This chapter aims to elaborate a critical assessment of socio-intercultural entrepreneurship. The study is supported on the assumption that culture and social entrepreneurship are limited and that a framework analysis that helps to improve the understanding of the socio-economic realities is necessary. The research methodology employed were the exploratory and analytical instruments based on literature review and the transference of findings to a specific case on a postgraduate program in economy and international business at the Autonomous Indigenous University of Mexico. It's concluded that socio-intercultural entrepreneurship presents a methodological frame that allows entrepreneurs to have a major perception of global and local realities.