Evaluating different concentrations of hydrogen peroxide in an automated room disinfection system

Murdoch, L.E.; Bailey, L. W.; Banham, E.; Watson, Fergus; Adams, Nicholas M.; Chewins, John

doi:10.1111/lam.12607

Cited by 25 publications

(26 citation statements)

References 8 publications

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“…A >6-log reduction was achieved throughout the chamber. Murdoch et al [108] 2016 Laboratory enclosure…”

Section: H 2 O 2 Vapormentioning

confidence: 99%

“…against a wide range of nosocomial pathogens including C. difficile spores, MRSA, VRE, A. baumannii, and norovirus surrogates [84,91,[101][102][103][104][105][106], though efficacy may be reduced by high microbial loading and the presence of organic soil [82,91,103,107]. An in vitro study established a dose-response relationship between the concentration of hydrogen peroxide used in an HPV system and the microbiological efficacy [108]. This is helpful in understanding why aHP systems, which use a lower concentration of hydrogen peroxide, are less effective than HPV/VHP systems, which use a higher concentration of hydrogen peroxide.…”

Section: Pulsed-xenon Uv (Px-uv)mentioning

confidence: 99%

See 1 more Smart Citation

An overview of automated room disinfection systems: When to use them and how to choose them

Otter

Yezli

Barbut

et al. 2020

Decontamination in Hospitals and Healthcare

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“…A >6-log reduction was achieved throughout the chamber. Murdoch et al [108] 2016 Laboratory enclosure…”

Section: H 2 O 2 Vapormentioning

confidence: 99%

Section: Pulsed-xenon Uv (Px-uv)mentioning

confidence: 99%

An overview of automated room disinfection systems: When to use them and how to choose them

Otter

Yezli

Barbut

et al. 2020

Decontamination in Hospitals and Healthcare

View full text Add to dashboard Cite

“…The decontamination efficiency ranged from 3.68 log for the liquid solution without additive ( S1 ), to 4.47 log for the liquid solution with all additives ( S3 ). The decontamination kinetic of liquid solutions on spores adherent to the coupon can be seen in Figure 3 , with the lines for first-order kinetic-model ( Murdoch et al, 2016 ). The equation of these lines enabled the determination of the inactivation coefficients for each treatment at “room temperature” (equal 293.15 K and 20°C).…”

Section: Resultsmentioning

confidence: 99%

New Biocide Foam Containing Hydrogen Peroxide for the Decontamination of Vertical Surface Contaminated With Bacillus thuringiensis Spores

Toquin

Faure²,

Orange

et al. 2018

Front. Microbiol.

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Despite scientific advances, bacterial spores remain a major preoccupation in many different fields, such as the hospital, food, and CBRN-E Defense sector. Although many disinfectant technologies exist, there is a lack for the decontamination of difficult to access areas, outdoor sites, or large interior volumes. This study evaluates the decontamination efficiency of an aqueous foam containing hydrogen peroxide, with the efficiency of disinfectant in the liquid form on vertical surfaces contaminated by Bacillus thurengiensis spores. The decontamination efficiency impact of the surfactant and stabilizer agents in the foam and liquid forms was evaluated. No interferences were observed with these two chemical additives. Our results indicate that the decontamination kinetics of both foam and liquid forms are similar. In addition, while the foam form was as efficient as the liquid solution at 4°C, it was even more so at 30°C. The foam decontamination reaction follows the Arrhenius law, which enables the decontamination kinetic to be predicted with the temperature. Moreover, the foam process used via spraying or filling is more attractive due to the generation of lower quantity of liquid effluents. Our findings highlight the greater suitability of foam to decontaminate difficult to access and high volume facilities compared to liquid solutions.

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“…Ventilation was stopped in the model at 10:00 h, and the emission from the NTD was assumed to begin. The emissions were set to provide the approximate concentrations reported in the literature for NTD use: 25 ppm for ozone, 73,74 1000 ppm for formaldehyde, 30,31,33 100‐500 ppm for H 2 O 2, 47,75 and 3000 and 350 ppm for OClO (to reflect two commonly used concentrations) 30,76 . This required emission rates of 0.01 ppm/s to generate 25 ppm of O 3 , 0.5 ppm/s for 1000 ppm of HCHO, 0.3 ppm/s for 500 ppm of H 2 O 2 , and 0.8 and 0.1 ppm/s to deliver 3000 and 350 ppm of OClO (see Supporting Information).…”

Section: Methodsmentioning

confidence: 99%

Photolysis‐driven indoor air chemistry following cleaning of hospital wards

et al. 2020

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Effective cleaning techniques are essential for the sterilization of rooms in hospitals and industry. No-touch devices (NTDs) that use fumigants such as hydrogen peroxide (H 2 O 2), formaldehyde (HCHO), ozone (O 3), and chlorine dioxide (OClO) are a recent innovation. This paper reports a previously unconsidered potential consequence of such cleaning technologies: the photochemical formation of high concentrations of hydroxyl radicals (OH), hydroperoxy radicals (HO 2), organic peroxy radicals (RO 2), and chlorine radicals (Cl) which can form harmful reaction products when exposed to chemicals commonly found in indoor air. This risk was evaluated by calculating radical production rates and concentrations based on measured indoor photon fluxes and typical fumigant concentrations during and after cleaning events. Sunlight and fluorescent tubes without covers initiated photolysis of all fumigants, and plastic-covered fluorescent tubes initiated photolysis of only some fumigants. Radical formation was often dominated by photolysis of fumigants during and after decontamination processes. Radical concentrations were predicted to be orders of magnitude greater than background levels during and immediately following cleaning events with each fumigant under one or more illumination condition. Maximum predicted radical concentrations (1.3 × 10 7 molecule cm −3 OH, 2.4 ppb HO 2 , 6.8 ppb RO 2 and 2.2 × 10 8 molecule cm −3 Cl) were much higher than baseline concentrations. Maximum OH concentrations occurred with O 3 photolysis, HO 2 with HCHO photolysis, and RO 2 and Cl with OClO photolysis. Elevated concentrations may persist for hours after NTD use, depending on the air change rate and air composition. Products from reactions involving radicals could significantly decrease air quality when disinfectants are used, leading to adverse health effects for occupants.

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Evaluating different concentrations of hydrogen peroxide in an automated room disinfection system

Cited by 25 publications

References 8 publications

An overview of automated room disinfection systems: When to use them and how to choose them

An overview of automated room disinfection systems: When to use them and how to choose them

New Biocide Foam Containing Hydrogen Peroxide for the Decontamination of Vertical Surface Contaminated With Bacillus thuringiensis Spores

Photolysis‐driven indoor air chemistry following cleaning of hospital wards

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