Evaluating Complement-Mediated Humoral Immunity to P. falciparum Blood Stages

Boyle, Michelle J.; Reiling, Linda; Beeson, JG

doi:10.1016/j.ebiom.2016.11.022

Cited by 2 publications

(1 citation statement)

References 9 publications

(14 reference statements)

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“…Antibody-mediated complement-dependent (Ab-C’) inhibition is relevant to prevent merozoite invasion of Red Blood Cells (RBCs) during blood-stage malaria infections. C1q fixation has been represented as the main mediator of Ab-C’ inhibition through binding to the Plasmodium surface proteins MSP-1 and MSP-2 [ 23 , 24 ]. However, blood infected erythrocytes are resistant to antibody-complement mediated lysis compared to the other parasitic life cycle stages.…”

Section: Parasite’s Complement Regulatory and Evasion Moleculesmentioning

confidence: 99%

The Defensive Interactions of Prominent Infectious Protozoan Parasites: The Host’s Complement System

et al. 2022

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The complement system exerts crucial functions both in innate immune responses and adaptive humoral immunity. This pivotal system plays a major role dealing with pathogen invasions including protozoan parasites. Different pathogens including parasites have developed sophisticated strategies to defend themselves against complement killing. Some of these strategies include the employment, mimicking or inhibition of host’s complement regulatory proteins, leading to complement evasion. Therefore, parasites are proven to use the manipulation of the complement system to assist them during infection and persistence. Herein, we attempt to study the interaction´s mechanisms of some prominent infectious protozoan parasites including Plasmodium, Toxoplasma, Trypanosoma, and Leishmania dealing with the complement system. Moreover, several crucial proteins that are expressed, recruited or hijacked by parasites and are involved in the modulation of the host´s complement system are selected and their role for efficient complement killing or lysis evasion is discussed. In addition, parasite’s complement regulatory proteins appear as plausible therapeutic and vaccine targets in protozoan parasitic infections. Accordingly, we also suggest some perspectives and insights useful in guiding future investigations.

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Section: Parasite’s Complement Regulatory and Evasion Moleculesmentioning

confidence: 99%

The Defensive Interactions of Prominent Infectious Protozoan Parasites: The Host’s Complement System

et al. 2022

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Complement in malaria immunity and vaccines

Kurtovic

Boyle

Opi

et al. 2019

Immunological Reviews

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Developing efficacious vaccines for human malaria caused by Plasmodium falciparum is a major global health priority, although this has proven to be immensely challenging over the decades. One major hindrance is the incomplete understanding of specific immune responses that confer protection against disease and/or infection. While antibodies to play a crucial role in malaria immunity, the functional mechanisms of these antibodies remain unclear as most research has primarily focused on the direct inhibitory or neutralizing activity of antibodies. Recently, there is a growing body of evidence that antibodies can also mediate effector functions through activating the complement system against multiple developmental stages of the parasite life cycle. These antibody‐complement interactions can have detrimental consequences to parasite function and viability, and have been significantly associated with protection against clinical malaria in naturally acquired immunity, and emerging findings suggest these mechanisms could contribute to vaccine‐induced immunity. In order to develop highly efficacious vaccines, strategies are needed that prioritize the induction of antibodies with enhanced functional activity, including the ability to activate complement. Here we review the role of complement in acquired immunity to malaria, and provide insights into how this knowledge could be used to harness complement in malaria vaccine development.

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Evaluating Complement-Mediated Humoral Immunity to P. falciparum Blood Stages

Cited by 2 publications

References 9 publications

The Defensive Interactions of Prominent Infectious Protozoan Parasites: The Host’s Complement System

The Defensive Interactions of Prominent Infectious Protozoan Parasites: The Host’s Complement System

Complement in malaria immunity and vaccines

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