglyceride levels. The impacts of the baseline scores and the course of the disease on the reduction of the PANSS scores, as well as the influence of gender on the elevation of prolactin levels, each exceeded 20%. This study provides valuable quantitative data regarding PANSS total scores and prolactin levels among patients undergoing risperidone treatment across various physiological conditions.

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Evaluating Non-Conventional Chitosan Sources for Controlled Release of Risperidone

Cited by 8 publications

References 47 publications

The Use of Shells of Marine Molluscs in Spanish Ethnomedicine: A Historical Approach and Present and Future Perspectives

The Use of Shells of Marine Molluscs in Spanish Ethnomedicine: A Historical Approach and Present and Future Perspectives

Characterization and Fabrication of Xerogel Polymeric Nanocomposites and Multifunctional Applications

Population Pharmacodynamic Models of Risperidone on PANSS Total Scores and Prolactin Levels in Schizophrenia

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