Evaluating health outcome metrics and their connections to air pollution and vulnerability in Southern California's Coachella Valley

Miao, Yanli; Porter, William C.; Schwabe, K.; LeComte-Hinely, Jenna

doi:10.1016/j.scitotenv.2022.153255

Cited by 11 publications

(4 citation statements)

References 55 publications

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“…(70) Interestingly, but perhaps not surprisingly, GSLD PM 2.5 was substantially more cytotoxic to human lung cells in vitro, and more pro-in ammatory in mice. Meanwhile, another saline lake dust, SSD, for which adverse human health effects have been described, (14,15,17,18,20,21) exhibited overlapping activities with, and seemingly greater potency than GSLD. Remarkably, both GSLD and SSD appeared to engage TRPV1 and TRPV3 as a basis for stimulating IL6 and IL8 expression by HBEC3-KT cells, intimating the potential of perhaps therapeutically modulating these receptors as a way to mitigate the acute and possibly longer-term effects of GSLD and similar saline lake dusts.…”

Section: Discussionmentioning

confidence: 99%

“…(12,13) Other examples include Owens Lake and the Salton Sea in California. (14)(15)(16)(17)(18)(19)(20)(21) In the summer of 2022, the GSL reached historic lows, exposing expansive areas of dry lakebed that are prone to resuspension as respirable dust (GSLD) during high wind events. In 2020, the GSL playa was estimated to contribute ~ 23-34% of dust ux along the Wasatch front.…”

Section: Introductionmentioning

confidence: 99%

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Pro-Inflammatory Effects of Inhaled Great Salt Lake Dust Particles

Cowley,

Deering-Rice,

Lamb

et al. 2024

Preprint

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Background: Climatological shifts and human activities have decimated lakes worldwide. Water in the Great Salt Lake, Utah, USA is at near record lows which has increased risks for exposure to windblown dust from dried lakebed sediments. Formal studies evaluating the health effects of inhaled Great Salt Lake dust (GSLD) have not been performed despite the belief that the dust is harmful. The objectives of this study were to illustrate windblown dust events, assess the impact of inhaled dust on the lungs, and to identify mechanisms that could contribute to the effects of GSLD in the lungs. Results: An animation, hourly particle and meteorological data, and images illustrate the impact of dust events on the Salt Lake Valley/Wasatch front airshed. Great Salt Lake sediment and PM2.5 contained metals, lipopolysaccharides, natural and anthropogenic chemicals, and bacteria. Inhalation and oropharyngeal delivery of PM2.5 triggered neutrophilia and the expression of mRNA for Il6, Cxcl1, Cxcl2, and Muc5ac in mouse lungs, was more potent than coal fly ash (CFA) PM2.5, and more cytotoxic to human airway epithelial cells (HBEC3-KT) in vitro. Induction of IL6 and IL8 was replicated in vitro using HBEC3-KT and THP-1 cells. For HBEC3-KT cells, IL6 induction was variably attenuated by EGTA/ruthenium red, the TLR4 inhibitor TAK-242, and deferoxamine, while IL8 was attenuated by EGTA/ruthenium red. Inhibition of mRNA induction by EGTA/ruthenium red suggested roles for transition metals, calcium, and calcium channels as mediators of the responses. Like CFA, GSLD and a similar dust from the Salton Sea in California, activated human TRPA1, M8, and V1. However, only inhibition of TRPV1, TRPV3, and a combination of both channels impacted cytokine mRNA induction in HBEC3-KT cells. Responses of THP1 cells were partially mediated by TLR4 as opposed to TRP channels and mice expressing a “humanized” form of TRPV1 exhibited greater neutrophilia when exposed to GSLD via inhalation. Conclusions: This study suggests that windblown dust from Great Salt Lake and similar lake sediments could pose a risk to humans via mechanisms including the activation of TRPV1/V3, TLR4, and possibly oxidative stress.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pro-Inflammatory Effects of Inhaled Great Salt Lake Dust Particles

Cowley,

Deering-Rice,

Lamb

et al. 2024

Preprint

View full text Add to dashboard Cite

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“…3,4) 사회경제적 취약지역에 거주하는 인구집단은 오염시설과의 근접성, 녹지 자연, 교통 등 주거 외 환경뿐만 아 니라 건물의 노후화, 실내 공기오염, 화학물질, 온습도, 위생상 태 등의 주거 내 환경으로 인하여 환경유해인자 노출에 보다 취 약할 수 있고, 5) 이와 같이 지리적 취약성을 가진 취약집단의 환 경유해인자 노출이 높게 나타난다는 연구결과가 상당수 보고 되고 있다. 3,[6][7][8][9] 여러 환경유해물질 중 카드뮴은 광산이나 제련 등 지역사회 오염원 배출과 관계가 깊으므로 10) 환경오염의 공간적 취약성과 관계를 가지게 되며 저소득이나 소수민족 공동체의 주거지역에 서 더 높은 노출수준을 보이는 것으로 전해진다. 11) 국내 연구들 도 사회경제적 수준이 낮은 집단의 카드뮴 노출수준이 높은 것 으로 보고한 바 있다.…”

Section: 서 론unclassified

Cadmium Exposure and Renal Damage in Individuals with Low Socioeconomic Status in Environmentally Vulnerable Areas

Cho

Jin

Kang

et al. 2023

J Environ Health Sci

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Background: Few studies have assessed exposure to chemicals in the context of environmental vulnerability with a focus on exposure among populations living in certain geographical areas.Objectives: This study aimed to investigate cadmium exposure levels and kidney damage indices in environmentally and socioeconomically vulnerable populations, with further subgrouping according to economic status.Methods: Four areas were selected to represent geographical vulnerability (two environmentally vulnerable populations and two socioeconomically vulnerable populations). Among them, population groups with lower socioeconomic status (SES) were separately classified. Urinary cadmium (UCd), beta 2 -microglobulin (β 2 -MG), and N-acetyl-β-D-glucosaminidase (NAG) levels were analyzed in samples from 245 residents of these four areas.Results: Geometric means of concentrations of UCd (0.97~2.02 µg/g creatinine) in all selected populations (N, 245; mean age, 67.8~70.9 years old) were higher than the national reference values (0.39 for adults and 0.78 µg/g creatinine for people in their 60s). Participants with a lower SES had higher UCd and NAG concentrations than did non-low SES participants. In the lower SES group, there was a significant association between UCd and NAG concentrations; however, there was no such correlation in the non-low SES group. Conclusions:Consistent with the findings of previous studies evaluating chemical exposure and associated health effects in specific populations, the findings of this study suggest that individuals with a low SES may be more vulnerable to exposure and related health effects.

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“…17 Additional burdens these communities face include insufficient housing availability and poor infrastructure, language barriers, asthma, and impaired water quality. 18,19 These factors put residents at risk of respiratory damage and diseases like asthma and COVID-19. 20 In fact, Imperial County held both the highest infection and mortality rates per capita in California from COVID-19 throughout the height of the pandemic.…”

Section: Introductionmentioning

confidence: 99%

Nitrogen Isotopes Reveal High NOx Emissions from Arid Agricultural Soils in the Salton Sea Air Basin

Lieb,

Walters,

Maldonado

et al. 2024

Preprint

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Air quality management commonly aims to mitigate emissions of oxides of nitrogen (NOx) from combustion, reducing ozone and particulate matter pollution. Despite such efforts, regulations have recently proven ineffective in rural areas like the Salton Sea Air Basin of Southern California, which routinely violates air quality standards. With $2 billion in annual agricultural sales and low population density, air quality in the region is likely influenced by year-round farming. We conducted NOx source apportionment using nitrogen stable isotopes of ambient NO2, which indicate a substantial contribution of soil-emitted NOx. The soil source strength was estimated based on the mean δ15N-NOx from each emission category in the California Air Resources Board's NOx inventory. Our annual average soil emission estimate for the air basin was 11.4 ± 4 tons/d, representing ~ 30% of the extant NOx inventory, 10× larger than the state’s inventory. Therefore, the impact of soil NOx in agricultural regions must be re-evaluated.

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Evaluating health outcome metrics and their connections to air pollution and vulnerability in Southern California's Coachella Valley

Cited by 11 publications

References 55 publications

Pro-Inflammatory Effects of Inhaled Great Salt Lake Dust Particles

Pro-Inflammatory Effects of Inhaled Great Salt Lake Dust Particles

Cadmium Exposure and Renal Damage in Individuals with Low Socioeconomic Status in Environmentally Vulnerable Areas

Nitrogen Isotopes Reveal High NOx Emissions from Arid Agricultural Soils in the Salton Sea Air Basin

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