European League Against Rheumatism recommendations for calcium pyrophosphate deposition. Part I: terminology and diagnosis

Abstract

New terms for CPPD were agreed and 11 key recommendations for diagnosis of CPPD were developed using research evidence and expert consensus.

Calcium Pyrophosphate Dihydrate Crystal Deposition Disease Simulating Osteoarthrosis of the Knee: A Case Report

“…5,9 Although chondrocalcinosis is most commonly due to CPPD crystals, it is not exclusive of this disease and could appear as an incidental finding or coexist with structural changes that resemble OA. 15 Common findings of OA on radiographs include nonuniform joint space narrowing, osteophyte formation, subchondral cyst formation, and subchondral sclerosis. CPPD is characterized by a radiographic finding of calcification within the articular cartilage (chondrocalcinosis) and periarticular soft tissues and may involve a number of variants ( Table 2).…”

“…5 Although radiographic evidence of synovial calcification can be an effective tool in the diagnosis of CPPD, the absence of calcification does not rule out the diagnosis. 15 Joint aspiration and histologic evaluation of crystals in the synovial fluid by light microscopy, compensated polarized light microscopy, or phase contrast light microscopy are considered the criterion standard in the diagnosis of CPPD. 2 Although joint aspiration with crystal identification is the criterion standard, this test is rarely ever performed in a clinical setting because the exact crystal composition is unlikely to alter either the management or the prognosis.…”

“…15 Although OA is much more prevalent than CPPD, it is important to consider both diagnoses in elderly patients who present with unilateral knee pain. By knowing one's anatomy and through observing the changes that the disease has produced in the anatomy, it is possible to identify the pathologic process(es) that produced those changes.…”

Use of Methotrexate in Patients With Calcium Pyrophosphate Crystal Deposition Disease

“…Они также могут индуцировать широкий спектр клиниче-ских проявлений, включая острые приступы артрита, теносиновиты, бурситы, тендиниты, хронический арт-рит, быстро прогрессирующий остеоартрит (ОА), ком-прессионные синдромы, остеодеструкцию. На сегод-няшний день, в зависимости от имеющейся симптома-тики, выделяют четырек клинических варианта БДПФК: лантонический, или бессимптомный, острый артрит, ОА с ПФК и хронический артрит [4]. Послед-ний, наиболее тяжелый, вариант встречается реже ос-тальных (в 11% случаев), часто протекает как олиго-или полиартрит, характеризуется повышением СОЭ и уров-ня С-реактивного белка (СРБ), может сочетаться с ост-рыми приступами артрита и, особенно в случае пораже-ния суставов кистей, симулировать ревматоидный арт-рит (РА) и другие ревматические заболевания (напри-мер, ревматическую полимиалгию при вовлечении пле-чевых суставов), что обусловливает необходимость под-тверждения диагноза БДПФК путем выявления кри-сталлов ПФК с помощью поляризационной микроско-пии [4,5].…”

Calcium Pyrophosphate Dihydrate Deposition Disease in Young Patients: Two Case Reports

“…7 A primary metabolic disorder or familial predisposition should be considered if CC occurs in patients <55 years, or if there is florid polyarticular CC. 1,8,9 An acute episode of CPPD disease may occur spontaneously or develop after trauma, surgery or a severe medical illness, similar to an attack of gout. Knee is the most commonly involved joint, followed by the wrist, metacarpophalangeal, hips, shoulder, and ankle joints.…”