Evaluating maintenance electroconvulsive therapy in Bipolar Disorders: 3-year mirror-image study

Madero, Santiago; Anmella, Gerard; Sagué-Vilavella, María; Pons, Mercedes Boncompte; Giménez, Anna; Murru, Andréa; Gómez-Ramiro, Marta; Gil-Badenes, Joaquín; Ríos, José; Bioque, Miquel; Vieta, Eduard; Benabarre, Antonio

doi:10.1016/j.jad.2021.10.052

Cited by 9 publications

(3 citation statements)

References 39 publications

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“…Specifically, individuals in both the psychotic disorder group, encompassing schizophrenia and schizoaffective disorder, as well as the mood disorders group, comprising major depressive disorder and bipolar disorder, exhibited a statistically significant reduction in the aforementioned parameters. These results are consistent with previous studies that have demonstrated the effectiveness of continuation-maintenance ECT in reducing the risk of relapse and readmission rates for patients with schizophrenia, 20,21 bipolar disorder, 22,23 and major depressive disorder, 10,24 and schizoaffective disorder. 23,25 The reduction in admission days and hospitalizations in patients undergoing continuation-maintenance ECT can be attributed to several factors.…”

Section: Discussionsupporting

confidence: 92%

Effect of Continuation-Maintenance Electroconvulsive Therapy on Hospitalization: A Retrospective Mirror-Image Study

Sombatcharoen-non,

Yamnim,

Jullagate

et al. 2023

NDT

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Objective To examine the effect of continuation-maintenance electroconvulsive therapy (ECT) on psychiatric hospitalization in Thai patients. Methods This retrospective mirror-image study reviewed medical records of Thai patients who received continuation-maintenance ECT at Ramathibodi Hospital, Bangkok, between September 2013 and December 2022. The initiation of continuation-maintenance ECT served as the index event, establishing pre-initiation and post-initiation periods. The primary outcome measured the differences in admissions and admission days before and after continuation-maintenance ECT. Results Forty-seven patients were included in the study, with diagnoses of schizophrenia (38.3%), schizoaffective disorder (21.3%), and bipolar disorder (19.1%) being the most common. The mean (standard deviation; SD) age was 44.6 (12.2) years. The total duration that patients received continuation-maintenance ECT was 53 ± 38.2 months. Following the initiation of ECT, there was a significant reduction in the median (interquartile range) number of hospitalizations for all patients (2 [2] versus 1 [2], p < 0.001), as well as for the psychotic disorder group (2 [2] versus 1 [2.75], p = 0.006) and the mood disorder group (2 [2] versus 1 [2], p = 0.02). Moreover, there was a significant reduction in the median (interquartile range) length of admission days for all patients after the initiation of continuation-maintenance ECT (66 [69] versus 20 [53], p < 0.001). Specifically, the psychotic disorder group (64.5 [74] versus 15.5 [62], p = 0.02) and mood disorder group (74 [57] versus 20 [54], p = 0.008) demonstrated statistically significant decreases in admission days. Conclusion Continuation-maintenance ECT may be an effective treatment option for reducing hospitalizations and admission days in patients with various psychiatric diagnoses. However, the study also highlights the need to carefully consider the potential adverse effects of ECT in clinical decision-making.

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Section: Discussionsupporting

confidence: 92%

Effect of Continuation-Maintenance Electroconvulsive Therapy on Hospitalization: A Retrospective Mirror-Image Study

Sombatcharoen-non,

Yamnim,

Jullagate

et al. 2023

NDT

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“…As shown in recent findings in a small cohort, patients receiving mECT are less likely to experience a relapse [36]. It has been shown that this method reduces hospitalization in patients with BD and may also stabilize their mood [37 ▪ ].…”

Section: Non-invasive Approachesmentioning

confidence: 73%

Neurostimulation as a treatment for mood disorders in patients: recent findings

Afshari

Belzung

2022

Current Opinion in Psychiatry

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Purpose of reviewThe use of neurostimulation to treat mood disorders dates back to the 1930s. Recent studies have explored various neurostimulation methods aimed at both restoring a healthy brain and reducing adverse effects in patients. The purpose of this review is to explore the most recent hypotheses and clinical studies investigating the effects of stimulating the brain on mood disorders.Recent findingsRecent work on brain stimulation and mood disorders has focused mainly on three aspects: enhancing efficacy and safety by developing new approaches and protocols, reducing treatment duration and chances of relapse, and investigating the physiological and pathological mechanisms behind treatment outcomes and possible adverse effects.This review includes some of the latest studies on both noninvasive techniques, such as transcranial magnetic stimulation, magnetic seizure therapy, transcranial direct current stimulation, transcranial alternating current stimulation, electroconvulsive treatment, and invasive techniques, such as deep brain stimulation and vagus nerve stimulation.SummaryBrain stimulation is widely used in clinical settings; however, there is a lack of understanding about its neurobiological mechanism. Further studies are needed to understand the neurobiology of brain stimulation and how it can be used to treat mood disorders in their diversity, including comorbidities with other illnesses.

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“…Electroconvulsive therapy responses rapidly and is able to show corresponding clinical effects in a short time, so it can be used in emergency situations. As for the efficacy of ECT in the treatment of BD, studies have shown that compared with the pre-ECT treatment, the number of psychiatric hospitalization days and hospitalization times of patients receiving treatment have significantly decreased [16], and most clinical experiences have shown that ECT has a significant effect in the treatment of BD. However, compared with extensive clinical experience, there is still less scientific evidence for the effect of ECT in the treatment of BD, the relevant trial samples are small, and the selected patients themselves are biased.…”

Section: Electroconvulsive Therapymentioning

confidence: 99%

The Treatment of Bipolar Disorder

2024

TMBLS

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As a relatively large class of neurological diseases, bipolar has always been an important object of research and exploration by scientists. When bidirectional patients develop the disease, they are aggressive and a great burden for their families. Therefore, how to treat bipolar has been a hot topic. Current treatments for bipolar include medication, psychotherapy, and physiotherapy. Drug therapy includes mood stabilizers, antidepressants, anticonvulsants, antipsychotics and so on. Psychotherapy is aimed not only at the patient, but also with his or her spouse and relatives. Treatment modalities include psychoanalytic therapy, analytic psychotherapy, cognitive behavioral therapy, suggestive therapy, and supportive therapy. However, different treatment modalities have certain limitations. For example, drugs have certain side effects and may cause complications during treatment. Psychotherapy is more limited by the patient. Physical therapy may cause memory impairment, nausea, headaches, etc. This review is about current treatment modalities for bipolar and their limitations.

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Evaluating maintenance electroconvulsive therapy in Bipolar Disorders: 3-year mirror-image study

Cited by 9 publications

References 39 publications

Effect of Continuation-Maintenance Electroconvulsive Therapy on Hospitalization: A Retrospective Mirror-Image Study

Effect of Continuation-Maintenance Electroconvulsive Therapy on Hospitalization: A Retrospective Mirror-Image Study

Neurostimulation as a treatment for mood disorders in patients: recent findings

The Treatment of Bipolar Disorder

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