EUS-guided FNA in diagnosing pancreatic lesions: Strength and cytological spectrum

Nigam, Neha; Rastogi, Archana; Bhatia, Vikram; Sureka, Binit; Jain, Priyanka; Bihari, Chhagan

doi:10.4103/joc.joc_5_18

Cited by 4 publications

(1 citation statement)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NAB has been used not only to improve the diagnostic efficacy 12 but also to evaluate molecular modifications in DNA, RNA, and protein as prognostic and predictive biomarkers. [13][14][15][16] The major advantage of using NAB for these tests is that a cytologic diagnosis can be provided even for patients with nonresectable tumors to inform therapeutic interventions.…”

Section: Discussionmentioning

confidence: 99%

Keratin 17 testing in pancreatic cancer needle aspiration biopsies predicts survival

Roa‐Peña

Babu

Leiton

et al. 2021

Cancer Cytopathology

View full text Add to dashboard Cite

BACKGROUND:Although pancreatic ductal adenocarcinoma (PDAC) has one of the lowest 5-year survival rates of all cancers, differences in survival exist between patients with clinically identical characteristics. The authors previously demonstrated that keratin 17 (K17) expression in PDAC, measured by RNA sequencing or immunohistochemistry (IHC), is an independent negative prognostic biomarker. Only 20% of cases are candidates for surgical resection, but most patients are diagnosed by needle aspiration biopsy (NAB). The aims of this study were to determine whether there was a correlation in K17 scores detected in matched NABs and surgical resection tissue sections and whether K17 IHC in NAB cell block specimens could be used as a negative prognostic biomarker in PDAC. METHODS: K17 IHC was performed for a cohort of 70 patients who had matched NAB cell block and surgical resection samples to analyze the correlation of K17 expression levels. K17 IHC was also performed in cell blocks from discovery and validation cohorts. Kaplan-Meier and Cox proportional hazards regression models were analyzed to determine survival differences in cases with different levels of K17 IHC expression. RESULTS: K17 IHC expression correlated in matched NABs and resection tissues. NAB samples were classified as high for K17 when ≥80% of tumor cells showed strong (2+) staining. High-K17 cases, including stagematched cases, had shorter survival. CONCLUSIONS: K17 has been identified as a robust and independent prognostic biomarker that stratifies clinical outcomes for cases that are diagnosed by NAB. Testing for K17 also has the potential to inform clinical decisions for optimization of chemotherapeutic interventions.

show abstract

Section: Discussionmentioning

confidence: 99%

Keratin 17 testing in pancreatic cancer needle aspiration biopsies predicts survival

Roa‐Peña

Babu

Leiton

et al. 2021

Cancer Cytopathology

View full text Add to dashboard Cite

show abstract

Classification of endoscopic ultrasound guided fine needle aspiration cytology of pancreatic space occupying lesions by Papanicolaou Society of Cytopathology System: A five year study

Chaudhary¹,

Banga²,

Sakhuja³

et al. 2022

Diagnostic Cytopathology

View full text Add to dashboard Cite

Background: Majority of the pancreatic cancer patients present at an advanced stage and have poor 5 year survival rate. Thus, there is a need for early detection of pancreatic cancer with the initiation of the therapy. Materials& Methods: This is a retrospective study including all the endoscopic ultrasound guided (EUS) guided pancreatic FNAs from 2016 to 2020. The aspirate smears were analyzed and classified according to The Papanicolaou Society of Cytopathology System for Reporting Pancreaticobiliary Cytology (PSCPC).Results: A total of 245 EUS guided FNAs from pancreatic lesions were included.Cyto-histological correlation was done wherever available. Category I (non diagnostic) accounted for 40 cases (16%) cases, Category II (negative) comprised of 44 cases (18%); and Category III (Atypical) had 5 cases (2%). Category IV neoplastic-benign category included 3 cases of serous cystadenoma, while neoplastic-others category included pancreatic neuroendocrine tumors (n = 21), solid pseudo-papillary neoplasms (SPEN) (n = 12) and mucinous cystic neoplasms (n = 4). A total of 7 cases (2.8%) were reported in Category V (Suspicious). A diagnosis of adenocarcinoma (Category VI) was rendered in 105 cases (42.8%) cases. Rarer types included non Hodgkins lymphoma (n = 3) and one case of primary undifferentiated carcinoma with osteoclastic giant cells. Cyto-histological correlation in all categories was available in 58 cases with 8 false negative cases. Thus overall sensitivity of EUS guided FNAC was found to be 87.8% with a diagnostic yield of 83.6% while sensitivity in diagnosing adenocarcinoma was 96.9%. Conclusion:The present study highlights the spectrum of EUS guided FNA of pancreatic lesions in a subset of North Indian population and classified them according to PSCPC. EUS guided FNAC is a sensitive investigation which plays a crucial role in confirming the diagnosis of pancreatic space occupying lesions (SOLs) in advanced stage.

show abstract

Undifferentiated Pancreatic Carcinoma with Osteoclast-like Giant Cells: A Case Report

Jeon,

So,

Koo

et al. 2023

Korean J Pancreas Biliary Tract

View full text Add to dashboard Cite

show abstract

EUS-guided FNA in diagnosing pancreatic lesions: Strength and cytological spectrum

Cited by 4 publications

References 22 publications

Keratin 17 testing in pancreatic cancer needle aspiration biopsies predicts survival

Keratin 17 testing in pancreatic cancer needle aspiration biopsies predicts survival

Classification of endoscopic ultrasound guided fine needle aspiration cytology of pancreatic space occupying lesions by Papanicolaou Society of Cytopathology System: A five year study

Undifferentiated Pancreatic Carcinoma with Osteoclast-like Giant Cells: A Case Report

Contact Info

Product

Resources

About