Evaluate the diagnosis of neonatal sepsis by measuring interleukins: A systematic review

Boskabadi, Hassan; Zakerihamidi, Maryam

doi:10.1016/j.pedneo.2017.10.004

Cited by 16 publications

(21 citation statements)

References 30 publications

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“…In one study, positive result for CSF culture was reported in 36.88% (7). In another study, the prevalence of neonatal meningitis was 1% (22).…”

Section: Discussionmentioning

confidence: 94%

“…In one study, K. pneumoniae, Coagulase negative staphylococci, and Enterococcus faecalis were the most common bacterial pathogens (28). In the study of Samiee Rad et al (2012), the most common pathogens were E. coli, K. pneumoniae, Enterobacter, Pseudomonas aeruginosa and Staphylococcus aureus (22). Several mechanisms have been described for neonatal meningitis, but primary septicemia and then the secondary distribution in cerebrospinal fluid is the most common underlying issue (38).…”

Section: Discussionmentioning

confidence: 99%

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Etiology, clinical findings and laboratory parameters in neonates with acute bacterial meningitis

Boskabadi¹,

Heidari²,

Zakerihamidi³

2020

IJM

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Background and Objectives: Neonatal meningitis is one of the most important and serious neonatal infections with a high mortality and morbidity rate. The present study aimed to investigate the causes, clinical signs, laboratory parameters and mortality rates in newborns with bacterial meningitis. Materials and Methods: This cross-sectional study was performed on 468 neonates aged 2-28 days admitted to NICU in Ghaem Hospital Mashhad, Iran by available sampling method during 2009-2018. Meningitis was confirmed according to positive results of CSF culture and clinical feature. By using researcher-made questionnaire, neonate's individual data in- cluding cardiopulmonary resuscitation, the Apgar score of the first and fifth minutes, gestational age, birth weight, clinical symptoms and laboratory data such as ESR, WBC and positive culture of CSF were studied. Results: Among 468 newborn suspected to infection, lumbar Puncture (LP) was performed for 233 cases (50%). Of 233 neonates, 148 neonates (63.5%) had negative results for CSF culture and 85 cases (36.5%) had positive CSF culture. 94% of cases with meningitis were born premature. Blood culture had positive results in 80% of infants with late-onset meningitis and negative in 20%. The most common clinical findings were respiratory symptoms (94%). Klebsiella pneumoniae and Entrobacter aerugenes were the most common microorganisms of meningitis. Gestational disorders were observed in 55.3% of newborns with meningitis. C-Reactive Protein (CRP) of neonates with meningitis was twice higher than normal cases, and leukocytes and proteins in the CSF in neonates with meningitis were higher than healthy ones. Finally, 36% of neonates with meningitis died in our study. For analyzing the relationships between variables, independent t-test was used after controlling the normality, and Chi-square was used for analyzing the relationship of variables with nominal scale. Conclusion: The most common pathogens of meningitis were Klebsiella pneumoniae and Enterobacter aerogenes. Respi- ratory symptoms were the most common clinical signs, and laboratory symptoms included increased CRP, increased leuko- cytes and proteins in CSF

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“…In one study, positive result for CSF culture was reported in 36.88% (7). In another study, the prevalence of neonatal meningitis was 1% (22).…”

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Etiology, clinical findings and laboratory parameters in neonates with acute bacterial meningitis

Boskabadi¹,

Heidari²,

Zakerihamidi³

2020

IJM

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“…For this reason, it could be possible to be related to a gene for sepsis [11]. A systemic fetal cytokine response, defined as a plasma interleukin-6 (IL-6) value above 11 pg/m is considered a major independent risk factor, such as fetal inflammatory response syndrome (FIRS), a diagnostic marker of early-onset neonatal sepsis (EONS) and a risk predictor of white matter injury (WMI) [12].…”

Section: Universidad De Manizales -Facultad De Ciencias De La Saludmentioning

confidence: 99%

“…On the other hand, concentrations of IL-6 have also been determined [20] during the microbial invasion of the amniotic cavity (MIAC) and amniotic fluid after delivery, and they evaluated the presence of acute histological chorioamnionitis (ACH) in the placenta. They also observed a greater intra-amniotic inflammatory response, which was mediated by IL-6 concentrations.…”

Section: Distribution Of Newborn Sex Risk Factors Sepsis and Intermentioning

confidence: 99%

Maternal risk factors in full-term newborns with early onset sepsis related with Interleukin-6 in umbilical blood

González-Andrade¹

2019

archmed

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Background: to determine the relationship and association of early sepsis with interleukin-6 measured in umbilical blood, as well as gestational age and birth weight, prenatal history of the mother pathologies during pregnancy, in full-term newborns at the Neonatology Service of Carlos Andrade Marín Hospital (Quito). Subjects and methods: epidemiological, observational, analytical, cross-sectional. 200 newborns were analyzed. IL-6 was determined by Elisa. Results: newborn mean gestational age 38.4±2 weeks, mean weight 2871±532.4 grams, cutoff point interleukin 6 ≤14pg/uL; mean of IL6. 58±99,1 pg/uL; male sex was 43.9%, female sex 56.1%; preeclampsia of the mother 22.4%, prenatal infection of the urinary tract 20.4%; vaginitis/vaginosis 19.4%; IL6 values ≤ 14 pg/uL in 63.3% of patients; IL6 values of >14 pg/uL 36.7%; relationship with sepsis in all, p<0.05; relationship of prenatal pre-maternity of the mother and neonatal sepsis. p<0.05; relationship between vaginitis/vaginosis of the mother with neonatal sepsis; p<0.05; OR: 38.88 IC95% (4.912-307.728); association between sepsis and risk factors, IL6, gestational age in weeks, weight, prenatal preeclampsia, prenatal urinary tract infection, vaginitis/vaginosis, p<0.05. Conclusion: It is concluded that there is a relationship of risk factors, such as, gestational age in weeks, weight, prenatal preeclampsia, prenatal UTI, vaginitis/vaginosis and values of interleukin 6 ≤ 14 pg/uL. The mean gestational age was 38.4 weeks, and average weight 2871 grams in the newborns analyzed.

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“…Bacterial culture is considered the gold standard for the diagnosis of NS, but it takes 1 to 2 days to obtain the examination results with low sensitivity (4). In addition, several biological markers with high sensitivity have been identified, including interleukins (ILs), C-reactive protein (CRP), micro-erythrocyte sedimentation rate and procalcitonin (PCT) (5)(6)(7). However, the clinical application of these indicators is limited due to their poor specificity.…”

Section: Introductionmentioning

confidence: 99%

Clinical significance of miR‑181a in patients with neonatal sepsis and its regulatory role in the lipopolysaccharide‑induced inflammatory response

Guo

2020

Exp Ther Med

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Neonatal sepsis (NS) poses a serious threat to the health of neonates worldwide. The present study aimed to investigate the diagnostic value of microRNA (miR)-181a in patients with NS and the regulatory role of miR-181a in lipopolysaccharide (LPS)-induced inflammation. A total of 102 neonates with NS and 50 neonates without sepsis were enrolled in the present study. The serum levels of miR-181a were estimated using reverse transcription-quantitative PCR. Receiver operating characteristic (ROC) analysis was performed to evaluate the diagnostic value of miR-181a for NS. The effect of miR-181a on the expression of Toll-like receptor (TLR)4 was assessed after modification of the expression of miR-181a in monocytes isolated from the blood of neonates in vitro. An ELISA was used to measure the concentration of inflammatory cytokines tumor necrosis factor (TNF)-α and interleukin (IL)-8 in the supernatant of monocytes. The serum levels of miR-181a were decreased in patients with NS compared with those in the controls. The area under the ROC curve of miR-181a was 0.893 with a sensitivity of 83.3% and a specificity of 84.0%. LPS stimulation in monocytes also led to a decrease in the expression of miR-181a. TLR4 was proven to be a direct target gene of miR-181a, according to the results of a luciferase reporter assay, and overexpression of miR-181a suppressed TLR4 expression in monocytes. Regarding LPS-induced inflammation, it was revealed that the upregulated levels of TNF-α and IL-8 induced by LPS were reduced by overexpression of miR-181a in monocytes. In conclusion, decreased serum levels of miR-181a may serve as a diagnostic biomarker in patients with NS and overexpression of miR-181a inhibits the LPS-induced inflammatory response at least partially by targeting TLR4. Aberrant miR-181a may be a non-invasive biomarker for NS patients, and provide a novel insight into the pathologic mechanisms of action behind the development of NS.

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Evaluate the diagnosis of neonatal sepsis by measuring interleukins: A systematic review

Cited by 16 publications

References 30 publications

Etiology, clinical findings and laboratory parameters in neonates with acute bacterial meningitis

Etiology, clinical findings and laboratory parameters in neonates with acute bacterial meningitis

Maternal risk factors in full-term newborns with early onset sepsis related with Interleukin-6 in umbilical blood

Clinical significance of miR‑181a in patients with neonatal sepsis and its regulatory role in the lipopolysaccharide‑induced inflammatory response

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