European solvent industry group generic exposure scenario risk and exposure tool

Abstract

The European Solvents Industry Group (ESIG) Generic Exposure Scenario (GES) Risk and Exposure Tool (EGRET) was developed to facilitate the safety evaluation of consumer uses of solvents, as required by the European Union Registration, Evaluation and Authorization of Chemicals (REACH) Regulation. This exposure-based risk assessment tool provides estimates of both exposure and risk characterization ratios for consumer uses. It builds upon the consumer portion of the European Center for Ecotoxicology and Toxicology of Chemicals (ECETOC) Targeted Risk Assessment (TRA) tool by implementing refinements described in ECETOC TR107. Technical enhancements included the use of additional data to refine scenario defaults and the ability to include additional parameters in exposure calculations. Scenarios were also added to cover all frequently encountered consumer uses of solvents. The TRA tool structure was modified to automatically determine conditions necessary for safe use. EGRET reports results using specific standard phrases in a format consistent with REACH exposure scenario guidance, in order that the outputs can be readily assimilated within safety data sheets and similar information technology systems. Evaluation of tool predictions for a range of commonly encountered consumer uses of solvents found it provides reasonable yet still conservative exposure estimates.

Consumer exposure modelling under REACH: Assessing the defaults

“…In agreement with our findings, Zaleski et al (2014) observed that EGRET was generally less conservative than TRA, while retaining conservatisms against the ConsExpo estimate, when evaluating other product categories (air care products, coatings, fuels and cleaning products). These authors, however, did not include glues in their evaluation, the product category that appeared to be the one with the least conservative estimates in our evaluation.…”

“…The data in Table 3 clearly show that the amount of product per application was often reduced in EGRET, a finding that is in agreement with the description of the tool (Zaleski et al, 2014). For hobby glue and glass cleaner, the differences in product amounts used are very small.…”

“…In addition, the article by Zaleski et al (2014) was used as a source, although the authors did not intend to justify default values.…”

Exploring Global Exposure Factors Resources for Use in Consumer Exposure Assessments

“…ECHA (2011) produced a cleaning product example scenario [ 123 ]. In addition, scenarios for multiple product types are found in the Specific Consumer Exposure Determinants and in modeling tools like [ 91 , 92 , 93 ]: the U.S. EPA’s Exposure and Fate Assessment Screening Tool Version 2014 [ 128 ], ConsExpo [ 129 ], the Targeted Risk Assessment tool (TRA) [ 130 , 131 , 132 , 133 ], Chemical Safety Assessment and Reporting tool (CHESAR) [ 134 ], REACH Consumer Exposure Assessment Tool (REACT) [ 135 ], European Solvents Industry Group Generic Exposure Scenario Risk and Exposure Tool (EGRET) [ 136 , 137 ] and the Wall Paint Exposure Model [ 138 ].…”

Model framework for integrating multiple exposure pathways to chemicals in household cleaning products

“…Most exposure and epidemiologic studies associated with cleaning product use have not differentiated the outcomes of interest by chemicals, but rather by product type (e.g., surface cleaners), chemical class (e.g., glycol ethers), or chemical functions (e.g., disinfectants). There are several exposure models for cleaning product use, including one developed by the American Cleaning Institute (ACI) and two developed by the U.S. Environmental Protection Agency (U.S. EPA), specifically ‘Exposure and Fate Assessment Screening Tool (E‐FAST)’ and ‘Consumer Exposure Model (CEM)’ Other consumer exposure‐assessment tools were also developed to meet reporting requirements of the European Union's Registration, Evaluation, and Authorization of Chemicals (REACH): ConsExpo (Consumer Exposure) model, ECETOC (European Center for Ecotoxicology and Toxicology of Chemicals) TRA (Targeted Risk Assessment) tool, EGRET (European Solvents Industry Group Generic Exposure Scenario Risk and Exposure Tool), and A.I.S.E. REACT (International Association for Soaps, Detergents and Maintenance Products REACH Exposure Assessment Consumer Tool) .…”