Evaluating cochlear function and the effects of noise exposure in the B6.CAST+Ahl mouse with distortion product otoacoustic emissions

Comparison of distortion product otoacoustic emissions in 28 inbred strains of mice

“…Because of their unique association with OHCs, DPOAEs have been used to monitor or screen for changes to the cochlea's OHC system (e.g., Parham, 1997;Parham et al, 1999;Jimenez et al, 1999Jimenez et al, , 2001Vazquez et al, 2001Vazquez et al, , 2004Candreia et al, 2004) caused by a number of conditions including age-related hearing loss (AHL). Aside from screening for cochlear abnormalities in various strains of mice, DPOAEs have also been used to study the effects of genetic manipulations in inbred mouse stains.…”

“…For example, Liberman et al (2004) used DPOAEs to study cochlear function in prestin knock-out mice in which the motor protein responsible for the so-called 'cochlear amplifier' (Davis, 1983) was no longer expressed. Vazquez et al (2004) also used DPOAEs to compare the aftereffects of exposure to intense noises in C57BL/6J mice that exhibit AHL as compared to 'corrected' B6.CAST mice in which the ahl allele was replaced with the wild type CAST allele.…”

A Chromosome 17 Locus Engenders Frequency-Specific Non-Progressive Hearing Loss that Contributes to Age-Related Hearing Loss in Mice

“…5A). Noise exposure in young mice renders the inner ear significantly more vulnerable to aging pathology and hearing loss (Kujawa and Liberman 2006), especially in mice susceptible to AHL (Erway et al 1996;Davis et al 2001;Vázquez et al 2004;Nemoto et al 2004). As such, we wanted to examine if repeated ABR testing would have any effect on subsequent hearing threshold results.…”

“…The 129S6 inbred mouse is a unique model of presbycusis in that it has early-onset AHL starting by 1 month of age, as well as having a remarkable resistance to noise-induced hearing loss (NIHL) (Yoshida et al 2000;Rosowski et al 2003;Ohlemiller and Gagnon 2004;Street et al 2014). Other known mice with AHL have a predisposition for NIHL, suggesting these traits are associated (Erway et al 1996;Davis et al 2001;Vázquez et al 2004). Most of the work in the 129S6 strain has focused on understanding the genetic basis for noise resistance (NR).…”

Les otoémissions en pratique clinique et chirurgicale

“…Les OEA sont ainsi également très rapidement altérées lors d'un traumatisme acoustique. L'utilisation des PDA est ainsi très largement répandue dans les laboratoires de recherche [35,36]. Cette sensibilité intéresse aussi très logiquement les militaires dont la population a des raisons d'être plus fré-quemment soumise à des intensités sonores élevées [37].…”