Evaluating associations between early pregnancy trace elements mixture and 2nd trimester gestational glucose levels: A comparison of three statistical approaches

Zheng, Yinnan; Zhang, Cuilin; Weisskopf, Marc G.; Williams, Paige L.; Henn, Birgit Claus; Parsons, Patrick J.; Palmer, Christopher D.; Louis, Germaine M. Buck; James‐Todd, Tamarra

doi:10.1016/j.ijheh.2019.113446

Cited by 27 publications

(10 citation statements)

References 59 publications

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“…Data generated in this study provide a resource for the development of epigenetic biomarkers of past exposures 52 . For instance, it was generally believed that the essential element molybdenum (Mo) is safe for human health 53 ; however, there is growing evidence that excess of Mo is associated with developmental effects and with adverse health outcomes 20,[54][55][56][57][58] . In this study, maternal levels of Mo were associated with methylation changes in a remarkable number of CpGs, which were persistent at least until childhood (when we detected them).…”

Section: Discussionmentioning

confidence: 99%

Multi-omics signatures of the human early life exposome

et al. 2022

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Environmental exposures during early life play a critical role in life-course health, yet the molecular phenotypes underlying environmental effects on health are poorly understood. In the Human Early Life Exposome (HELIX) project, a multi-centre cohort of 1301 mother-child pairs, we associate individual exposomes consisting of >100 chemical, outdoor, social and lifestyle exposures assessed in pregnancy and childhood, with multi-omics profiles (methylome, transcriptome, proteins and metabolites) in childhood. We identify 1170 associations, 249 in pregnancy and 921 in childhood, which reveal potential biological responses and sources of exposure. Pregnancy exposures, including maternal smoking, cadmium and molybdenum, are predominantly associated with child DNA methylation changes. In contrast, childhood exposures are associated with features across all omics layers, most frequently the serum metabolome, revealing signatures for diet, toxic chemical compounds, essential trace elements, and weather conditions, among others. Our comprehensive and unique resource of all associations (https://helixomics.isglobal.org/) will serve to guide future investigation into the biological imprints of the early life exposome.

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Section: Discussionmentioning

confidence: 99%

Multi-omics signatures of the human early life exposome

et al. 2022

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“…It is generally believed that Mo is safe for human health (Novotny and Peterson, 2018). However, there is growing evidence that excess of Mo is associated with some adverse health outcomes in the general population (Meeker et al, 2008, 2010) and with developmental effects in utero (Gauglitz et al, 2020; Vázquez-Salas et al, 2014; Yin et al, 2020; Zheng et al, 2020). Reproductive and genotoxic effects of Mo have been reported in animals with retarded fetal growth (Mohamed et al, 2020; Tallkvist and Oskarsson, 2015).…”

Section: Resultsmentioning

confidence: 99%

Multi-omics signatures of the human early life exposome

Maitre

Hernández-Ferrer

Thiel

et al. 2021

Preprint

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Environmental exposures during early life play a critical role in life-course health, yet the molecular phenotypes underlying environmental effects on health are poorly understood. In the Human Early Life Exposome (HELIX) project, a multi-centre cohort of 1,301 mother-child pairs, we associated individual exposomes consisting of >100 chemical, physical and lifestyle exposures assessed in pregnancy and childhood, with multi-omics profiles (methylome, transcriptome, metabolome and proteins) in childhood. We identified 1,170 associations, 249 in pregnancy and 921 in childhood, which revealed potential biological responses and sources of exposure. The methylome best captures the persistent influence of pregnancy exposures, including maternal smoking; while childhood exposures were associated with features from all omics layers, revealing novel signatures for indoor air quality, essential trace elements, endocrine disruptors and weather conditions. This study provides a unique resource (https://helixomics.isglobal.org/) to guide future investigation on the biological effects of the early life exposome.

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“…Comparisons with other studies provides additional context. For example, the National Institute of Child Health and Human Development (NICHD) Fetal Growth Studies reported maternal plasma Mo concentration of 1.9 [interquartile range (IQR): 1.3] μg/L at 10–13 weeks gestation among 1,720 subjects ( 6 ). Yin et al ( 7 ) reported Mo concentrations in the serum of pregnant women recorded as 2.378 (1.757–2.938) ng/mL, 2.413 (1.835–2.970) ng/mL, 2.327 (1.727–2.930) ng/mL, and 2.816 (2.392–3.496) ng/mL in cases of total orofacial clefts, cleft lip with cleft palate, cleft lip only ( n =130), and in controls ( n =260) respectively.…”

Section: Discussionmentioning

confidence: 99%

Molybdenum Concentration and the Risk of Spontaneous Preterm Birth: A Nested Case-Control Study — Beijing Municipality, China, 2018–2020

Huang,

Zheng,

Wang

et al. 2024

China CDC Weekly

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What is already known about this topic? The level of molybdenum (Mo) in a mother’s urine has been linked to the growth rate of the fetus and the blood pressure levels in children. What is added by this report? We evaluated the variations in maternal plasma Mo concentrations throughout pregnancy and their potential association with the risk of spontaneous preterm birth (SPB). What are the implications for public health practice? Future research must determine the Mo levels in pregnant women across various regions in China. Moreover, particular attention needs to be given to the potential increase in Mo concentration throughout pregnancy and its possible adverse impacts on the health of both the mother and the fetus.

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Evaluating associations between early pregnancy trace elements mixture and 2nd trimester gestational glucose levels: A comparison of three statistical approaches

Cited by 27 publications

References 59 publications

Multi-omics signatures of the human early life exposome

Multi-omics signatures of the human early life exposome

Multi-omics signatures of the human early life exposome

Molybdenum Concentration and the Risk of Spontaneous Preterm Birth: A Nested Case-Control Study — Beijing Municipality, China, 2018–2020

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