Evaluating apoptotic gene efficiency for CHO culture performance using targeted integration
David Catalán-Tatjer,
Saravana Kumar Ganesan,
Iván Martínez-Monge
et al.
Abstract:Chinese hamster ovary (CHO) cells have long been the favoured platform for producing complex biopharmaceuticals such as monoclonal antibodies (mAbs). Cell death is a critical factor in all CHO cultures, dictating duration until harvest in batch cultures and viable cell density in perfusion. The programmed cell death, or apoptosis, pathway has been widely studied due to its relevance in affecting cell culture performance and the extensive knowledge about its protein-to-protein interaction network. However, clon… Show more
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