“…YM is increasingly being used to manage symptoms and risk factors associated with many chronic diseases, 17,18 such as cancer, 19,20 diabetes, 21 hypertension, 22 cardiovascular disease, 23 and AIDS. [24][25][26][27][28] Studies in PLWH showed that YM decreased pain and anxiety, 1,29 increased CD4 T lymphocytes independently of ART, 30 increased CD2 + counts, 31 improved overall survival rates, 32 and increased motivation for drug abstinence and HIV prevention behaviors. 33 A large body of evidence suggests that HIV and ART, along with drug abuse, lead to a wide spectrum of abnormalities in immunologic, neurologic, and neuroendocrine systems, even during the asymptomatic phase of infection.…”