Evaluating Ion Accumulation and Storage in Traveling Wave Based Structures for Lossless Ion Manipulations

Kwantwi-Barima, Pearl; Garimella, Sandilya V. B.; Attah, Isaac K.; Ibrahim, Yehia M.

doi:10.1021/jasms.3c00348

Cited by 4 publications

(4 citation statements)

References 35 publications

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“…While previous discussions of charge reduction have focused on its relationship to contamination, it is important to recognize that a second factor, experimental time scale, is also significant. The unique geometry of TW-SLIM has enabled the accumulation of considerably dense ion populations, separation over expansive pathlengths, and the implementation of unique and insightful experiments. ,, However, it is important to recognize that many of these advancements have coincided with pushing the time scale of SLIM experiments well beyond what is typical for stacked-ring ion guides. Stated differently, SLIM experiments occur at pressures (2–4 Torr) and for time periods (hundreds and thousands of milliseconds) which have yet to be thoroughly explored by the IMS and MS communities.…”

Section: Resultsmentioning

confidence: 99%

“…When considering strategies to limit the time ions spend in SLIM, it is important to recall that ions often spend significant time within SLIM undergoing on-board accumulation as a means of boosting sensitivity. Though the benefits of this approach are well-documented, ,, those analyzing labile or highly dynamic species may consider alternative approaches such as the use of ion “dumps” or multiplexing techniques. Approaches that can inject ions via the redirection of a continuous ion beam as opposed to a more traditional gating would not only reduce the time ions spend on the board but would also remove some ambiguity regarding the total time an ion spends within SLIM …”

Section: Discussionmentioning

confidence: 99%

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Altering Conformational States of Dynamic Ion Populations using Traveling Wave Structures for Lossless Ion Manipulations

Kinlein,

Clowers

2024

Anal. Chem.

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With its capacity to store and translate ions across considerable distances and times, traveling wave structures for lossless ion manipulations (TW-SLIM) provide the foundation to expand the scope of ion mobility spectrometry (IMS) experiments. While promising, the dynamic electric fields and consequential ionneutral collisions used to realize extensive degrees of separation have a considerable impact on the empirical results and the fundamental interpretation of observed arrival time distributions. Using a custom-designed set of TW-SLIM boards (∼9 m) coupled with a time-of-flight mass spectrometer (SLIM-ToF), we detail the capacity to systematically alter the gas-phase distribution of select peptide conformers. In addition to discussing the role chargetransfer may play in TW-SLIM experiments that occur at extended time scales, the ability of the SLIM-ToF to perform tandem IMS was leveraged to confirm that both the compact and elongated conformers of bradykinin 2+ undergo interconversion within the SLIM. Storage experiments in which ions are confined within SLIM using static potential wells suggest that factors aside from TW-induced ion motion contribute to interconversion. Further investigation into this matter suggests that the use of radio frequency (RF) fields to confine ions within SLIM may play a role in ion heating. Aside from interconversion, storage experiments also provide insight into charge transfer behavior over the course of extended periods. The results of the presented experiments suggest that considerations should be taken when analyzing labile species and inform strategies for the TW-SLIM design and method development.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Altering Conformational States of Dynamic Ion Populations using Traveling Wave Structures for Lossless Ion Manipulations

Kinlein,

Clowers

2024

Anal. Chem.

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“…19 Another potential problem are space-charging effects, which are due to the repulsion of charged ions with the same polarity. This pheomenon can lead to a decrease in accuracy, sensitivity and resolution of the mass 32,33 (and ion mobility 34,35 ) measurements, although in practice this is usually not a problem for mass. High concentrations lead more likely to oversaturation of the detector, 36 which decreases their lifetime, and also means that instruments have to be cleaned more frequently due to the contaminations with neutrals from solution.…”

Section: Sample Preparationmentioning

confidence: 99%

Modern Electrospray Ionization Mass Spectrometry Techniques for the Characterisation of Supramolecules and Coordination Compounds

Geue

2024

Preprint

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Mass spectrometry is routinely used for myriad applications in clinical, industrial, and research laboratories worldwide. Developments in the areas of ionisation sources, high-resolution mass analysers, tandem mass spectrometry, and ion mobility have significantly extended the repertoire of mass spectrometrists, however for coordination compounds and supramolecules, mass spectrometry remains underexplored and arguably underappreciated. Here, the reader is guided through different tools of modern electrospray ionization mass spectrometry that are suitable for larger inorganic complexes. All steps, from sample preparation and technical details to data analysis and interpretation are discussed. The main target audience of this tutorial are synthetic chemists as well as technicians/mass spectrometrists with little experience in characterising labile inorganic compounds.

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“…IMS separations in SLIM are performed by traveling waves, while ion confinement is achieved using radio frequency (RF) in conjunction with direct current (DC) potentials. Various key designs in SLIM and the flexibility of the TW application have enabled separations over extended path lengths (e.g., 13 m), 90° turns, ion trapping, − multilevel, , and multipass operations to provide unprecedented high-resolution ion mobility separations (e.g., resolving power of 1860 was demonstrated). , The planar nature of SLIM designs allows the implementation of many layouts to take advantage of the high-resolution capability of the device with a relatively small increase in the instrument footprint. The key to such a compact footprint is SLIM use of serpentine paths incorporating 90° turns and two-way ion switches.…”

Section: Introductionmentioning

confidence: 99%

Ion Mobility Separations Using Cocentric Architecture

Kwantwi-Barima,

Hollerbach,

Attah

et al. 2024

J. Am. Soc. Mass Spectrom.

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Ion mobility separations, especially using drift tube ion mobility spectrometers, are usually performed in linear channels, which can have a large footprint when extended to achieve higher resolving powers. In this work, we explored the performance of an ion mobility device with a curved architecture, which can have a more compact form. The cocentric ion mobility spectrometer (CoCIMS) manipulates ions between two cocentric surfaces containing a serpentine track. The mobility separation inside the CoCIMS is achieved using traveling waveforms (TWs). We initially evaluated the device using ion trajectory simulations using SIMION, which indicated that when ions traveled circularly inside the CoCIMS they resulted in similar resolving powers and transmitted m/z range as traveling in a straight path. We then performed experimental validation of the CoCIMS in conjunction with a TOF MS. The CoCIMS was made of two flexible printed circuit board materials folded into cocentric cylinders separated by a gap of 2.8 mm. The device was about 50 mm diameter ×152 mm long and provided 1.846 m of serpentine path length. Three sets of mixtures (Agilent tune mixture, tetraalkylammonium salts, and an eight-peptide mixture) and four traveling waveform profiles (square, sine, triangle, and sawtooth) were used. The sawtooth TW profile produced a slightly higher resolving power for the Agilent tuning mixture and tetraalkylammonium ions. The average resolving power for Agilent tune mixture ions ranged from 37 (using sawtooth TW) to 27 (using square TW). The average resolving powers ranged from 45 (sawtooth TW) to 31 (square TW) for tetraalkylammonium ions. The resolving power of the peptide mixture ions was similar among the four TW profiles and ranged from 51 to 56. The average percent error in TW CCS for the peptide mixture ions was about 0.4%. The new device showed promising results, but improvements are needed to further increase the resolving power.

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Evaluating Ion Accumulation and Storage in Traveling Wave Based Structures for Lossless Ion Manipulations

Cited by 4 publications

References 35 publications

Altering Conformational States of Dynamic Ion Populations using Traveling Wave Structures for Lossless Ion Manipulations

Altering Conformational States of Dynamic Ion Populations using Traveling Wave Structures for Lossless Ion Manipulations

Modern Electrospray Ionization Mass Spectrometry Techniques for the Characterisation of Supramolecules and Coordination Compounds

Ion Mobility Separations Using Cocentric Architecture

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