Euphorbia tirucalli L. modulates myelopoiesis and enhances the resistance of tumour-bearing mice

Valadares, Marize Campos; Carrucha, Silvia Granja; Accorsi, Walter Radamés; Queiroz, Mary L.S.

doi:10.1016/j.intimp.2005.07.013

Cited by 43 publications

(40 citation statements)

References 25 publications

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“…In vivo, one preliminary report postulated that Ehrlich tumor-bearing mice had myelosuppression and increased numbers of spleen granulocytemacrophage colony forming units. The treatment of these animals with E. tirucalli aqueous ethanolic extract (125, 250 or 500 mg/kg) through gavage daily for five days stimulated marrow myelopoiesis and reduced spleen colony formation [6].…”

Section: Introductionmentioning

confidence: 99%

Ehrlich ascites tumor-bearing mice treated with aqueous ethanol plant extract from <i>Euphorbia tirucalli</i> showed signs of systemic toxicity

Kviecinski¹,

Santos²,

Magagnin³

et al. 2017

Trop. J. Pharm Res

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Section: Introductionmentioning

confidence: 99%

Ehrlich ascites tumor-bearing mice treated with aqueous ethanol plant extract from <i>Euphorbia tirucalli</i> showed signs of systemic toxicity

Kviecinski¹,

Santos²,

Magagnin³

et al. 2017

Trop. J. Pharm Res

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“…Pre-clinical studies indicate that the plant has low toxicity in mice (Silva et al, 2007), and a considerable therapeutic index for antiviral activity (Betancur-Galvis et al, 2002). Our data suggest that the antitumor protection provided by E. tirucalli extract observed by Valadares et al (2006) may be mediated by type 1 cytokine (TNF-α and INF-γ) expression in neutrophils and lymphocytes, particularly CD4 + T lymphocytes. …”

Section: Resultsmentioning

confidence: 75%

“…Additionally, the hematopoiesis and spleen size of these animals returned to normal after treatment with the plant extract. However, this study neither conducted a cytokine analysis nor a detailed evaluation of the molecular mechanisms involved in the process (Valadares et al, 2006). In another report, treatment with plants from the Euphorbia genus changed the expression of multi-drug resistance (MDR) factors.…”

Section: Resultsmentioning

confidence: 90%

“…Euphorbia tirucalli L., Euphorbiaceae, is commonly used in popular medicine in the Jequitinhonha River Valley, one of the poorest regions of Minas Gerais, for therapeutic purposes to treat illness and tumors (Valadares et al, 2006;Betancur-Galvis et al, 2002;Lage et al, 2009). The in vivo antitumor effect of E. tirucalli has been demonstrated (Valadares et al, 2006), although the mechanisms responsible for such effect have not been investigated.…”

Section: Introductionmentioning

confidence: 99%

“…The in vivo antitumor effect of E. tirucalli has been demonstrated (Valadares et al, 2006), although the mechanisms responsible for such effect have not been investigated.…”

Section: Introductionmentioning

confidence: 99%

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The crude latex of Euphorbia tirucalli modulates the cytokine response of leukocytes, especially CD4+ T lymphocytes

Avelar¹,

Lélis²,

Avelar³

et al. 2011

Rev. bras. farmacogn.

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Abstract:The plants of the Euphorbiaceae family, especially those of the genus Euphorbia, are frequently used by Brazilian folk communities to treat a wide variety of infectious, tumoral and infl ammatory illnesses. Among the species of this genus, Euphorbia tirucalli L. is widely used in some Brazilian regions, such as the Jequitinhonha River Valley. There is evidence that the latex produced by E. tirucalli has antiviral and antitumor activities, but little is known about the mechanisms involved in these effects. It is likely that the mechanism for such activities involves leukocyte activation and cytokine production. In this work, we aimed to evaluate the production of type 1 (TNF-α and IFN-γ) and type 2 (IL-4 and IL-10) cytokines by circulating leukocyte subsets submitted to brief stimulation with the crude latex of E. tirucalli. Peripheral blood leukocytes of twenty healthy subjects were submitted to 4 h incubation with crude E. tirucalli latex diluted in dimethylsulfoxide. After the incubation period, the cells were stained with FITC-conjugated monoclonal antibodies specifi c to the cell surface receptors CD4, CD8 and CD14, and to PE-conjugated monoclonal antibodies specifi c to the cytokines TNF-α, IFN-γ, IL-4 and IL-10. The acquisition and analysis of data were performed by fl ow cytometry. The results showed a signifi cant increase (p<0.05) in the percentage of CD4 + T lymphocytes positive for the type 1 cytokines TNF-α and IFN-γ. Neutrophils and CD8 + T lymphocytes showed a mixed profi le of cytokine production, characterized by an increase in the percentage of cells expressing IFN-γ, TNF-α, and IL-10. The data indicate a predominant type 1 cytokine response. The fi ndings presented suggest that the effect popularly attributed to E. tirucalli usage may be attributed to its effect on the production of TNF-α and IFN-γ. However, the relationship between the in vitro and in vivo effects of E. tirucalli needs to be investigated.

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Attenuation of nociceptive pain and inflammatory disorders by total steroid and terpenoid fraction of Euphorbia tirucalli Linn root in experimental in vitro and in vivo model

Palit

Mukherjee

Mahanta³

et al. 2017

Inflammopharmacol

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The plant Euphorbia tirucalli Linn has been successfully used as a tribal folk medicine in India and Africa for the management of acute inflammatory, arthritic, nociceptive pain and asthmatic symptoms. The present study was conducted to assess the anti-inflammatory, analgesic, anti-asthmatic and anti-arthritic role of the total steroid and terpenoid rich fractions of the hydro-alcoholic extract of E. tirucalli root (STF-HAETR). STF-HAETR fraction demonstrated 71.25 ± 2.5 and 74.25 ± 5.1% protection against acetic acid-induced pain and central neuropathic pain at 75 and 100 mg/kg doses, respectively. It showed 96.97% protection against acute inflammation at 100 mg/kg with 1.6-fold better activity than the standard drug. The fraction exhibited such efficacy via inhibition of proinflammatory cytokines TNF-α, IFN-γ, by 61.12 and 65.18%, respectively, at 100 μg/mL. Inhibition of cyclooxygenase and Nitric oxide synthase in a dose-dependent manner affirms its analgesic and anti-inflammatory activity. The spectrophotometric analysis reveals that STF-HAETR induces ameliorative effect against heat-induced denaturation of Bovine serum albumin (BSA) and exhibits significant anti-proteinase activity. The plant fraction also demonstrated anti-asthmatic activity by displaying 62.45% protection against histamine induced bronchoconstriction or dyspnoea. Our findings suggest that STF-HAETR could be an effective safe therapeutic agent to treat nociceptive pain, acute inflammation, asthma, and arthritis which may authenticate its traditional use.

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Euphorbia tirucalli L. modulates myelopoiesis and enhances the resistance of tumour-bearing mice

Cited by 43 publications

References 25 publications

Ehrlich ascites tumor-bearing mice treated with aqueous ethanol plant extract from <i>Euphorbia tirucalli</i> showed signs of systemic toxicity

Ehrlich ascites tumor-bearing mice treated with aqueous ethanol plant extract from <i>Euphorbia tirucalli</i> showed signs of systemic toxicity

The crude latex of Euphorbia tirucalli modulates the cytokine response of leukocytes, especially CD4+ T lymphocytes

Attenuation of nociceptive pain and inflammatory disorders by total steroid and terpenoid fraction of Euphorbia tirucalli Linn root in experimental in vitro and in vivo model

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