Evaluating Matrix Effects in the Analysis of Polycyclic Aromatic Hydrocarbons from Food: Can These Interferences Be Neglected for Isotope Dilution?

Belo, Renata França Cassimiro; Pissinatti, Rafael; Souza, Scheilla Vitorino Carvalho de; Junqueira, Roberto Gonçalves

doi:10.1007/s12161-016-0706-0

Cited by 8 publications

(1 citation statement)

References 32 publications

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“…Sample collection and preparation are essential to be able to quantify and analyze the PAH content due to the complex nature of the matrices involved in foods, which might influence the evaluation results (Belo, Pissinatti, de Souza, & Junqueira, 2017). Normally, sample preparation includes extraction, separation, clean‐up, and concentration steps with an attempt to maximize recovery yield of the target analytes and minimize negative interferences of impurities.…”

Section: Methods For Analyzing Pahs In Foodmentioning

confidence: 99%

Analytical chemistry, formation, mitigation, and risk assessment of polycyclic aromatic hydrocarbons: From food processing to in vivo metabolic transformation

Zhang

Chen

Zhang

2021

Comp Rev Food Sci Food Safe

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Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in the air, oils, water, and food products we encounter every day. Among these exposures, food consumption is a major route of PAH exposure for nonsmokers. The PAH dietary exposure levels vary among different countries; however, many studies have shown PAH exposure to be highly concerning to human health. The levels of PAH contamination in food are mainly influenced by processing procedures and cooking methods, and they could be attenuated by modifying cooking procedures and adding antioxidant‐rich marinades. Several PAHs have toxic, mutagenic, and carcinogenic properties. The PAH benzo[a]pyrene (BaP) is particularly regarded as carcinogenic. There are three major metabolism pathways for PAHs, and the final products can bind to DNA, thus exerting mutagenic effects. Biological monitoring through the use of biomarkers is necessary for comprehensive and accurate risk assessments of human PAH exposure. It is important to reduce dietary PAH exposure and to implement reasonable and effective risk management strategies to reduce PAH levels in food to improve public health.

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Section: Methods For Analyzing Pahs In Foodmentioning

confidence: 99%

Analytical chemistry, formation, mitigation, and risk assessment of polycyclic aromatic hydrocarbons: From food processing to in vivo metabolic transformation

Zhang

Chen

Zhang

2021

Comp Rev Food Sci Food Safe

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Purity determination of a new antifungal drug candidate using quantitative ¹H NMR spectroscopy: Method validation and comparison of calibration approaches

Franco

Braga

Oliveira

et al. 2019

Magnetic Reson in Chemistry

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Quantitative nuclear magnetic resonance (qNMR) is an analytical technique that offers numerous advantages in pharmaceutical applications including minimum sample preparation and rapid data collection times with no need for response factor corrections, being a powerful tool for assaying drug content in both drug discovery and early drug development. In the present work, we have applied qNMR, using both the internal standard and the electronic reference to access in vivo concentrations 2 calibration methods, to assess the purity of RI76, a novel antifungal drug candidate. NMR acquisition and processing parameters were optimized in order to obtain spectra with intense, well‐resolved signals of completely relaxed nuclei. The analytical method was validated following current guidelines, demonstrating selectivity, linearity, accuracy, precision, and robustness. The calibration approaches were statistically compared, and no significant difference was observed when comparing the obtained results and their dispersion in terms of relative standard deviation. The proposed qNMR method may, therefore, be used for both qualitative and quantitative assessments of RI76 in early drug development and for characterization of this compound.

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Low-Solvent Multiphase Electroextraction of Caprylic Acid in Cider and Mead Samples Followed by LC–MS/MS Quantification

Resende

Freitas²,

Orlando³

et al. 2022

Food Anal. Methods

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Evaluating Matrix Effects in the Analysis of Polycyclic Aromatic Hydrocarbons from Food: Can These Interferences Be Neglected for Isotope Dilution?

Cited by 8 publications

References 32 publications

Analytical chemistry, formation, mitigation, and risk assessment of polycyclic aromatic hydrocarbons: From food processing to in vivo metabolic transformation

Analytical chemistry, formation, mitigation, and risk assessment of polycyclic aromatic hydrocarbons: From food processing to in vivo metabolic transformation

Purity determination of a new antifungal drug candidate using quantitative ¹H NMR spectroscopy: Method validation and comparison of calibration approaches

Low-Solvent Multiphase Electroextraction of Caprylic Acid in Cider and Mead Samples Followed by LC–MS/MS Quantification

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Evaluating Matrix Effects in the Analysis of Polycyclic Aromatic Hydrocarbons from Food: Can These Interferences Be Neglected for Isotope Dilution?

Cited by 8 publications

References 32 publications

Analytical chemistry, formation, mitigation, and risk assessment of polycyclic aromatic hydrocarbons: From food processing to in vivo metabolic transformation

Analytical chemistry, formation, mitigation, and risk assessment of polycyclic aromatic hydrocarbons: From food processing to in vivo metabolic transformation

Purity determination of a new antifungal drug candidate using quantitative 1H NMR spectroscopy: Method validation and comparison of calibration approaches

Low-Solvent Multiphase Electroextraction of Caprylic Acid in Cider and Mead Samples Followed by LC–MS/MS Quantification

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Purity determination of a new antifungal drug candidate using quantitative ¹H NMR spectroscopy: Method validation and comparison of calibration approaches