Evaluación de la función renal en la insuficiencia cardiaca

Calvo, Juan; Laorden, C. Josa; López, Iván

doi:10.1016/j.rce.2017.01.006

Cited by 4 publications

(1 citation statement)

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“…HF may lead to renal dysfunction and cardiorenal syndrome through low cardiac output, accelerated atherosclerosis, inflammation, and increased venous pressure [9]. Renal function offers valuable information for the prognostic classification of patients with stable or decompensated HF [10]. HF patients with renal impairment represent a high-risk group with an approximately 50% greater risk of mortality than those with normal renal function [11].…”

Section: Introductionmentioning

confidence: 99%

Cystatin C for predicting all-cause mortality and rehospitalization in patients with heart failure: a meta-analysis

Chen¹,

Yang-zhang

Zhou³

2019

Bioscience Reports

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Circulating cystatin C (cys-C/CYC) has been identified as an independent predictor of all-cause mortality in patients with coronary artery disease and the general population. This meta-analysis aimed to systematically evaluate the association between elevated cys-C level and all-cause mortality and rehospitalization risk amongst patients with heart failure (HF). PubMed and Embase databases were searched until December 2017. All prospective observational studies that reported a multivariate-adjusted risk estimate of all-cause mortality and/or rehospitalization for the highest compared with lowest cys-C level in HF patients were included. Ten prospective studies involving 3155 HF patients were included. Meta-analysis indicated that the highest compared with lowest cys-C level was associated with an increased risk of all-cause mortality (hazard ratio (HR): 2.33; 95% confidence intervals (CI): 1.67–3.27; I2 = 75.0%, P<0.001) and combination of mortality/rehospitalization (HR: 2.06; 95%CI: 1.58–2.69; I2 = 41.6%, P=0.181). Results of stratified analysis indicated that the all-cause mortality risk was consistently found in the follow-up duration, cys-C cut-off value or type of HF subgroup. Elevated cys-C level is possibly associated with an increased risk of all-cause mortality and rehospitalization in HF patients. This increased risk is probably independent of creatinine or estimated glomerular filtration rate (eGFR).

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Section: Introductionmentioning

confidence: 99%