Euphol from Euphorbia tirucalli selectively inhibits human gastric cancer cell growth through the induction of ERK1/2-mediated apoptosis

Lin, Ming; Lin, An Shen; Wu, Deng Chyang; Wang, Sophie S.W.; Chang, Fang Rong; Wu, Yang Chang; Huang, Yaw‐Bin

doi:10.1016/j.fct.2012.05.029

Cited by 73 publications

(53 citation statements)

References 47 publications

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“…However, literature is still lacking in vivo data and safety data. One study has shown that euphol, a triterpene from E. tirucalli inhibited the growth of gastric cancer cells by ERK 1/2-mediated apoptosis [5]. In vivo, one preliminary report postulated that Ehrlich tumor-bearing mice had myelosuppression and increased numbers of spleen granulocytemacrophage colony forming units.…”

Section: Introductionmentioning

confidence: 99%

Ehrlich ascites tumor-bearing mice treated with aqueous ethanol plant extract from <i>Euphorbia tirucalli</i> showed signs of systemic toxicity

Kviecinski¹,

Santos²,

Magagnin³

et al. 2017

Trop. J. Pharm Res

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Section: Introductionmentioning

confidence: 99%

Ehrlich ascites tumor-bearing mice treated with aqueous ethanol plant extract from <i>Euphorbia tirucalli</i> showed signs of systemic toxicity

Kviecinski¹,

Santos²,

Magagnin³

et al. 2017

Trop. J. Pharm Res

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“…The crude latex from E. tirucalli is used in traditional medicine [3,5,29] for the treatment of several types of cancer [5,6]. In the present study, no significant differences were found between the different substances used regarding the anticarcinogenic effect on the oral mucosa after 13 and 20 weeks.…”

Section: Discussionmentioning

confidence: 34%

“…Each cage was lined with wood shavings, contained a maximum of five animals and was cleaned twice per week. The animals were individually weighed at 3,5,7,9,11,13,15,17,19 and 20 weeks using an analytical scale (Gehaka®, model BG 440).…”

Section: Sample and Experimental Groupsmentioning

confidence: 99%

“…However, studies have reported the toxicity of this latex to skin and mucous membranes [13,14] due to the presence of phorbol esters in species of the family Euphorbiaceae [5,15]. As there is controversy regarding the anticarcinogenic effects and modulatory activity of the latex from E. tirucalli in cases of carcinogenesis [16][17][18]34], studies are needed to demonstrate its activity.…”

Section: Introductionmentioning

confidence: 99%

“…The latex from this species is commonly used in traditional medicine [3] for the treatment of cancer [2,[4][5][6][7]. This substance is also reported to have immunomodulatory [7,8], analgesic [9], angiogenic [10], antimicrobial [11], antimutagenic and antirheumatic [12] properties.…”

Section: Introductionmentioning

confidence: 99%

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Effect of crude latex from Euphorbia tirucalli on DMBA-induced carcinogenesis

Barroso¹,

Verli²,

Rocha³

et al. 2017

J Histol Histopathol

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Background: The aim of the present study was to determine the action of crude latex from Euphorbia tirucalli dissolved in DMSO in animal models of DMBA-induced carcinogenesis. Methods: Three groups of hamsters received a topical application on edge of the tongue: 1) 0.5% DMBA+crude latex from E. tirucalli in 10% DMSO; 2) 0.5% DMBA+10% DMSO; and 3) 0.5% DMBA+saline solution. Macroscopic and histopathological analyses of the tumors were performed and antibodies were quantified using ELISA after 13 and 20 weeks of treatment. Results: No statistically significant association was found between the development of cancer of the tongue mucosa and the production of antibodies in the different groups. Conclusions: Although the data were non-significant, crude latex from E. tirucalli seems to reduce the aggressiveness and size of lesions, but further tests are required.

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Quantitative determination of euphol in rat plasma by LC‐MS/MS and its application to a pharmacokinetic study

Xie

Gao

et al. 2014

Biomedical Chromatography

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Euphol is a potential pharmacologically active ingredient isolated from Euphorbia kansui. A simple, rapid, and sensitive method to determine euphol in rat plasma was developed based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the first time. The analyte and internal standard (IS), oleanic acid, were extracted from plasma with methanol and chromatographied on a C18 short column eluted with a mobile phase of methanol–water–formic acid (95:5:0.1, v/v/v). Detection was performed by positive ion atmospheric pressure chemical ionization in selective reaction monitoring mode. This method monitored the transitions m/z 409.0 →109.2 and m/z 439.4 → 203.2 for euphol and IS, respectively. The assay was linear over the concentration range 27–9000 ng/mL, with a limit of quantitation of 27 ng/mL. The accuracy was between –7.04 and 4.11%, and the precision was <10.83%. This LC-MS/MS method was successfully applied to investigate the pharmacokinetic study of euphol in rats after intravenous (6 mg/kg) and oral (48 mg/kg) administration. Results showed that the absolute bioavailability of euphol was approximately 46.01%.

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Euphol from Euphorbia tirucalli selectively inhibits human gastric cancer cell growth through the induction of ERK1/2-mediated apoptosis

Cited by 73 publications

References 47 publications

Ehrlich ascites tumor-bearing mice treated with aqueous ethanol plant extract from <i>Euphorbia tirucalli</i> showed signs of systemic toxicity

Ehrlich ascites tumor-bearing mice treated with aqueous ethanol plant extract from <i>Euphorbia tirucalli</i> showed signs of systemic toxicity

Effect of crude latex from Euphorbia tirucalli on DMBA-induced carcinogenesis

Quantitative determination of euphol in rat plasma by LC‐MS/MS and its application to a pharmacokinetic study

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