European semi-anthropomorphic spine phantom for the calibration of bone densitometers: Assessment of precision, stability and accuracy the European quantitation of osteoporosis study group

Pearson, J; Dequeker, Jan; Henley, Michael V.; Bright, J.E.; Reeve, J.; Kalender, Willi A.; Laval-Jeantet, A. M.; Rüegsegger, P.; Felsenberg, Dieter; Adams, Judith E.; Birkenhäger, J. C.; Braillon, P.; Curiel, Manuel Dı́az; Fischer, M.; Galán, Fernando; Geusens, Piet; Hyldstrup, Lars; Jaeger, P; Jonson, R.; Kalef-Ezras, J.; Kotzki, Pierre‐Olivier; Kröger, Heikki; Lingen, A. van; Nilsson, Sven Erik G.; Osteaux, M; Cano, R. Pérez; Reid, David M.; Reiners, Christoph; Ribot, C.; Schneider, Peter; Slosman, DO; Wittenberg, G.

doi:10.1007/bf02106097

Cited by 103 publications

(48 citation statements)

References 29 publications

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“…Machine variability between centers was monitored using the European Spine Phantom and the pQCT scanners using the European Forearm phantom; where necessary, cross‐calibration was performed 41, 42, 43, 44. Standard manufacturer procedures were followed for daily quality assurance (QA)/quality control (QC) and all phantom and scan analysis were centralized to one center (Manchester Academic Health Sciences & University of Manchester, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK; JEA) for grading, analysis, and collation of a harmonized database.…”

Section: Methodsmentioning

confidence: 99%

Life Course Dietary Patterns and Bone Health in Later Life in a British Birth Cohort Study

Ward

Prentice

Kuh

et al. 2016

Journal of Bone and Mineral Research

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Evidence for the contribution of individual foods and nutrients to bone health is weak. Few studies have considered hypothesis‐based dietary patterns and bone health. We investigated whether a protein‐calcium‐potassium–rich (PrCaK‐rich) dietary pattern over the adult life course, was positively associated with bone outcomes at 60 to 64 years of age. Diet diaries were collected at ages 36, 46, 53, and 60 to 64 years in 1263 participants (661 women) from the MRC National Survey of Health and Development. DXA and pQCT measurements were obtained at age 60 to 64 years, including size‐adjusted bone mineral content (SA‐BMC) and volumetric bone mineral density (vBMD). A food‐based dietary pattern best explaining dietary calcium, potassium, and protein intakes (g/1000 kcal) was identified using reduced rank regression. Dietary pattern Z‐scores were calculated for each individual, at each time point. Individual trajectories in dietary pattern Z‐scores were modeled to summarize changes in Z‐scores over the study period. Regression models examined associations between these trajectories and bone outcomes at age 60 to 64 years, adjusting for baseline dietary pattern Z‐score and other confounders. A consistent PrCaK‐rich dietary pattern was identified within the population, over time. Mean ± SD dietary pattern Z‐scores at age 36 years and age 60 to 64 years were –0.32 ± 0.97 and 2.2 ± 1.5 (women) and –0.35 ± 0.98 and 1.7 ± 1.6 (men), respectively. Mean trajectory in dietary pattern Z‐scores ± SD was 0.07 ± 0.02 units/year. Among women, a 0.02‐SD unit/year higher trajectory in dietary pattern Z‐score over time was associated with higher SA‐BMC (spine 1.40% [95% CI, 0.30 to 2.51]; hip 1.35% [95% CI, 0.48 to 2.23]), and vBMD (radius 1.81% [95% CI, 0.13 to 3.50]) at age 60 to 64 years. No statistically significant associations were found in men. During adulthood, an increasing score for a dietary pattern rich in protein, calcium, and potassium was associated with greater SA‐BMC at fracture‐prone sites in women. This study emphasizes the importance of these nutrients, within the context of the whole diet, to bone health. © 2016 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research (ASBMR).

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Section: Methodsmentioning

confidence: 99%

Life Course Dietary Patterns and Bone Health in Later Life in a British Birth Cohort Study

Ward

Prentice

Kuh

et al. 2016

Journal of Bone and Mineral Research

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“…16 The measurements by different machines were standardised using the European spine phantom and the method described by Pearson and collegues. 17 Next, the BMD values were converted into T-scores by comparison with the mean and standard deviation of the BMD values in a reference population of young healthy women. For example, a T-score of -1 indicates that the BMD of the subject is 1 standard deviation below the mean.…”

Section: Bmd Values and Gold Standardmentioning

confidence: 99%

Selecting regions of interest on intraoral radiographs for the prediction of bone mineral density

Geraets

Verheij²,

Stelt³

et al. 2008

Dentomaxillofacial Radiology

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Objectives: A previous study showed that the trabecular pattern on dental radiographs correlates with femoral and spinal Bone Mineral Density (BMD). The objective of this study was to determine if the correlation is affected by size and location of the region of interest (ROI). Conclusions: This study shows that it is allowed to include parts of neighbouring teeth in the region of interest used to assess the trabecular pattern and predict BMD. This simplifies the process of selecting the ROI because no efforts have to be made to exclude neighbouring teeth. MethodsCombining ROIs of lower and upper jaws improves the prediction of BMD significantly.

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“…where y is measured density and x is specified density, as described by Pearson et al [5]. All bone density measurements were then converted to standardized densities using Eq.…”

Section: Dxa and Cross-calibrationmentioning

confidence: 99%

“…Because the EVOS centres have used densitometers made by different manufacturers, it was important first to cross-calibrate the measurements obtained. An approach to doing this using the Et~opean Spine Phantom (ESP) and its predecessor the ESP prototype (ESPp) has recently been published [4][5][6]. We have found substantial differences in BMD between populations that cannot be accounted for by variations in height, weight or selection bias.…”

Section: Introductionmentioning

confidence: 99%

Population-based geographic variations in dxa bone density in Europe: The evos study

Lunt¹,

et al. 1997

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Abstract. The purpose of this study was to investigate variations in bone density between 16 European populations, 13 of which were participants in the European Vertebral Osteoporosis Study (EVOS). Men and women aged 50-80 years were recruited randomly from local population registers, stratified in 5-year age bands. The other three centres recruited similarly. Random samples of 20-100% of EVOS subjects were invited for dual-energy X-ray absorptiometry (DXA) densitometry of the lumbar spine and/or proximal femur using Hologic, Lunar or Norland pencil beam machines or, in one centre, a Sopha fan.-beam machine. Crosscalibration of the different machines was undertaken using the European Spine Phantom prototype (ESPp). Highly significant differences in mean bone density were demonstrated between centres, giving rise to betweencentre SDs in bone density that were about a quarter of a population SD. These differences persisted when centres using Hologic machines and centres using Lunar machines were considered separately. The centres were ranked differently according to whether male or female subjects were being considered and according to site of measurement (L2-4, femoral neck or femoral trochanter). As expected, bone mineral density (BMD) had a curvilinear relationship with age, and apparent rates of decrease slowed as age advanced past 50 years in both sexes. In the spine, not only did male BMD usually appear to increase with age, but there was a highly significant difference between centres in the age effect in both sexes, suggesting a variability in the impact of osteoarthritis between centres. Weight was consistently positively associated with BMD, but the effects of height and armspan were less consistent. Logmithmic transformation was needed to normalize the regressions of BMD on the independent variates, and after transformation, all sites except the femoral neck in females showed significant increases in SD with age. Interestingly, the effect of increasing weight was to decrease dispersion in proximal femur measurements in both sexes, further accentuating the tendency in women for low body mass index to be associated with osteoporosis as defined by densitometry. It is concluded that there are major differences between BMD values in European population samples which, with variations in anthro~ pometric variables, have the potential to contribute substantially to variations in rates of osteoporotic fracture risk in Europe.

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European semi-anthropomorphic spine phantom for the calibration of bone densitometers: Assessment of precision, stability and accuracy the European quantitation of osteoporosis study group

Cited by 103 publications

References 29 publications

Life Course Dietary Patterns and Bone Health in Later Life in a British Birth Cohort Study

Life Course Dietary Patterns and Bone Health in Later Life in a British Birth Cohort Study

Selecting regions of interest on intraoral radiographs for the prediction of bone mineral density

Population-based geographic variations in dxa bone density in Europe: The evos study

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