Evaluating Concussion in Sport: A Case for Magnetoencephalography

Fibel, Kenton H.; Cardinale, Nicholas; Nichols, Sharon L.; Trikha, Rishi; Huang, Mingxiong; Achar, Suraj

doi:10.4172/2324-9080.1000155

Cited by 1 publication

(3 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, MEG bypasses the hemodynamic response entirely by directly measuring the magnetic fields induced by neuronal electrical activity in the brain. [6][7][8][9] While EEG is similarly a more direct measure of neuronal activity than fMRI, the electrical signals are contaminated by interference from the conductive and inductive tissues of the brain, skull, and the scalp. The magnetic fields detected by MEG are not affected by these conductive and inductive effects and thereby maintain better signal purity.…”

Section: Discussionmentioning

confidence: 99%

“…The magnetic fields detected by MEG are not affected by these conductive and inductive effects and thereby maintain better signal purity. 6,7 Recent advances, including higher sensor density and enhanced source reconstruction techniques, have improved the spatial resolution of MEG relative to EEG and are comparable with those of fMRI. 7,10 Altogether, its high sensitivity and ability to localize pathologic magnetic signals generated by injured brain tissue, even with minimal changes in neuropsychologic testing, make MEG well-suited to assess changes in brain function related to sports-related concussion.…”

Section: Discussionmentioning

confidence: 99%

“…7,10 Altogether, its high sensitivity and ability to localize pathologic magnetic signals generated by injured brain tissue, even with minimal changes in neuropsychologic testing, make MEG well-suited to assess changes in brain function related to sports-related concussion. 4,6,11 Several resting-state MEG-based connectivity analyses have revealed alterations in the brain connectivity profiles of concussed subjects and those with mild traumatic brain injury (mTBI). 5,12,13 Various analytic approaches including amplitude envelope correlations and phase-locking estimates have been used in the past to derive connectivity metrics.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Alterations in the Magnetoencephalography Default Mode Effective Connectivity following Concussion

Reddy

Davenport

et al. 2021

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

BACKGROUND AND PURPOSE: Magnetoencephalography is sensitive to functional connectivity changes associated with concussion. However, the directional influences between functionally related regions remain unexplored. In this study, we therefore evaluated concussion-related magnetoencephalography-based effective connectivity changes within resting-state default mode network regions. MATERIALS AND METHODS:Resting-state magnetoencephalography was acquired for 8 high school football players with concussion at 3 time points (preseason, postconcussion, postseason), as well as 8 high school football players without concussion and 8 age-matched controls at 2 time points (preseason, postseason). Time-series from the default mode network regions were extracted, and effective connectivity between them was computed for 5 different frequency bands. The default mode network regions were grouped into anterior and posterior default mode networks. The combined posterior-to-anterior and anterior-to-posterior effective connectivity values were averaged to generate 2 sets of values for each subject. The effective connectivity values were compared using a repeated measures ANOVA across time points for the concussed, nonconcussed, and control groups, separately.RESULTS: A significant increase in posterior-to-anterior effective connectivity from preseason to postconcussion (corrected P value ¼ .013) and a significant decrease in posterior-to-anterior effective connectivity from postconcussion to postseason (corrected P value ¼ .028) were observed in the concussed group. Changes in effective connectivity were only significant within the delta band. Anterior-to-posterior connectivity demonstrated no significant change. Effective connectivity in the nonconcussed group and controls did not show significant differences.

show abstract

Section: Discussionmentioning

confidence: 99%