Evaluasi Stabilitas Fisik Dan Profil Difusi Sediaan Gel (Minyak Zaitun)

Mursyid, A. Mumtihanah

doi:10.33096/jffi.v4i1.229

Cited by 11 publications

(11 citation statements)

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“…The gel which is stored at cold temperatures, shortens and joins the polymer chains together. Also, it shrivels (entangle), due to changes in viscosity after conditions [32]. TEA as an alkaline agent serves to prevent carbopol, which is easily broken down by heat, thereby causing a decrease in gel viscosity.…”

Section: Stability Test Of Nanosilver Biosynthetic Hydrogelmentioning

confidence: 99%

Stability and Antibacterial Activity Test of Nanosilver Biosynthetic Hydrogel

et al. 2022

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Objective: This study aims to formulate nanosliver (AgNPs) biosynthetic hydrogel for topical antibacterial treatment and its stability and antibacterial activity. Methods: The mixture (Silver nitrate solution and Turmeric juice) was stirred at room temperature for 24 h; afterward, it was analyzed using UV-VIS spectrophotometry, particle size analysis, and TEM. The carbopol 940 was selected as a gelling agent with an AgNPs concentration of 5%, 10%, 20%, and 30%. Furthermore, the gel preparation was tested for stability using the cycling test method and antibacterial activity. The antibacterial activity against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, and Pseudomonas aeruginosa. Results: The nanosilver biosynthetic has a yellow-brown color with the maximum wavelength peak at 433 nm, and a particle size of 157.4-166.7 nm. TEM analysis showed that AgNPs have a round shape, while the antibacterial activity of hydrogel preparations was moderately inhibited. Furthermore, the hydrogel was evaluated for pH, viscosity, dispersibility, and antibacterial activity before-after the cycling test. Formula with 30% AgNPs is chosen formula with pH value of 5.87±0.65; viscosity of 4833.3±2.82 c. Ps; and dispersibility of 5.50±0.15 after cycling test. Conclusion: The high concentration of AgNPs will increase the viscosity, pH, and dispersibility. Formula with 30% AgNPs have the highest antibacterial activity. Furthermore, all hydrogel preparations meet the requirements of Indonesian Standard Product (SNI) No. 06-2588-1992 for good gel stability before and after the cycling test.

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Section: Stability Test Of Nanosilver Biosynthetic Hydrogelmentioning

confidence: 99%

Stability and Antibacterial Activity Test of Nanosilver Biosynthetic Hydrogel

et al. 2022

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“…Uji homogenitas dilakukan dengan melihat sediaan di bawah lampu kemudian dilihat homogen atau tidak serta ada tidaknya partikel yang belum tercampur [6]. Uji dilakukan replikasi sebanyak tiga kali.…”

Section: Uji Sifat Fisik Sprayunclassified

Formulasi dan Uji Sifat Fisik Spray Anti Bau Kaki Minyak Atsiri Jeruk Lemon (Citrus limon Burm. F.)

Hidayati

Kurniasari

Septyasari

2021

UJMR

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Jeruk lemon (Citrus limon Burm. F.) memiliki kandungan minyak atsiri berupa limonen yang memiliki aktivitas antibakteri terhadap Staphylococcus epidermidis penyebab bau kaki. Untuk memudahkan pengaplikasiannya maka dibuat dalam bentuk spray, karena spray memiliki profil yang cepat kering sehingga mudah untuk dipakai. Penelitian ini bertujuan untuk mengetahui pengaruh variasi konsentrasi minyak atsiri jeruk lemon terhadap sifat fisik spray anti bau kaki serta untuk mengetahui konsentrasi minyak atsiri jeruk lemon yang menghasilkan spray anti bau kaki dengan sifat fisik yang baik. Spray dibuat dengan variasi konsentrasi minyak atsiri 5%, 10%, dan 15%. Spray kemudian diuji sifat fisiknya meliputi uji organoleptik, homogenitas, pH, dan viskositas. Hasil uji organoleptik dan uji homogenitas dianalisis secara deskriptif, sedangkan hasil uji pH dan uji viskositas dianalisis dengan ANOVA satu jalan. Hasil penelitian menunjukkan peningkatan konsentrasi minyak atsiri jeruk lemon mempengaruhi organoleptis dan meningkatkan nilai viskositas. Spray konsentrasi 5% menghasilkan sifat fisik yang paling baik dengan bentuk cair, warna putih keruh, beraroma khas lemon, homogen dengan nilai pH 6 ± 0, dan nilai viskositas 0,53 ± 0,06 dPas

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“…Dimana ketika suatu gel disimpan pada suhu panas rantai polimer akan melepaskan ikatan polimer sehingga viskositas gel menurun. Sedangkan pada suhu dingin rantai polimer akan memendek dan rantai akan saling bergabung menyebabkan gel lama kelamaan mengerut sehingga terjadi perubahan viskositas [19].…”

Section: Cycling Test Viskositasunclassified

Karakterisasi Dan Optimasi Formula Sediaan Gel Ekstrak Etanol Kulit Buah Pisang Kapas (Musa paradisiaca Linn.)

et al. 2021

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Cotton banana peel (Musa paradisiaca Linn.) has not been used by the community. Nanoparticles are solid colloidal particles with a diameter of 10-1000 nm. This study aims to make ethanol extract of cotton banana peel (Musa paradisiaca Linn.) as an active substance in the form of nanoparticles formulated in gel preparations and to determine the evaluation of cotton banana peel (Musa paradisiaca Linn.) nanoparticle gel. The method of making nanoparticles of ethanolic extract of cotton banana peel (Musa paradisiaca Linn.) in this research is ionic gelation. Nanoparticles of ethanolic extract of cotton banana peel (Musa paradisiaca Linn.) were characterized using particle size analyzer. Evaluation of gel preparations included organoleptic tests, homogeneity, pH, dispersibility, adhesion, viscosity and cycling tests. The cycling test includes organoleptic, pH and viscosity testing. Cycling test observations were carried out for 6 cycles. Characterization of nanoparticles of ethanolic extract of cotton banana peel (Musa paradisiaca Linn.) had a particle size of 220.3 nm with a polydipsia index of 0.139. Evaluation of pH preparations has a pH of 6, viscosity ranges from 7116 cps – 8095 cps, dispersion ranges from 5.1 cm to 5.4 cm, adhesion ranges from 1.11 seconds to 7.54 seconds. The results of the cycling test showed a change in the color of the preparation, while the cycling test for pH and viscosity did not change the stability. Conclusion The cotton banana peel extract (Musa paradisiaca Linn.) can be made into smaller particles or nanoparticles using the ionic gelation method and the evaluation of the nanoparticle gel preparation of the cotton banana peel (Musa paradisiaca Linn.) extract has met the requirements.Keywords: Cotton banana peel, gel, nanoparticles, evaluation AbstrakKulit buah pisang kapas (Musa paradisiaca Linn.) belum dimanfaatkan oleh masyarakat. Nanopartikel merupakan partikel koloid padatan dengan diameter 10-1000 nm. Penelitian ini bertujuan untuk membuat ekstrak etanol kulit buah pisang kapas (Musa paradisiaca Linn.) sebagai zat aktif dalam bentuk nanopartikel yang diformulasi dalam sediaan gel dan untuk mengetahui evaluasi gel nanopartikel kulit buah pisang kapas (Musa paradisiaca Linn.). Metode pembuatan nanopartikel ekstrak etanol kulit buah pisang kapas (Musa paradisiaca Linn.) pada penelitian ini yaitu gelasi ionik. Nanopartikel ekstrak etanol kulit buah pisang kapas (Musa paradisiaca Linn.) dikarakterisasi menggunakan particle size analyzer. Evaluasi sediaan gel meliputi uji organoleptis, homogenitas, pH, daya sebar, daya lekat, viskositas dan cycling test. Pengujian cycling test meliputi pengujian organoleptis, pH dan viskositas. Pengamatan cycling test dilakukan selama 6 siklus.Karakterisasi nanopartikel ekstrak etanol kulit buah pisang kapas (Musa paradisiaca Linn.) memiliki ukuran partikel 220,3 nm dengan indeks polidipersitas 0,139. Evaluasi sediaan pH memiliki pH 6, viskositas rentang 7116 cps – 8095 cps, daya sebar rentang 5,1 cm -5,4 cm, daya lekat rentang 1,11 detik – 7,54 detik. Hasil pengujian cycling test terdapat perubahan warna dari sediaan, sedangkan pengujian cycling test terhadap pH dan viskositas tidak mengalami perubahan stabilitas. Kesimpulan ekstrak kulit buah pisang kapas (Musa paradisiaca Linn.) dapat dibuat dalam partikel yang lebih kecil atau nanopartikel dengan menggunkan metode gelasi ionik dan evaluasi sediaan gel nanopartikel ekstrak etanil kulit buah pisang kapas (Musa paradisiaca Linn.) telah memenuhi persyaratan.Kata kunci: Kulit buah pisang kapas, gel, nanopartikel, evaluasi

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Evaluasi Stabilitas Fisik Dan Profil Difusi Sediaan Gel (Minyak Zaitun)

Cited by 11 publications

References 0 publications

Stability and Antibacterial Activity Test of Nanosilver Biosynthetic Hydrogel

Stability and Antibacterial Activity Test of Nanosilver Biosynthetic Hydrogel

Formulasi dan Uji Sifat Fisik Spray Anti Bau Kaki Minyak Atsiri Jeruk Lemon (Citrus limon Burm. F.)

Karakterisasi Dan Optimasi Formula Sediaan Gel Ekstrak Etanol Kulit Buah Pisang Kapas (Musa paradisiaca Linn.)

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