Evaluating Muscle Symptoms

Petty, Richard

doi:10.1136/jnnp.74.suppl_2.ii38

Cited by 4 publications

(4 citation statements)

References 4 publications

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“…Breathlessness can develop suddenly over hours and these patients should be closely monitored with regular measurements of their forced vital capacity. 2,[4][5][6] In our patient the progression of weakness also occurred craniocaudal, starting from the eyelids to trunk and limb muscles. There was mild weakness of intercostal muscles and diaphragm and she felt mild difficulty with breathing.…”

Section: Discussionsupporting

confidence: 51%

Juvenile myasthenia gravis

Gunawan¹,

Saharso²

2007

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Section: Discussionsupporting

confidence: 51%

Juvenile myasthenia gravis

Gunawan¹,

Saharso²

2007

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“…Reduced physical activity in people with neuromuscular disorders is often associated with higher levels of muscle pain, further loss of muscle function, and/or a generalised sense of fatigue. 101 Therapies that directly promote an increase in muscle mass could potentially be of benefit in ALS; however, the mechanism of intervention is critically important. To be truly beneficial, interventions must address underlying factors that contribute to muscle wasting.…”

Section: Muscle Pathologymentioning

confidence: 99%

“…This would further impair function and quality of life. Reduced physical activity in people with neuromuscular disorders is often associated with higher levels of muscle pain, further loss of muscle function, and/or a generalised sense of fatigue 101 …”

Section: Amyotrophic Lateral Sclerosismentioning

confidence: 99%

Ghrelin as a treatment for amyotrophic lateral sclerosis

Ngo

Wang

Henderson

et al. 2021

J Neuroendocrinology

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Ghrelin is a 28-amino acid hormone that is predominantly secreted by oxyntic glands of the stomach and gastrointestinal tract. 1 Generally recognised for stimulating growth hormone (GH) secretion 1 and as a key orexigenic regulator of food intake, 2-5 there is growing evidence to highlight wider-ranging biological actions of ghrelin. 6 These actions underscore the potential for the use of ghrelin, and/or the activation of ghrelin-mediated pathways, as a possible therapeutic strategy for conditions that are associated with impairments in appetite and the loss of GH secretion, as well as complex diseases that are associated with impairments in metabolism. In this review, we briefly summarise the biological actions of ghrelin and consider how modulation of the actions of ghrelin could be used to mitigate disease processes central to amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease that currently lacks effective treatments.

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“…Watching a person walking on their toes or heels, hopping, or walking up-stairs is more revealing than just a couch-based assessment. 37…”

Section: Introductionmentioning

confidence: 99%

Muscle biopsy: what and why and when?

Walters

Baborie

2020

Pract Neurol

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Skeletal muscle biopsy remains an important investigative tool in the diagnosis of a variety of muscle disorders. Traditionally, someone with a limb-girdle muscle weakness, myopathic changes on electrophysiology and raised serum creatine kinase (CK) would have a muscle biopsy. However, we are living through a genetics revolution, and so do all such patients still need a biopsy? When should we undertake a muscle biopsy in patients with a distal, scapuloperoneal or other patterns of muscle weakness? When should patients with myositis, rhabdomyolysis, myalgia, hyperCKaemia or a drug-related myopathy have a muscle biopsy? What does normal muscle histology look like and what changes occur in neurogenic and myopathic disorders? As with Kipling’s six honest serving men, we hope that by addressing these issues we can all become more confident about when to request a muscle biopsy and develop clearer insights into muscle pathology.

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Evaluating Muscle Symptoms

Cited by 4 publications

References 4 publications

Juvenile myasthenia gravis

Juvenile myasthenia gravis

Ghrelin as a treatment for amyotrophic lateral sclerosis

Muscle biopsy: what and why and when?

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