Evaluación de la efectividad del colirio de suero autólogo en el tratamiento de patologías oculares

Botella, Alejandro Jover; Peiró, Juan Francisco Márquez; Marques, Karina Kendra Mar; Cambero, N. Monts; Otaolaurruchi, Juan Selva

doi:10.1016/j.farma.2010.02.004

Cited by 9 publications

(3 citation statements)

References 10 publications

(8 reference statements)

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“…Nonetheless, dilution may reduce the concentration of other beneficial factors at the same time, particularly EGF and fibronectin, which are proven to support proliferation and migration of corneal epithelial cells [14]. Although most published studies have reported the use of 20% autologous serum eye drops for treating a number of ocular surface conditions, some demonstrated good results in terms of both efficacy and safety at higher concentrations of 50–100% as well [6, 15–17]. The undiluted autologous serum has previously been shown to be more effective than 20% serum in the epithelial healing process of mechanical corneal ulcers in animal study [18].…”

Section: Introductionmentioning

confidence: 99%

Topical 100% Serum Eye Drops for Treating Corneal Epithelial Defect after Ocular Surgery

Lekhanont

Jongkhajornpong

Choubtum

et al. 2013

BioMed Research International

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The purpose of this study was to investigate the efficacy and safety of topical 100% serum eye drops for corneal epithelial defect after ocular surgery. A total of 181 patients who received topical 100% serum therapy for the treatment of corneal epithelial defect following several different types of ocular surgery were recruited into this study. Each patient already failed conventional medical therapy before being prescribed 100% serum eye drops. Slit-lamp biomicroscopic examination with fluorescein staining was performed at baseline and all follow-up visits. The main outcome measures were the rate of complete healing of the corneal epithelial defect and incidence of adverse events. One hundred and seventy-eight eyes (98.34%) received autologous serum eye drops, and 3 (1.66%) received allogeneic serum eye drops. The overall success rate of treating persistent postoperative epithelial defect using 100% serum eye drops was 93.92% (95% CI 0.88–0.98). The median time to complete corneal epithelialization was 4 days (95% CI 4-5). Adverse reactions were observed in 3 patients (1.66%), including sticky sensation with minimal eye discomfort and asymptomatic trace corneal subepithelial infiltration. No serious complications were reported. In conclusion, 100% serum eye drops are effective, safe, and tolerable for treating postoperative corneal epithelial defect following ocular surgeries.

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Section: Introductionmentioning

confidence: 99%

Topical 100% Serum Eye Drops for Treating Corneal Epithelial Defect after Ocular Surgery

Lekhanont

Jongkhajornpong

Choubtum

et al. 2013

BioMed Research International

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“…Most of the recent analyzed trials have tested the clinical results coming from SE treatment through the comparison with traditional therapeutic approaches such as artificial tears, antibiotics, or corticosteroids [ 79 , 91 , 92 ]. Several randomized studies suggest that SE treatment leads to an improved tear film stability and subjective comfort [ 29 , 69 , 83 , 88 , 91 , 93 , 94 ] by determining a faster epithelial healing time and a better corneal transparency without increase of vascularization or fibrosis. Moreover, several data have confirmed the safety and the almost absolute absence of toxic and side effects, especially in severe case of DES or in PED (except those related to an improper handling).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, several data have confirmed the safety and the almost absolute absence of toxic and side effects, especially in severe case of DES or in PED (except those related to an improper handling). A critical point of these published studies concerns the number of patients enrolled which are recurrently less than 100 [ 4 , 13 , 16 , 35 , 38 , 39 , 43 , 84 , 85 , 95 , 96 ] and the almost absence of long follow-up studies [ 69 ]. On the other hand, the evaluation of the ongoing studies on this therapy showed that the newer fields of clinical research are focusing on alternatives to SE like CBS.…”

Section: Discussionmentioning

confidence: 99%

Human Serum Eye Drops in Eye Alterations: An Insight and a Critical Analysis

Pascale¹,

Lanza

Sommese³

et al. 2015

Journal of Ophthalmology

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Human serum contains a physiological plethora of bioactive elements naturally released by activated platelets which might have a significant effect on the regeneration of corneal layers by stimulating the cell growth. This mechanism supported the use of human serum eye drops in some ocular diseases associated with dystrophic changes and alterations of the tear film, such as persistent corneal epithelial defects and dry eye syndrome. We focused our effort on potential benefits and limitations of the use of human serum eye drops when conventional therapies failed. We reviewed the recent literature by reporting published studies from 2010 to 2014. Despite the limited evaluated study populations, most of the clinical studies have confirmed that serum eye drop therapy is effective in corneal healing by reducing ocular symptom, particularly during the short-term follow-up. In addition, three recent published studies have shown the efficacy of the serum eye drop therapy in comparison to traditional ones in intractable patients. Besides, reported ongoing clinical studies confirmed the open debate regarding the use of biologic tools for cornea regeneration. Results from these studies might open novel challenges and perspectives in the therapy of such refractory patients.

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Plasma rico en plaquetas en superficie ocular

Riestra

Alonso-Herreros

Merayo‐Lloves

2016

Archivos de la Sociedad Española de Oftalmología

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Evaluación de la efectividad del colirio de suero autólogo en el tratamiento de patologías oculares

Abstract: The treatment with 100% autologous serum eye drops improved ocular symptoms for most patients.

Cited by 9 publications

References 10 publications

Topical 100% Serum Eye Drops for Treating Corneal Epithelial Defect after Ocular Surgery

Topical 100% Serum Eye Drops for Treating Corneal Epithelial Defect after Ocular Surgery

Human Serum Eye Drops in Eye Alterations: An Insight and a Critical Analysis

Plasma rico en plaquetas en superficie ocular

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