Evaluating DNA tests of motherless cases using a Philippine genetic database

Abstract

W was higher than W(-mother) in the 50 families. However, the existence of unrelated individuals in the NCR database that randomly matched at seven STR loci and that has W(-mother) values greater than 99.0 percent highlights the need for greater precaution when dealing with motherless cases.

The problem of single parent/child paternity analysis—Practical results involving 336 children and 348 unrelated men

“…However, our own practical data and simulated or empirical data from other work groups demonstrate that single parent/child cases should be analyzed very carefully [4,5,11]. Regarding our results, the probability to wrongly include an unrelated man seems to be rather high.…”

“…In a theoretical approach regarding 10,000 comparisons (16 analyzed STRs), no child/unrelated man pair without excluding STRs could be found [5]. Ungria et al reported on 195 random-matching pairs out of 5253 comparisons [11] analyzing only seven STR loci. A further calculation with our program considering only seven STRs demonstrated 1498 child/unrelated man pairs without mismatches (1.3% of all comparisons).…”

Parentage verification of Valle del Belice dairy sheep using multiplex microsatellite panel

“…The misidentification rates are high compared to other livestock species (Crawford et al, 1993;Laughlin et al, 2003;Weller et al, 2004;Siwek and Knol, 2010), indicating the need to improve the identification system and genealogical data collection. The obtained non-exclusion probabilities and paternity test results indicated that this microsatellite panel is suitable for parentage testing animals from moderately inbred and structured populations, even when subjects are related (De Ungria et al, 2002;von Wurmb-Schwark et al, 2006;Wenk et al, 2006;Scarpetta et al, 2007), and could be used for pedigree reconstruction of Valle del Belice breed.…”

Development of a pentaplex X-chromosomal short tandem repeat typing system and population genetic studies

“…The father, however, carried allele 51 at DXS8377. Since paternity of this man had previously been confirmed at eight autosomal STR loci [23], the mismatch between father and daughter is assumed to be due to the deletion of a single repeat unit (51 to 50) during meiosis. This assumption requires confirmation, but a mutation is made likely by the trimeric repeat structure of DXS8377, which makes it more prone to mutations than loci with tetrameric repeats [24].…”