Evaluating Binol-Aldehyde as a Chiral Derivatizing Agent for Diamines

Abstract

Abstract. We have synthesized and tested a new binolaldehyde compound 1, against five diamine compounds. Using 1 H NMR (400 MHz) spectroscopy, stable diasteriomeric imine complexes between 1 and five diamines were formed. Chemical shift nonequivalences (up to 0.058 ppm) were obtained for imines. Linear calibration plot was obtained for determining the enantiopurity of diamines.