EUS-guided FNA of centrally located lung tumours following a non-diagnostic bronchoscopy

Annema, Jouke T.; Veselic, Maud; Rabe, Klaus F.

doi:10.1016/j.lungcan.2004.11.017

Cited by 91 publications

(63 citation statements)

References 13 publications

(17 reference statements)

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“…The sensitivity of EUS was 96.7% when only the visualised masses were considered, but this value dropped to 80.8% when the 11 nonvisualised masses were also taken into account. ANNEMA et al [64] conducted a prospective study with 32 patients to assess the feasibility and diagnostic yield of EUS-FNA for the diagnosis of centrally located lung tumours following a nondiagnostic bronchoscopy. EUS-FNA provided a diagnosis of malignancy in 97% of patients.…”

Section: Recommendationmentioning

confidence: 99%

“…In 39% of the patients, EUS-FNA not only established the diagnosis of lung cancer, but also staged patients as having T4 disease, based on tumour invasion; however, the latter was not verified surgically. None of the included patients had mediastinal lymph node involvement at CT scan [64]. VARADARAJULU et al [50] conducted a retrospective study including 18 patients who had undergone EUS-FNA of a lung mass abutting the oesophageal wall.…”

Section: Recommendationmentioning

confidence: 99%

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Combined endobronchial and oesophageal endosonography for the diagnosis and staging of lung cancer

et al. 2015

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Section: Recommendationmentioning

confidence: 99%

Section: Recommendationmentioning

confidence: 99%

Combined endobronchial and oesophageal endosonography for the diagnosis and staging of lung cancer

et al. 2015

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“…In a prospective study of 32 patients with suspected lung cancer and a primary tumor located adjacent to the esophagus, intrapulmonary masses were detected in all patients, and the diagnosis of lung cancer was established in 97% of patients. 6 In another small retrospective study, EUS identified and diagnosed all periesophageal pulmonary masses. 7 Once the primary tumor has been identified, EUS can help to define mediastinal invasion, which includes involvement of mediastinal structures such as left atrium, large central vessels, esophagus, and vertebrae by the intrapulmonary tumor.…”

Section: Role In Primary Tumor (T) Evaluation and Mediastinal Invasiomentioning

confidence: 99%

Role of endoscopic ultrasound in non-small cell lung cancer

Bhatia

Puri

2016

Int J Gastrointest Interv

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Lung carcinoma is a common cause of mortality and morbidity worldwide. Non-small cell lung cancer (NSCLC) accounts for majority of cases worldwide. Accurate staging of NSCLC is of paramount importance due to marked difference in survival and management strategies between stage II and III of the disease. The staging methods have evolved from invasive thoracotomies and mediastinoscopies to relatively non-invasive complete mediastinal staging by combination of endoscopic ultrasound (EUS) and endoscopic bronchial ultrasound (EBUS). EUS also provides information about mediastinal invasion and liver/adrenal metastasis. Future role of EUS include providing tissue for molecular targeted therapy.

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“…EUS-FNA might also be used in some cases for staging of distant metastasis (M1), as in the presence of suspected metastases to the left lobe of the liver and/or to the left adrenal gland (15). Further indications to EUS-FNA are represented by the presence of pulmonary lesions adjacent to the esophagus (8,(16)(17)(18). More difficult is the diagnosis with EUS-FNA of mediastinal lymphoproliferative processes, because of the frequent need in these cases for histological samples obtained by extensive surgical techniques (19).…”

Section: Indications and Contraindicationsmentioning

confidence: 99%

“…In these cases, the diagnostic yield for EUS-FNA was 100%, in the absence of complications. The following year, a prospective study was published (17), which included patients with suspected lung cancer adjacent to or near the esophagus (less than 1 cm) already subject to a non-diagnostic bronchoscopy, none of the patients having mediastinal nodal enlargement at the CT scan of the chest. The rationale behind the work was the high percentage of failures diagnostic bronchoscopy in central pulmonary neoplasms (30%) (34), associated with invasiveness and the risk of complications of alternative methods used in these cases, as CT-guided biopsy with pneumothorax in 25-45% of cases (35,36).…”

Section: Diagnosis Of Mediastinal or Intrapulmonary Massesmentioning

confidence: 99%

Transesophageal endoscopic ultrasound (EUS) in pulmonary medicine

Romagnoli¹

2013

SOB

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SummaryEndoscopic ultrasound (EUS) is a safe and minimally invasive procedure, allowing ultrasound-guided needle aspirates in real-time, with high-sensitivity diagnostics. EUS is an instrument available to the pulmonologist for the diagnosis of mediastinal neoplasms, benign and malignant, including the mediastinal lymph node staging of non-small cell lung cancer (NSCLC), with a specific sensitivity up to 90%. EUS allows to detect and to sample even small lesions with a diameter of 3 mm, which are not visible at usual imaging. The most recent guidelines on mediastinal nodal staging of lung cancer report endoscopic and transbronchial ultrasound (EUS and EBUS) as a viable and valid minimally invasive alternative to the "classical" surgical staging with mediastinoscopy, resulting in significant savings in diagnostic invasive surgical procedures, and unnecessary thoracotomy, with a consequent high economical impact. EUS-FNA, as EBUS-TBNA, has been shown to be able to give in one time the diagnosis, the typing, staging, and genotyping of lung cancer with a single diagnostic procedure. However, it must be highlighted that in the mediastinal nodal re-staging of NSCLC, the sensitivity of EUS-FNA significantly decreases, being <50%. Therefore, in all cases of negativity at the re-staging a surgical mediastinoscopy should be performed before therapeutical decisions. EUS should be performed in referral centres, so patients should be referred to centres of reference for a complete endoscopic staging with EBUS/ EUS. All patients, except those with a known pathologic esophageal stenosis, might be investigated by EUS, even on an outpatient basis, in mild sedation with midazolam, or deep sedation with anaesthesia care based on the internal structure organization, and complications are very rare.

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EUS-guided FNA of centrally located lung tumours following a non-diagnostic bronchoscopy

Cited by 91 publications

References 13 publications

Combined endobronchial and oesophageal endosonography for the diagnosis and staging of lung cancer

Combined endobronchial and oesophageal endosonography for the diagnosis and staging of lung cancer

Role of endoscopic ultrasound in non-small cell lung cancer

Transesophageal endoscopic ultrasound (EUS) in pulmonary medicine

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