Evaluating "anxiety" and social behavior in jundiá (Rhamdia quelen)

Abreu, Murilo S. de; Giacomini, Ana C.V.V.; Koakoski, Gessi; Piato, Ângelo; Barcellos, Leonardo José Gil

doi:10.1016/j.physbeh.2016.04.003

Cited by 15 publications

(9 citation statements)

References 40 publications

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“…Fighting is stressful for fish (Øverli et al 1999, 2004), and even after 12 h of FLX treatment, matrinxãs were able to properly respond to this stressor, reaching cortisol levels that were similar to the control group and consistent with cortisol levels observed in matrinxã (control fish) after a similar fight paradigm demonstrated in previous studies (Wolkers et al 2014;Serra et al 2016). In jundiá Rhamdia quelen juveniles, a short (17 min) exposure to FLX in the water also altered the behavior (had an anxiolytic effect) without impairing the stress response (Abreu et al 2016). Our study also demonstrated that cortisol levels were unaffected by the treatment with FLX, with both groups presenting similar hormonal levels to those described in a previous study that used FLX intraperitoneal implants for an acute treatment (McDonald et al 2011).…”

Section: Discussionsupporting

confidence: 86%

“…Another hypothesis for the increased aggressiveness observed is the influence of FLX on anxiety and boldness. FLX is a drug with anxiolytic effects that have been reported in fish (Lynn et al 2007;Maximino et al 2011;Barbosa Júnior et al 2012;Abreu et al 2016), and lines selected for low anxiety-related behavior are more aggressive than lines with high anxiety-related behavior or nonselected mice (Neumann et al 2010). Furthermore, FLX treatment can also improve the boldness in fish (Winberg and Thörnqvist 2016), and this effect can be related to increased aggressiveness, as proactive animals tend to be more bold and aggressive (Benus et al 1991).…”

Section: Discussionmentioning

confidence: 99%

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Acute fluoxetine treatment increases aggressiveness in juvenile matrinxã (Brycon amazonicus)

Wolkers

Serra

Júnior

et al. 2016

Fish Physiol Biochem

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Fluoxetine (FLX) is a selective serotonin (5-HT) reuptake inhibitor known for its effects modifying aggressiveness, personality traits, and anxiety-like behaviors. The aim of the present study was to evaluate the influence of the acute treatment, by immersion, with FLX on aggressive behavior of resident Brycon amazonicus fish. Fish pretreated with FLX presented an increase in aggressiveness, evidenced by the increase on the number of bites and chases against the intruder and a decrease in latency for the first attack, when compared to control fish. Together with previous studies, these results show the complexity of the neural modulation of the aggressive behavior in fish by 5-HTergic system.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Acute fluoxetine treatment increases aggressiveness in juvenile matrinxã (Brycon amazonicus)

Wolkers

Serra

Júnior

et al. 2016

Fish Physiol Biochem

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“…According to Barcellos et al [75] and Abreu et al [76], it is possible to assess the anxiety using latency as a parameter, since higher latency to enter the superior part of the tank indicates higher anxiety and higher depression. Regarding this parameter, the group treated with 1% ethanol had higher latency to explore the top, followed by the groups of chronic stress and social isolation.…”

Section: Discussionmentioning

confidence: 99%

Anxiolytic and Antidepressant Effects of the Hydroethanolic Extract from the Leaves of Aloysia polystachya (Griseb.) Moldenke: A Study on Zebrafish (Danio rerio)

et al. 2019

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Medicinal plants such as Aloysia polystachya are often used in the treatment of psychiatric diseases, including anxiety- and depression-related humor disturbances. In folk medicine, A. polystachya is used to treat digestive and respiratory tract disturbances, as a sedative and antidepressant agent, and as a tonic for the nerves. This study aimed to evaluate the antidepressant and anxiolytic effect from the hydroethanolic extract from the leaves of Aloysia polystachya (HELAp) in zebrafish. The extract was analyzed through ultra-performance liquid chromatography-mass spectroscopy (UPLC-MS) and the main compound detected was acteoside. HELAp was administered orally (10 mg/kg) and through immersion (mg/L). The anxiolytic activity was evaluated through the scototaxis (light–dark) test using caffeine as an anxiogenic agent and buspirone as a positive control. The parameters assessed were: period spent in the white compartment (s), latency (s), alternations (n), erratic swims (n), period of freezing (s), thigmotaxis (s), and risk evaluation (n). The antidepressant effect was evaluated through the novel tank diving test using 1% ethanol, unpredictable chronic stress, and social isolation as depressors; fluoxetine was used as a positive control. The parameters assessed were: period spent at the top of the tank, latency, quadrants crossed, erratic swim, period of freezing, and distance of swam. The main chemical compound of HELAp was acteoside. The administration of the extract on zebrafish managed to revert the anxiogenic effect of caffeine without impairing their locomotion. Additionally, the treatment exerted antidepressant activity similarly to fluoxetine. Overall, the results suggest a significant anxiolytic and antidepressant activity to the extract, which is probably due to the presence of the major compound, acteoside.

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“…After 28 d of exposure, six fish from each group were randomly selected to perform the anxiety and behavioral analysis, according to a previous report [ 31 ]. Firstly, the fish were acclimatized to the environment for 30 min in a round tank, and then the fish movement trajectories and movement parameters, including movement distance, average speed, max speed, absolute turn angle, mean distance to border, and max distance to border were recorded using a HD98 camera (Hunan Huafu Technology Co., Ltd., Changde, China) for further analysis using the ANY-MAZE software (version 4.3, Stoelting, Wood Dale, IL, USA).…”

Section: Methodsmentioning

confidence: 99%

Neurotoxicity of Chronic Co-Exposure of Lead and Ionic Liquid in Common Carp: Synergistic or Antagonistic?

Ding

Sultan

et al. 2022

IJMS

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Previous studies have indicated that the harmful heavy metal lead (Pb) contamination in aquatic systems has caused intelligence development disorders and nervous system function abnormalities in juveniles due to the increased permeability of the blood–brain barrier. Ionic liquids (ILs) are considered “green” organic solvents that can replace traditional organic solvents. Studies have found the presence of ILs in soil and water due to chemical applications or unintentional leakage. Therefore, what would happen if Pb interacted with ILs in a body of water? Could ILs enable Pb to more easily cross the blood–brain barrier? Therefore, we examined the combined exposure of Pb and ILs in common carp at low concentration (18.3 mg L−1 of Pb(CH3COO)2•3 H2O and 11 mg L−1 of the IL 1-methyl-3-octylimidazolium chloride, 5% of their LC50) for 28 days in the present study. The result of a neurobehavioral assay showed that chronic exposure of lead at lower concentrations significantly altered fish movement and neurobehaviors, indicating that lead exposure caused neurotoxicity in the carp. Increases in the neurotransmitter dopamine levels and injuries in the fish brain accounted for neurobehavioral abnormalities induced by lead exposure. Moreover, we also found that lead could easily cross the blood–brain barrier and caused significant bioaccumulation in the brain. Particularly, our study indicated that the ionic liquid could not synergistically promote blood–brain barrier permeability and hence failed to increase the absorption of lead in the fish brain, suggesting that the combined exposure of lead and ILs was not a synergistic effect but antagonism to the neurotoxicity. The results of this study suggested that ILs could recede the Pb induced neurotoxicity in fish.

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Evaluating "anxiety" and social behavior in jundiá (Rhamdia quelen)

Cited by 15 publications

References 40 publications

Acute fluoxetine treatment increases aggressiveness in juvenile matrinxã (Brycon amazonicus)

Acute fluoxetine treatment increases aggressiveness in juvenile matrinxã (Brycon amazonicus)

Anxiolytic and Antidepressant Effects of the Hydroethanolic Extract from the Leaves of Aloysia polystachya (Griseb.) Moldenke: A Study on Zebrafish (Danio rerio)

Neurotoxicity of Chronic Co-Exposure of Lead and Ionic Liquid in Common Carp: Synergistic or Antagonistic?

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