Euthyroid Thyroperoxidase Antibody Positivity during Pregnancy, to Treat or Not to Treat?

Korevaar, Tim I M

doi:10.3803/enm.2022.301

Cited by 4 publications

(3 citation statements)

References 32 publications

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“…However, the anti-TPO Abs in this study were positive in only about 58.9% of the samples, which may be due to the small sample size. Likewise, we found that a positive anti-TPO Abs state could not be predicted by age or gender, despite previous studies suggesting that older age and a positive family history were risk factors for anti-TPO Ab positivity [11].…”

Section: Discussioncontrasting

confidence: 99%

“…While anti-TPO Abs in patients with AITD can fix complement, destroy thyroid cells, and competitively inhibit enzymatic activity [ 10 ], the risk factors for anti-TPO Abs presence in GD include a higher age, iodine deficiency or excess, a family or personal history of AITD, along with idiopathic and autoimmune causes. Furthermore, paradoxically, smoking and pregnancy appear to decrease the risk of positive anti-TPO Abs [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

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The Clinical Implications of Anti-thyroid Peroxidase Antibodies in Graves’ Disease in Basrah

Alhubaish¹,

Alibrahim²,

Mansour³

2023

Cureus

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BackgroundGraves' disease (GD) is an autoimmune disease, with thyrotropin receptor antibodies (TRAbs) being the most important cause in the pathogenesis. The aim of this study is to assess the clinical significance of anti-TPO Abs in GD. MethodsA retrospective study was conducted at the Faiha specialized Diabetes, Endocrine, and Metabolism Center (FDEMC) in Basrah during the period between December 2021 and December 2022. A total of 141 patients with GD were involved in this study, and of them, 97 (68.8%) were women. They were divided into two groups: patients with positive and negative anti-TPO Abs groups. ResultsPositive anti-TPO Abs were seen in 83 patients (58.9%) with GD. Pretreatment-free thyroxine level (ng/dL) was higher in the anti-TPO Abs positive GD patients than in those with negative antibodies (3.7±0.2 versus 3.0±0.2 with a p=0.021). Similarly, higher TRAb titers (IU/ml) at baseline were also seen in patients with positive anti-TPO Abs (9.8±0.7 versus 6.8±0.8) with a p=0.008. Giraffe appearance on thyroid ultrasound was more common in the group with positive anti-TPO Abs as compared to patients with negative anti-TPO Abs: 20 (87.0%) versus 3 (13.0%) with a p=0.005. A higher anti-TPO Abs titer (IU/mL) was associated with a baseline TRAb level of more than 6.4 IU/mL, and giraffe appearance on thyroid ultrasound (206.5±20.0 p-value<0.0001 and 228.0±35.3 p value=0.007, respectively). ConclusionA positive anti-TPO Abs in GD is associated with a high TRAb titer and free T4 level at baseline, as well as a giraffe appearance on thyroid ultrasound.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Clinical Implications of Anti-thyroid Peroxidase Antibodies in Graves’ Disease in Basrah

Alhubaish¹,

Alibrahim²,

Mansour³

2023

Cureus

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“…Because thyroid peroxidase and thyroglobulin antibodies belong to the immunoglobulin G class of antibodies, they pass the placental barrier and are often detectable in fetal plasma during pregnancy and during the first several weeks of postnatal life [24]. However, they do not seem to have a meaningful impact on fetal and neonatal thyroid function [25], and our findings are in line with this commonly accepted view.…”

Section: Discussionsupporting

confidence: 87%

The Impact of Maternal Hypothyroidism during Pregnancy on Minipuberty in Boys

Kowalcze,

Krysiak,

Obuchowicz

2023

JCM

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Minipuberty is a period of increased reproductive axis activity in infancy, which seems to be implicated in the postnatal development of male genital organs. Impaired thyroid function during pregnancy is associated with an increased risk of prenatal, perinatal, and postnatal complications. The aim of this study was to investigate whether the presence of hypothyroidism during pregnancy modulates the course of male minipuberty. We compared three matched groups of male infants: sons of women with hypothyroidism uncontrolled or poorly controlled during pregnancy (group A), male offspring of women treated over the entire pregnancy with adequate doses of levothyroxine (group B), and sons born to women with no evidence of thyroid disease (group C). Salivary levels of testosterone, androstenedione, dehydroepiandrosterone sulfate, estradiol, progesterone, and 17-hydroxyprogesterone, as well as urine concentrations of FSH and LH, were assessed once a month in the first 6 months of life, and once every two months between months 6 and 12. Gonadotropin and testosterone levels during the first 6 months of life were lower in group A than in groups B and C. Differences in testosterone and gonadotropin levels were accompanied by similar differences in penile length and testicular volume. Concentrations of the remaining hormones did not differ between the study groups. The obtained results suggest that untreated or undertreated maternal thyroid hypofunction in pregnancy has an inhibitory effect on postnatal activation of the hypothalamic-pituitary-testicular axis and genital organ development in their male offspring.

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Research Progress on the Influence of Autoimmune Thyroid Disease on Pregnancy Outcome

李

2023

ACM

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Euthyroid Thyroperoxidase Antibody Positivity during Pregnancy, to Treat or Not to Treat?

Cited by 4 publications

References 32 publications

The Clinical Implications of Anti-thyroid Peroxidase Antibodies in Graves’ Disease in Basrah

The Clinical Implications of Anti-thyroid Peroxidase Antibodies in Graves’ Disease in Basrah

The Impact of Maternal Hypothyroidism during Pregnancy on Minipuberty in Boys

Research Progress on the Influence of Autoimmune Thyroid Disease on Pregnancy Outcome

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