European Association of Urology biochemical recurrence risk groups after radical prostatectomy: External validation and identification of independent risk factors for progression and death

Sutil, Raquel Sopeña; Vázquez-Martul, D.; Pablos-Rodríguez, Pedro de; Vallejo, E. Peña; Fernandez, Celina; Lozano, A. Gómez-Ferrer; Tobar, J. Téigell; Prieto, G. Rollón; García, A. Coy; Backhaus, M. Ramírez; Abal, Venancio Chantada; Antolín, Alfredo Rodríguez

doi:10.1016/j.acuroe.2023.02.001

Cited by 2 publications

(1 citation statement)

References 24 publications

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“…The restaging PSMA PET/CTs showed heterogeneity in the EAU BCR risk groups, confirming the findings of three other studies [ 20 , 21 , 22 ]. A fourth study reported that 427 of 2140 (32%) Spanish RP patients had BCR [ 23 ], without the mortality being markedly different between the EAU BCR low- and high-risk patients.…”

Section: Discussionmentioning

confidence: 99%

Pretest PSA and Restaging PSMA PET/CT Predict Survival in Biochemically Recurrent Prostate Cancer

von Eyben,

Hoffmann,

Soydal

et al. 2023

Biomedicines

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Background: A biochemical recurrence (BCR) risk model was created based on pretest prostate specific antigen (PSA) and groupings by restaging prostate specific membrane antigen (PSMA) PET/CT. Methods: A cohort of 1216 BCR patients were analyzed for overall survival (OS) according to the PSA threshold and restaging PSMA PET/CT. A Cox regression analysis of OS was carried out to detect significant clinical characteristics. Results: In the cohort, 271 patients had a pretest PSA of <0.5 ng/mL and 945 patients had higher PSA values. The restaging PSMA PET/CT was positive for 834 patients and negative for 369. Of 1203 patients, 133 (11%) died, including 19 of the 369 (5%) patients without positive sites on the restaging PSMA PET/CT, 82 of the 711 (12%) with 1–5 positive sites, and 32 of the 123 (26%) with >5 positive sites. In the Cox regression analysis, four variables significantly predicted OS: treatment center, International Society of Urologic Pathology (ISUP) grade, pretest PSA threshold, and the grouping of positive sites on the restaging PSMA PET/CT. Conclusions: The pretest PSA and PSMA PET/CT were important for the OS of the BCR patients. The findings argue for the new BCR risk model and serve as framework for ongoing trials.

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