European neuroborreliosis: quality of life 30 months after treatment

Eikeland, Randi; Mygland, Åse; Herlofson, Karen; Ljøstad, Unn

doi:10.1111/j.1600-0404.2010.01482.x

Cited by 53 publications

(59 citation statements)

References 31 publications

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“…In contrast, the authors also included patients with LNB who were not treated with antibiotics. Our results are in conflict with results from two other case-control studies [15,16,22]. Eikeland et al report statistically significant differences for quality of life (PCS), fatigue, and depression between 50 patients with LNB and 50 healthy controls.…”

Section: Discussioncontrasting

confidence: 84%

“…As all three studies are also case-control studies, they all suffer from inherent sampling bias. The patients' characteristics in Eikeland et al show that the LNB group included many participants with other relevant conditions, which all could lead to decreased scores on scales for quality of life or in neuropsychological tests (Parkinson's disease, multiple sclerosis, cancer, diabetes, atherosclerosis and previous psychiatric diseases) [15]. All studies apply a variety of tests in two populations, some with several subscores, without adequately considering the increased risk of alpha inflation.…”

Section: Discussionmentioning

confidence: 97%

“…However, evidence for impaired quality of life and increased fatigue for patients with LNB is inconclusive. Some authors report similar findings for quality of life, fatigue and depression in healthy controls [13,14], whereas other authors state considerable differences and impairing deficits in patients with LNB [15,16]. To assess the long-term outcome, residual symptoms and the impact of the disease on quality of life of patients with LNB, we conducted a case-control study including patients from the Medical Center, University of Freiburg, which is located in the southwest part of Black Forest representing a region of endemic Lyme disease in Germany.…”

Section: Introductionmentioning

confidence: 86%

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Quality of life, fatigue, depression and cognitive impairment in Lyme neuroborreliosis

et al. 2015

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The prognosis and impact of residual symptoms on quality of life in patients with Lyme neuroborreliosis (LNB) is subject to debate. The aim of this study was to assess quality of life, fatigue, depression, cognitive impairment and verbal learning in patients with definite LNB and healthy controls in a case-control study. We retrospectively identified all patients diagnosed with definite LNB between 2003 and 2014 in our tertiary care center. Healthy controls were recruited from the same area. Patients and healthy controls were assessed for quality of life [Short Form (36) with subscores for physical and mental components (PCS, MCS)], fatigue (fatigue severity scale), depression (Beck depression inventory), verbal memory and learning and cognitive impairment (mini-mental state examination). 53 patients with definite LNB could be identified, of which 30 partook in the follow-up assessment. Estimates for quality of life, fatigue, depression, verbal memory and cognitive impairment did not differ statistically significantly between 30 patients with LNB and 35 healthy controls. Patients with residual symptoms had lower scores for quality of life (PCS) compared to patients without residual symptoms. Our results do not support the hypothesis that a considerable proportion of patients with antibiotically treated LNB develop a 'post Lyme syndrome' consisting of debilitating fatigue or cognitive impairment or have severe limitations of quality of life. However, some patients experience residual symptoms of LNB.

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Section: Discussioncontrasting

confidence: 84%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 86%

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Quality of life, fatigue, depression and cognitive impairment in Lyme neuroborreliosis

et al. 2015

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“…Third, the antibodies may be a marker of late effects of a previously treated or unrecognised Borrelia infection: so-called post-treatment Lyme disease. This term arose due to a number of patients reporting persistent non-specific health problems after completing treatment (6,9), but the incidence of post-treatment Lyme disease is controversial and its mechanisms unknown (7). While this possibility should be considered in individual patients, it is important to communicate to patients that the symptoms are not due to active infection and that long-term antibiotic treatment is ineffective (10).…”

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confidence: 99%

Kan det være Lyme-nevroborreliose?

Mygland¹

2017

Tidsskriftet

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“…Between 28 and 50 % of those who undergo treatment for Lyme neuroborreliosis develop post-treatment Lyme disease (PTLD), which is marked by fatigue, neuropsychological symptoms and reduced quality of life (12,13). Diagnostic criteria have been proposed for this condition, but its aetiology, diagnosis and clinical significance remain uncertain and controversial (14 -16).…”

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confidence: 99%