European Union Funding of Research on Airway Diseases

Kogan, Grigorij; Vidal-Ragout, María; Trzaska, Dominika; Crisafulli, Aldo; Berkouk, Karim; Hogan, Stéphane; Hanrahan, Finnian; Laang, Hannu; Matthiessen, Line

doi:10.1016/b978-0-12-813471-9.00033-5

Cited by 1 publication

(1 citation statement)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The “Big five” respiratory disorders constituting chronic obstructive pulmonary disorders (COPD), asthma, tuberculosis, acute respiratory infections and lung cancer are more lethal (Kogan et al . 2019 ). Lungs have been a home to abundant noncultivable bacteria that are disrupted during the respiratory disorders that have been reported in COPD (Wang and Bafadhel 2016 ), asthma (Loverdos and Bellos 2019 ), lung cancer (Liu and Ma 2020 ), respiratory viral infections (Hanada and Pirzadeh 2018 ), bronchiectasis (Richardson and Dicker 2019 ), pneumonia (Hong et al .…”

Section: Introductionmentioning

confidence: 99%

Meta-analysis of the microbial biomarkers in the gut–lung crosstalk in COVID-19, community-acquired pneumonia and Clostridium difficile infections

Aishwarya

Gunasekaran

2022

Letters in Applied Microbiology

View full text Add to dashboard Cite

Respiratory infections are the leading causes of mortality and the current pandemic COVID‐19 is one such trauma that imposed catastrophic devastation to the health and economy of the world. Unravelling the correlations and interplay of the human microbiota in the gut–lung axis would offer incredible solutions to the underlying mystery of the disease progression. The study compared the microbiota profiles of six samples namely healthy gut, healthy lung, COVID‐19 infected gut, COVID‐19 infected lungs, Clostridium difficile infected gut and community‐acquired pneumonia infected lungs. The metagenome data sets were processed, normalized, classified and the rarefaction curves were plotted. The microbial biomarkers for COVID‐19 infections were identified as the abundance of Candida and Escherichia in lungs with Ruminococcus in the gut. Candida and Staphylococcus could play a vital role as putative prognostic biomarkers of community‐acquired pneumonia whereas abundance of Faecalibacterium and Clostridium is associated with the C. difficile infections in gut. A machine learning random forest classifier applied to the data sets efficiently classified the biomarkers. The study offers an extensive and incredible understanding of the existence of gut–lung axis during dysbiosis of two anatomically different organs.

show abstract