Evaluating a simple blending approach to prepare magnetic and stimuli-responsive composite hydrogel particles for application in biomedical field

Abstract

Abstract. The inclusion of super paramagnetic iron oxide (Fe 3 O 4 ) nanoparticles in stimuli-responsive hydrogel is expected to enhance the application potential for cellular therapy in cell labeling, separation and purification, protein immobilization, contrasting enhancement in magnetic resonance imaging (MRI), localized therapeutic hyperthermia, biosensors etc. in biomedical field. In this investigation two different magnetic and stimuli-responsive composite hydrogel particles with variable surface property were prepared by simply blending Fe 3 O 4 /SiO 2 nanocomposite particles with stimuli-responsive hydrogel particles. Of the hydrogel particles prepared by free-radical precipitation polymerization poly(styrene-N-isopropylacrylamide-methyl methacrylate-polyethylene glycol methacrylate) or P(S-NIPAM-MMA-PEGMA) was temperature-sensitive and poly(S-NIPAM-methacrylic acid-PEGMA) or P(S-NIPAM-MAA-PEGMA) was both temperature-and pH-responsive. The morphological structure, size distributions and volume phase transitions of magnetic and stimuli-responsive composite hydrogel particles were analyzed. Temperature-responsive absorptions of biomolecules were observed on both magnetic and stimuli-responsive Fe 3 O 4 /SiO 2 /P(S-NIPAM-MMA-PEGMA) and Fe 3 O 4 /SiO 2 /P(S-NIPAM-MAA-PEGMA) composite hydrogel particles and separation of particles from the dispersion media could be achieved by applying magnetic field without time consuming centrifugation or decantation method.

Polymer/boehmite nanocomposites: A review

“…This low‐cost membrane, composed of sulfosuccinic acid‐crosslinked PVA, exhibited good proton conductivity and low hydrogen permeability . Modification of hydrogels, especially the “smart” and superabsorbent versions may be an emerging research topic, as well.…”

Rational design of stimuli‐responsive magnetic polymer hybrid (nano)materials

“…Among the reported synthetic strategies, a common strategy relies on the reaction between MNPs functionalized with reactive amine groups and stimuli-responsive polymers presenting carboxylic acid groups. [66][67][68][69] For example, Sahoo et al 67 reported the reaction of PNI-PAM-b-PAA block copolymer with 3-(aminopropyl)triethoxysilane (APTES)-modified magnetite IONPs, providing MNP@PAA-b-PNIPAM hybrids through amide bond formation. The usual characterization techniques (XRD, FTIR, HR-TEM) confirmed the crystalline structure of magnetite and the formation of core-shell hybrids.…”

Smart polymer nanocomposites: A review

“…It is found that the MTN can de-swell more than 80% of its initial weight within a short time (approximately 6 minutes) under an alternating magnetic field. Ahmad et al [104] A smart liquid microvalve made by the nanocomposite hydrogel has been fabricated, and it could be remotely controlled by NIR switch effectively.…”

“…Bar diagram represents the amount of absorptions of trypsin on (a) Fe 3 O 4 /SiO 2 nanocomposite, (b) Fe 3 O 4 /SiO 2 /P(S-NIPAm-MAA-PEGMA) and (c) Fe 3 O 4 /SiO 2 /P(S-NIPAm-MMA-PEGMA) composite hydrogel particles at temperature above (40°C) and below (20°C) of the LCST. Absorption: immobilization 200 mg/g of particles, pH 10.0, immobilization time 45 min (reproduced from Ahmad et al[104]). …”