European viper envenomation recorded by French poison control centers: A clinical assessment and management study

Jollivet, V.; Hamel, Jean François; Haro, Luc de; Labadie, Magali; Sapori, Jean-Marc; Cordier, L.; Villa, Antoine; Nisse, Patrick; Puskarczyk, Emmanuel; Berthelon, Laurent; Harry, P.; Boels, D.

doi:10.1016/j.toxicon.2015.09.039

Cited by 28 publications

(33 citation statements)

References 21 publications

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“…In a group of 17 patients from the current study, LMWH was administered as prophylaxis in patients with marked oedema of the lower extremity. This indication has also been reported by others [12,17].…”

Section: Discussionsupporting

confidence: 90%

“…In a group of 15 patients from north-eastern Poland, INR was increased in only one case, which is in line with this study [16]. A nationwide French study [12] also did not reported serious hypocoagulation in patients after a V. berus bite. A case of pulmonary embolism in one V. berus bite patient has been reported by other French authors [18].…”

Section: Discussionsupporting

confidence: 89%

“…A case of pulmonary embolism in one V. berus bite patient has been reported by other French authors [18]. Such complications were not observed in either the current study nor the large study performed in France [12]. In a group of 17 patients from the current study, LMWH was administered as prophylaxis in patients with marked oedema of the lower extremity.…”

Section: Discussionsupporting

confidence: 41%

“…It analyses one of the largest data collections from a single centre, whereas other larger studies have been rather nationwide studies [11,12,13]. The data were collected during 14 years and based upon clinical records.…”

Section: Discussionmentioning

confidence: 99%

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Is coagulopathy a common consequence of a Vipera berus bite? A retrospective single centre study

Dyląg-Trojanowska¹,

Hodorowicz-Zaniewska

Zybaczynska

et al. 2018

Ann Agric Environ Med.

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Introduction. The Vipera berus (common viper) is the only species of venomous snake found in Poland. The aim of this study was to determine to what extent coagulopathy has occurred as a post-bite complication. Materials and method. The medical records of 138 adult patients in the Sucha Beskidzka hospital with the diagnosis of snake bite between 2001-2014 were retrospectively analyzed. Demographic, clinical and laboratory data were collected. Antivenom was given to all patients, except one, with snake bites, but laboratory test were taken prior to administration of antivenom. Obtained results were compared to those of the control group, composed of 176 adults hospitalized in the same period for an elective laparoscopic cholecystectomy. Results. The mean platelet count in the study group was 239.94×109/L (SD=56.56) and 248.77×109/L (SD=57.82) in the control group. In 98% of the study group and 100% of the control group the platelet value (PLT) fell within laboratory norms (130 to 420×109/L), 2 patients after snake bites had a PLT lower than normal, and thrombocytosis was not observed in either group. A reference range of 0.85-1.3 INR below normal was found in 2 patients in the study group and 15 from the control group, while values above the normal range were found in 8 patients (6.7%) from the snake bite group and no patients from the control group. In the study group, the INR ranged from 0.78-1.43 with a mean of 1.046 (SD=0.14), while in the control group the range was from 0.79-1.28, with a mean of 0.95 (SD=0.08). There was a significant difference in INR between the study and control groups (p<0.0001). Conclusions. The bite from V. berus does not result in severe thrombocytopenia, with only a moderate increase in INR values observed in about 7% of patients.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 41%

Section: Discussionmentioning

confidence: 99%

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Is coagulopathy a common consequence of a Vipera berus bite? A retrospective single centre study

Dyląg-Trojanowska¹,

Hodorowicz-Zaniewska

Zybaczynska

et al. 2018

Ann Agric Environ Med.

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“…Snakebite victims have recently been treated with Viperfav™ (Aventis Pasteur, MSD, Lyon, France), a formulation containing polyvalent equine F(ab’) 2 fragments as an active principle against V. aspis , V. berus and V. a. ammodytes . Viperfav™ has been proven to be safe and effective for rapidly counteracting the pathophysiological manifestations that follow V. aspis and V. berus bites [2,3,4,5,6,7]. Pharmacokinetic and therapeutic efficacy against V. a. ammodytes venom-induced toxicity in human has not been described, although neutralisation efficacy has been proven preclinically.…”

Section: Introductionmentioning

confidence: 99%

A Single Dose of ViperfavTM May Be Inadequate for Vipera ammodytes Snake Bite: A Case Report and Pharmacokinetic Evaluation

Kurtović

Brvar

Grenc

et al. 2016

Toxins

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ViperfavTM is a commercial F(ab’)2 antivenom prepared against European vipers venom. It is safe and effective for treating envenomation caused by Vipera aspis and Vipera berus. Therapeutic efficacy for treating Vipera ammodytes ammodytes (V. a. ammodytes) envenoming has not been yet described, although protective efficacy has been demonstrated in preclinical studies. We report on a 32-year-old man bitten by V. a. ammodytes who was treated with Viperfav™. Viperfav™ promptly reduced local extension and improved systemic pathological signs, but 24 h after the incident a recurrence of thrombocytopenia occurred despite a favorable pharmacokinetic profile with systemic clearance (1.64 (mL·h−1)·kg−1) and elimination half-life (97 h) among the highest ever reported. The recommended dose of Viperfav™ for V. aspis and V. berus bites may be inadequate for serious V. a. ammodytes envenomations. Following V. a. ammodytes bite, serial blood counts and coagulation profiles should be performed to help guide Viperfav™ treatment, along with supplemental administration as indicated.

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Antivenin Viperidae

2015

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European viper envenomation recorded by French poison control centers: A clinical assessment and management study

Cited by 28 publications

References 21 publications

Is coagulopathy a common consequence of a Vipera berus bite? A retrospective single centre study

Is coagulopathy a common consequence of a Vipera berus bite? A retrospective single centre study

A Single Dose of ViperfavTM May Be Inadequate for Vipera ammodytes Snake Bite: A Case Report and Pharmacokinetic Evaluation

Antivenin Viperidae

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