EUS-guided FNA for diagnosis of solid pancreatic neoplasms: a meta-analysis

Hewitt, Michael; McPhail, Mark; Possamai, Lucia; Dhar, Ameet; Vlavianos, Panagiotis; Monahan, Kevin

doi:10.1016/j.gie.2011.08.049

Cited by 647 publications

(510 citation statements)

References 46 publications

(21 reference statements)

Supporting

Mentioning

458

Contrasting

Unclassified

Order By: Relevance

“…Usually the material obtained can serve for cytology, when the sample is arranged on a slide, with a sensitivity for diagnosis of 85-86% [8,9] and limited value for immunohistochemistry. More rarely, the samples are analyzed J Gastrointestin Liver Dis, June 2016 Vol.…”

Section: Endoscopic Ultrasound ( E U S ) -G U I D E D B I O P S Y I Nmentioning

confidence: 99%

Performance of the Standard 22G Needle for Endoscopic Ultrasound-guided Tissue Core Biopsy in Pancreatic Cancer

Seicean

Gheorghiu

Zaharia

et al. 2016

JGLD

View full text Add to dashboard Cite

Background & Aim: Endoscopic ultrasonography (EUS) and EUS-guided fine-needle aspiration (EUS-FNA) are considered good tools for the diagnosis of pancreatic cancer and for obtaining material for cytology or histology. The accuracy of EUS-FNA can rise to 85-95%, but it is lower in cases with a chronic pancreatitis background or with previous biliary stenting. We aimed to establish the diagnostic yield of the visible length of the core biopsy samples in pancreatic cancer by using one single type of standard 22G needle and to evaluate the factors which can influence the results. Method: EUS-FNA was performed by using a 22G standard needle on patients prospectively recruited with the suspicion of pancreatic masses on transabdominal ultrasound or CT scan over a period of eight months. The number of passes was limited by the length of the core obtained. The final diagnosis was based on EUS-FNA or hepatic biopsy for their metastasis or by follow up every three month by imaging methods. Results: The study included 118 patients. Previous stents were present in 10 patients and chronic pancreatitis features were found in 3 patients. The procedure sensitivity was 89% and the global accuracy was 89%. The presence of biliary stents did not impede the accuracy of results. The number of passes did not influence the results. Conclusions: The diagnostic rate of core biopsy by using 22G needles had a high accuracy and it is safe when the length of core dictates the number of passes. The presence of biliary stents did not influence the results. Abbreviations: AUC: area under the curve; EUS: endoscopic ultrasonography; EUS-FNA: fine needle aspiration under endosonographic guidance; FNA: fine needle aspiration; INR: international normalised ratio; OR: odds ratio.

show abstract

Section: Endoscopic Ultrasound ( E U S ) -G U I D E D B I O P S Y I Nmentioning

confidence: 99%

Performance of the Standard 22G Needle for Endoscopic Ultrasound-guided Tissue Core Biopsy in Pancreatic Cancer

Seicean

Gheorghiu

Zaharia

et al. 2016

JGLD

View full text Add to dashboard Cite

show abstract

“…6,11,45 It has since become standard of care to obtain EUS-FNA of SPL based on its cytological diagnostic sensitivity exceeding 80% in cases without underlying chronic pancreatitis. 3,6,11,46,47 Recently, a meta-analysis of 33 studies by Hewitt et al 48 revealed a sensitivity of 85% (95% CI = 0.84-0.86). Beyond the reliability of EUS-FNA, it also remains a safe procedure, with multiple studies demonstrating a complication rate less than 3%.…”

Section: Confocal Laser Endomicroscopymentioning

confidence: 99%

Novel diagnostic and therapeutic modalities using endoscopic ultrasound in pancreatic disease

Luthra

Mishra

2017

Int J Gastrointest Interv

View full text Add to dashboard Cite

show abstract

“…Despite numerous studies addressing these issues, many endoscopists are still perplexed about the nature of the best practices needed to ensure optimal results, in particular with regard to the need for on-site cytopathology for skilled and experienced endosonographers practicing at a high-volume center. To date, multiple meta-analyses have confirmed the diagnostic accuracy, cost-effectiveness, accuracy, and safety of EUS-FNA for solid pancreatic lesions [8][9][10][11][12]. Moreover, structured literature reviews have concluded that rapid on-site evaluation (ROSE) improves diagnostic accuracy [8,9].…”

mentioning

confidence: 95%