Evaluat I on of Various Prognostic Factors in Perforative Peritonitis Management

Abstract

Peritonitis is one of the major problems confronting the surgeons in day to day practice. Despite many advances in understanding pathophysiology, mortality rate of diffuse suppurative peritonitis remains high. A prospective study, with prior institutional ethics committee approval, involving 100 patients of perforative peritonitis is done to assess the various prognostic factors in management of generalized peritonitis. Role of age, gender, duration, type of perforation, associated systemic factors are studied in relation to morbidity and mortality in the outcome of management of peritonitis. Elderly age, ileal perforations, delay in presentation of more than 24 hours and associated shock on day one are found to have bad prognosis.

"Peritonitis: Relevance and Choice of Adequate Experimental Model"

“…It has also been established that the risk of death in patients with severe DP increases in case of delayed surgical treatment (later than 6 hours from the patient hospitalization) or antimicrobial therapy (later than 1 hour from the admission to the surgical department) and depends on the presence of multiple organ failure in the patient [6]. It is the multiple organ failure, along with septic shock, that are the most common causes in this pathology by 70% or more [7][8][9][10]. In addition, it is known that DP is one of eight risk factors in calculation of the Mannheim peritonitis index, which makes it possible to determine the severity of the pathology and, to a certain extent, predict lethality in a particular patient [11].…”

"Some Indicators of Intoxication and Leukocyte Response in Rodent Fecal Peritonitis"

“…Diffuse peritonitis remains one of the urgent problems of surgery due to the persistent high mortality rate of 27,8-53,4 %, which reaches 85-90% with the development of septic shock and multiple organ failure [1][2][3]. At the same time, the most numerous group of patients with peritonitis is a working age group [4], and its treatment requires significant economic expenses, which are much more higher than the expenses for treatment of diseases not accompanied by infectious complications [5].…”

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“…Diffuse peritonitis remains one of the urgent problems of surgery due to the persistent high mortality rate, which reaches 85-90% with the development of septic shock and multiple organ failure [1][2][3]. At the same time, the most numerous group of patients with peritonitis is a working age group [4], and its treatment requires significant economic expenses, which are much more higher than the expenses for treatment of diseases not accompanied by infectious complications [5].…”