European Society of Veterinary Cardiology screening guidelines for dilated cardiomyopathy in Doberman Pinschers

Doberman pinschers present autoimmunity associated with functional autoantibodies: a model to study the autoimmune background of human dilated cardiomyopathy

“…Dilated cardiomyopathy with a disease cumulative prevalence of 58% (20,30,40,41) is the most common form of cardiomyopathy in Doberman pinschers which “… closely resembles the human form of the disease” (24) and therefore repeatedly suggested for modeling human DCM (18,30). In the final state, as mentioned already in above, DP with DoCM present with typical signs such as congestive heart failure (CHF), arrhythmia, syncope and exercise intolerance very similar as found in human heart failure.…”

“…In parallel, blood was sampled for the measurement of functional autoantibodies. Based on the guidelines of the European Society of Veterinary Cardiology (30), DoCM was diagnosed for dogs with >300 VPC/24h or two subsequent examinations within a year showing between 50 and 300 VPC/24h (31) and echocardiographic indicative for cardiac dysfunction. For that purpose, the left ventricular end-systolic (ESVI) and end-diastolic volume (EDVI) were measured and indexed to body surface area based on Simpson’s method.…”

Breed‐specific reference ranges for standard echocardiographic measurements in salukis

“…Thus, the septum may appear to be falsely hypokinetic, leading to underestimation of the FS. Interpretation of the FS should therefore be done with caution and this variable should probably not be used as a single marker of systolic function, and FS should be interpreted in connection with the breed-specific values (Dukes-McEwan et al 2003, Wess et al 2017.…”

“…, Wess et al . ). Many common echocardiographic variables are presumed to be influenced by breed, and breed‐specific reference ranges are likely to be more accurate than ranges generated from dogs of all‐breeds (Bavegems et al .…”

“…Well-established echocardiographic diagnostic criteria are important for the identification and early diagnosis of cardiac disease in dogs (Dukes-McEwan et al 2003, Meurs 2010, Chetboul & Tissier 2012, Birkegård et al 2016, Wess et al 2017. Many common echocardiographic variables are presumed to be influ-enced by breed, and breed-specific reference ranges are likely to be more accurate than ranges generated from dogs of all-breeds (Bavegems et al 2007, Wess et al 2010, Stephenson et al 2012 letic heart typical for sighthounds (Page et al 1993, Della Torre et al 2000, Cornell et al 2004, Bavegems et al 2007, Seckerdieck et al 2015.…”