European Glaucoma Prevention Study: Author reply

Miglior, Stefano; Pfeiffer, Norbert; Zeyen, Thierry; Cunha‐Vaz, José; Torri, Valter; Adamsons, Ingrid

doi:10.1016/j.ophtha.2005.06.020

Cited by 177 publications

(129 citation statements)

References 9 publications

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“…19 No further RCTs of treatment effectiveness for OAG: other than those included in the systematic review and also separately identified by the search strategy, were identified. One additional RCT 253 was identified where participants had ocular hypertension, but this did not meet the inclusion criteria of this specific review and was excluded.…”

Section: Number and Type Of Studies Includedmentioning

confidence: 99%

The clinical effectiveness and cost-effectiveness of screening for open angle glaucoma: a systematic review and economic evaluation

Burr¹,

Mowatt²,

Hernández³

et al. 2007

Health Technol Assess

317

380

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Section: Number and Type Of Studies Includedmentioning

confidence: 99%

The clinical effectiveness and cost-effectiveness of screening for open angle glaucoma: a systematic review and economic evaluation

Burr¹,

Mowatt²,

Hernández³

et al. 2007

Health Technol Assess

317

380

View full text Add to dashboard Cite

show abstract

“…68 IOP is an imperfect surrogate for the clinical outcomes of glaucoma, as disease can progress despite low IOP or remain stable despite IOP levels considered high. [69][70][71] The use of visual fields as an end point is potentially limited by the need for large samples, long follow-up, variability of results, and inconsistency in criteria for defining progression. 72 The absence of regulatory support for other glaucoma end points has been identified as a weakness in exploring candidate agents for neuroprotective therapy and alternative surrogate end points have been sought.…”

Section: Summary and Future Directionsmentioning

confidence: 99%

Assessment of rates of structural change in glaucoma using imaging technologies

Mansouri

Leite

Medeiros

et al. 2011

Eye

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Purpose To review the ability of current imaging technologies to provide estimates of rates of structural change in glaucoma patients.Patients and methods Review of literature. Results Imaging technologies, such as confocal scanning laser ophthalmoscopy (CSLO), scanning laser polarimetry (SLP), and optical coherence tomography (OCT), provide quantifiable and reproducible measurements of the optic disc and parapapillary retinal nerve fibre layer (RNFL). Rates of change as quantified by the rim area (RA) (for CSLO) and RNFL thickness (for SLP and OCT) are related to glaucoma progression as detected by conventional methods (eg, visual fields and optic disc photography). Evidence shows that rates of RNFL and RA loss are significantly faster in progressing compared with nonprogressing glaucoma patients. Conclusion Measurements of rates of optic disc and RNFL change are becoming increasingly precise and individualized. Currently available imaging technologies have the ability to detect and quantify progression in glaucoma, and their measurements may be suitable end points in glaucoma clinical trials.

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“…In this study, treatment reduced the IOP by 15-22% throughout the 5 years of the trial, and interestingly an IOP lowering effect of between 9 and 19% reduction in IOP was observed in the placebo group. 17 Combining these data and data from eight smaller trials a Cochrane systematic review and meta-analysis by Vass and colleagues evaluating different topical medications against placebo or untreated controls showed about a 40% reduction in the incidence of glaucomatous visual field defects with treatment at five years (odds ratio 0.62 (95% confidence interval 0.5 to 0.8) for people with ocular hypertension. 18 In the UK there is great variability in clinical practice regarding standards of care (follow-up and treatment) of ocular hypertension.…”

Section: Resultsmentioning

confidence: 99%

Surveillance for ocular hypertension: an evidence synthesis and economic evaluation

2012

Clinical Governance: An International Journal

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European Glaucoma Prevention Study: Author reply

Cited by 177 publications

References 9 publications

The clinical effectiveness and cost-effectiveness of screening for open angle glaucoma: a systematic review and economic evaluation

The clinical effectiveness and cost-effectiveness of screening for open angle glaucoma: a systematic review and economic evaluation

Assessment of rates of structural change in glaucoma using imaging technologies

Surveillance for ocular hypertension: an evidence synthesis and economic evaluation

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