European Association for Neuro-Oncology (EANO) guidelines for palliative care in adults with glioma

Pace, Andrea; Dirven, Linda; Koekkoek, Johan A F; Golla, Heidrun; Fleming, Jane; Rudà, Roberta; Marosi, Christine; Rhun, Émilie Le; Grant, Robin; Oliver, Kathy; Oberg, Ingela; Bulbeck, Helen; Rooney, Alasdair G; Henriksson, Roger; Pasman, H. Roeline W.; Oberndorfer, Stefan; Weller, Michael; Taphoorn, Martin J.B.

doi:10.1016/s1470-2045(17)30345-5

Cited by 224 publications

(208 citation statements)

References 93 publications

Supporting

Mentioning

184

Contrasting

Unclassified

Order By: Relevance

“…Previous studies reported that gliomas may significantly impair cognitive functions (Derks et al, ; Liu et al, ; Noll et al, ; Pace et al, ; van Kessel, Baumfalk, van Zandvoort, Robe, & Snijders, ). Notably, significant differences were found in math exam test, DSST, mapping test, and similarity test between HCs and in patients with glioma before surgery, which was partially consistent with previous studies.…”

Section: Discussionmentioning

confidence: 98%

Restructuring of contralateral gray matter volume associated with cognition in patients with unilateral temporal lobe glioma before and after surgery

Yang

et al. 2019

Human Brain Mapping

View full text Add to dashboard Cite

Glioma can cause variable alterations to the structure and function of the brain. However, there is a paucity of studies on the gray matter (GM) volume alterations in the brain region opposite the temporal glioma before and after surgery. Therefore, the present study was initiated to investigate the alternation in contralateral homotopic GM volume in patients with unilateral temporal lobe glioma and further, assess the relationship between GM volume alternations with cognition. Eight left temporal lobe glioma patients (LTPs), nine right temporal lobe glioma patients (RTPs), and 28 demographically matched healthy controls (HCs) were included. Using voxel‐based morphometry method, alternations in the contralateral homotopic GM volume in patients with unilateral temporal lobe glioma was determined. Furthermore, the correlation analysis was performed to explore the relationship between cognitive function and altered GM volume. In the preoperative analysis, compared to HCs, LTPs exhibited increased GM volume in right inferior temporal gyrus and right temporal pole (superior temporal gyrus), and, RTPs presented increased GM volume in left inferior temporal gyrus. In the postoperative analysis, compared to HCs, RTPs presented increased GM volume in left middle temporal gyrus. Furthermore, the increased GM volume was significantly positively correlated with the memory test but negatively correlated with the visuospatial test. This study preliminarily confirmed that there were compensatory changes in the GM volume in the contralateral temporal lobe in unilateral temporal lobe glioma patients. Furthermore, alterations of GM volume may be a mechanism for cognitive function compensation.

show abstract

Section: Discussionmentioning

confidence: 98%

Restructuring of contralateral gray matter volume associated with cognition in patients with unilateral temporal lobe glioma before and after surgery

Yang

et al. 2019

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

“…The need for supportive‐care interventions—broadly defined in this review as psychosocial/behavioral, pharmacological, complementary, or alternative interventions—to improve HRQoL among brain tumor patients has been emphasized and noted as an important and emerging area . To date, three reviews have considered supportive‐care interventions in patients with brain tumors .…”

Section: Introductionmentioning

confidence: 99%

“…Of note, using a scoring system for mixed methods research and mixed studies reviews, the authors of this review concluded that the majority of the studies that they reviewed only met 33.3/100 of the quality criteria. In 2017, the European Association for Neuro‐Oncology (EANO) published guidelines for palliative care in adults with glioma . These guidelines were developed based on a comprehensive and systematic review of the literature yielding 251 included studies.…”

Section: Introductionmentioning

confidence: 99%

“…The remainder of the supported treatment recommendations were based on low‐quality evidence or expert opinion. Overall, these reviews highlight the need for more high‐quality supportive‐care intervention studies to help inform the evidence base and improve the care of patients with primary brain tumors and/or their caregivers.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, both Kangas and Piil et al only included nonpharmacologic supportive treatments, which limits the information providers have about the efficacy of a range of supportive‐care interventions, and Kangas did not rate the quality of the studies included in the review, which is necessary for informing clinical practice and guiding future research. The EANO guidelines are much more comprehensive, yet they are limited to patients with glioma and did not specifically consider HRQoL outcomes. Therefore, there is a need to capture and evaluate the quality of a broader range of supportive‐care interventions that have been thoroughly evaluated via an RCT to improve HRQoL among patients with brain tumors specifically.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Patient‐reported health‐related quality of life outcomes in supportive‐care interventions for adults with brain tumors: A systematic review

et al. 2018

View full text Add to dashboard Cite

Objectives The objectives of this systematic review were to (a) identify supportive‐care (psychosocial/behavioral, pharmacological, complementary, or alternative) interventions that have been evaluated via randomized controlled trials (RCTs) to improve patient‐reported health‐related quality of life (HRQoL) among adults with brain tumors, (b) evaluate the quality of the intervention studies, and (c) evaluate if developed interventions have been efficacious at improving HRQoL, as compared with control conditions in RCTs. Methods This systematic review was conducted using preferred reporting items for systematic reviews and meta‐analyses (PRISMA) guidelines. Four databases were searched for RCTs of supportive‐care interventions for adults with brain tumors, primary or metastatic, that included a patient‐reported HRQoL outcome. Quality of the included studies was assessed using the Effective Public Health Practice Project Quality Assessment Tool for Quantitative Studies. Results Ten RCTs involving 640 patients with either a primary or metastatic brain tumor investigating supportive‐care interventions with a HRQoL outcome were identified. In terms of quality, three of the studies received a “strong” rating, three received a “moderate” rating, and four of the studies received a “weak” rating. Only two of the interventions (ie, a home‐based psychosocial intervention and individualized acupuncture with standard rehabilitation) demonstrated improvements in HRQoL over control conditions. Conclusions HRQoL is of the utmost importance when treating patients with brain tumors. Yet there is a notable paucity of research to inform clinical decisions and evidence‐based practice. More high‐quality studies of interventions aimed at improving HRQoL are needed.

show abstract

Glioblastoma and Other Primary Brain Malignancies in Adults

Schaff

Mellinghoff

2023

JAMA

279

118

View full text Add to dashboard Cite

ImportanceMalignant primary brain tumors cause more than 15 000 deaths per year in the United States. The annual incidence of primary malignant brain tumors is approximately 7 per 100 000 individuals and increases with age. Five-year survival is approximately 36%.ObservationsApproximately 49% of malignant brain tumors are glioblastomas, and 30% are diffusely infiltrating lower-grade gliomas. Other malignant brain tumors include primary central nervous system (CNS) lymphoma (7%) and malignant forms of ependymomas (3%) and meningiomas (2%). Symptoms of malignant brain tumors include headache (50%), seizures (20%-50%), neurocognitive impairment (30%-40%), and focal neurologic deficits (10%-40%). Magnetic resonance imaging before and after a gadolinium-based contrast agent is the preferred imaging modality for evaluating brain tumors. Diagnosis requires tumor biopsy with consideration of histopathological and molecular characteristics. Treatment varies by tumor type and often includes a combination of surgery, chemotherapy, and radiation. For patients with glioblastoma, the combination of temozolomide with radiotherapy improved survival when compared with radiotherapy alone (2-year survival, 27.2% vs 10.9%; 5-year survival, 9.8% vs 1.9%; hazard ratio [HR], 0.6 [95% CI, 0.5-0.7]; P &lt; .001). In patients with anaplastic oligodendroglial tumors with 1p/19q codeletion, probable 20-year overall survival following radiotherapy without vs with the combination of procarbazine, lomustine, and vincristine was 13.6% vs 37.1% (80 patients; HR, 0.60 [95% CI, 0.35-1.03]; P = .06) in the EORTC 26951 trial and 14.9% vs 37% in the RTOG 9402 trial (125 patients; HR, 0.61 [95% CI, 0.40-0.94]; P = .02). Treatment of primary CNS lymphoma includes high-dose methotrexate-containing regimens, followed by consolidation therapy with myeloablative chemotherapy and autologous stem cell rescue, nonmyeloablative chemotherapy regimens, or whole brain radiation.Conclusions and RelevanceThe incidence of primary malignant brain tumors is approximately 7 per 100 000 individuals, and approximately 49% of primary malignant brain tumors are glioblastomas. Most patients die from progressive disease. First-line therapy for glioblastoma is surgery followed by radiation and the alkylating chemotherapeutic agent temozolomide.

show abstract

European Association for Neuro-Oncology (EANO) guidelines for palliative care in adults with glioma

Cited by 224 publications

References 93 publications

Restructuring of contralateral gray matter volume associated with cognition in patients with unilateral temporal lobe glioma before and after surgery

Restructuring of contralateral gray matter volume associated with cognition in patients with unilateral temporal lobe glioma before and after surgery

Patient‐reported health‐related quality of life outcomes in supportive‐care interventions for adults with brain tumors: A systematic review

Glioblastoma and Other Primary Brain Malignancies in Adults

Contact Info

Product

Resources

About