<p>The COVID-19 pandemic and related
shutdowns have caused changes in everyday activities for many people, and signs
of those changes are present in the chemical signatures of sewage sludge
produced during the pandemic. We analyzed primary sewage sludge samples from a
wastewater treatment plant in New Haven, CT USA collected between March 19 and
June 30, 2020. This time period encompassed the first wave of the COVID-19
pandemic, the initial statewide stay at home order, and the first phase of reopening.
We used liquid chromatography coupled with high resolution mass spectrometry and
targeted and suspect screening strategies to identify contaminants in the
sludge. We and found evidence of increasing opioid, cocaine, and antidepressant
use, as well as upward trends in chemicals used in disinfectants and sunscreens
during the study period. Benzotriazole, an anti-corrosion chemical associated
with traffic pollution, decreased through the stay-at-home period, and
increased during reopening. Hydroxychloroquine, a drug that received
significant attention for its potential to treat COVID-19, had elevated concentrations
in the week following the implementation of the United States Emergency Use
Authorization. Our results directly relate to nationwide reports of increased
demand for fentanyl, antidepressants, and other medications, as well as reports
of increased drug overdose deaths during the pandemic. Though wastewater surveillance during the
pandemic has largely focused on measuring SARS-CoV-2 RNA concentrations,
chemical analysis can also show trends that are important for revealing the public
and environmental health effects of the pandemic. </p>