Evaluating methods to create protein functionalized catanionic vesicles

Zayka, Paul; Parr, Brendan; Robichaud, Hannah; Hickey, Skyler; Topping, Amber; Holt, Elizabeth M.; Watts, David; Soto, Nicholas; Stein, Daniel C.; DeShong, Philip

doi:10.1039/d2sm01205g

Cited by 4 publications

(1 citation statement)

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“…Vesicles are structures characterized by their spherical or elliptical shape, composed of one or more bilayers with internal cavities formed by amphiphiles [ 16 ]. They have found extensive applications as encapsulation and delivery systems [ 17 , 18 , 19 , 20 , 21 , 22 ]. While the formation of vesicles typically requires the addition of salts or other additives into surfactant micellar solutions [ 23 , 24 , 25 ], there are cases where vesicles spontaneously form upon dilution of the micellar phase of catanionic surfactants.…”

Section: Introductionmentioning

confidence: 99%

The Spontaneous Vesicle–Micelle Transition in a Catanionic Surfactant System: A Chemical Trapping Study

et al. 2023

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Typically, the formation of vesicles requires the addition of salts or other additives to surfactant micelles. However, in the case of catanionic surfactants, unilamellar vesicles can spontaneously form upon dilution of the micellar solutions. Our study explores the intriguing spontaneous vesicle-to-micelle transition in catanionic surfactant systems, specifically cetyltrimethyl ammonium bromide (CTAB) and sodium octylsulfonate (SOS). To gain insights into the changes occurring at the interface, we employ a chemical trapping method to characterize variations in the molarities of sulfonate headgroups, water, and bromide ions during the transition. Our findings reveal the formation of ion pairs between the cationic component of CTAB and the anionic component of SOS, leading to tight interfacial packing in CTAB/SOS solutions. This interfacial packing promotes vesicle formation at low surfactant concentrations. Due to the significant difference in critical micelle concentration (cmc) between CTAB and SOS, an increase in the stoichiometric surfactant concentration results in a substantial rise in the SOS-to-CTAB ratio within the interfacial region. This enrichment of SOS in the aggregates triggers the transition from vesicles to micelles. Overall, our study may shed new light on the design of morphologies in catanionic and other surfactant systems.

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