Euphatexols C − G, five new triterpenoids from the latex of <i>Euphorbia resinifera</i>

Li, Miaomiao; Qi, Yan-Ru; Feng, Ya‐Ping; Liu, Wei; Yuan, Tao

doi:10.1080/10286020.2021.1935894

Cited by 4 publications

(11 citation statements)

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“…Several studies have shown that extracts of E. resinifera, especially latex extract, contain many chemical compositions [16,21,25,[46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61]. Table 2 summarizes the class of bioactive compounds, the plant organ, the country of origin, and the most abundant compounds of E. resinifera, namely terpenoids.…”

Section: Phytochemistrymentioning

confidence: 99%

“…Moreover, Ourhzif et al isolated euphorbioside monohydrate (Euphorbioside C) from the latex of this plant (Azilal, Morocco) using a single-crystal X-ray structure, NMR, LC/HRMS, and IR spectra [59]. In addition, Li et al identified five new tritepenoids named as euphatexols (C-G) from the ethanol extract of Euphorbium (Xinjiang, China) using a group of spectroscopic methods (IR, HRMS, 1D, and 2D NMR data) [52]. The same authors isolated 3β-hydroxy-12α-methoxy-24-methylene-lanost-7,9(11)-dien; 3βhydroxy-12α-methoxylanosta-7,9(11),24-triene; 3,7-dioxo-24-methylene-lanost-8-en; and 3,7-dioxo-lanosta-8,24-diene (new lanostane triterpenoids) from the latex of E. resinifera using several chromatography methods [51].…”

Section: Terpenoidsmentioning

confidence: 99%

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Ethnomedicinal Use, Phytochemistry, Pharmacology, and Toxicology of Euphorbia resinifera O. Berg. (B): A Review

Hmidouche

Bouftini

Chafik

et al. 2023

JZBG

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Euphorbia resinifera (Zaggûm or Tikiut) is an endemic species of Morocco that grows in the Middle Atlas Mountain range. It is used in folk medicine to treat several diseases, especially various types of cancer. Aim of the review: In this review, we critically highlighted and discussed previous reports on E. resinifera, concerning its botanical description, taxonomy, geographical distribution, and medicinal use. In addition, bioactive compounds, toxicology, and pharmacological effects were reported. Materials and methods: We searched various scientific databases, such as Scopus, PubMed, Web of Science, SpringerLink, SciFinder, Wiley Online, and Google Scholar, to collect data on E. resinifera. Studies involving E. resinifera or its bioactive compounds with regards to antitumor, anti-inflammatory, antileishmanial, antiprotease, immunomodulatory, irritant, and lysosomal activities are discussed here. Results: E. resinifera has been widely used in folk medicine practice in Morocco to treat several diseases such as diabetes, cancer, and inflammatory skin conditions, as well as to heal wounds. In phytochemistry studies, biochemical compounds have been identified from E. resinifera belonging specially to terpenoids. Indeed, in vitro and in vivo pharmacological investigations showed that extracts and compounds from the latex of E. resinifera exhibited a wide spectrum of biological properties, particularly antioxidant, antimicrobial, antitumor, anti-inflammatory, antileishmanial, and immunomodulatory and neuroprotective activities. Conclusion: The use of E. resinifera in conventional medicine is supported by processes founded on biological evidence. However, in-depth research is necessary to prove the safety and efficacy of E. resinifera latex extracts and their compounds and to clarify their pharmacological mechanisms. In addition, pharmacokinetic and pharmacodynamics studies are required for extracts and bioactive compounds.

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Section: Phytochemistrymentioning

confidence: 99%

Section: Terpenoidsmentioning

confidence: 99%

Ethnomedicinal Use, Phytochemistry, Pharmacology, and Toxicology of Euphorbia resinifera O. Berg. (B): A Review

Hmidouche

Bouftini

Chafik

et al. 2023

JZBG

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“… Structure of chemicals compounds (70-74; 76; 78; 81) and (84-94) ( Esposito et al, 2016 ; Li et al, 2022 ). …”

Section: Terpenoidsmentioning

confidence: 99%

“…Two triterpenoids were isolated by Qi et al, compound (72) , which was reported for the first time and was shown to contain a tetrahydrofuran ring, and (73) ( Qi et al, 2019 ). Furthermore, five triterpenoids (74–78) were discovered by Li et al (2022) , and (79–82) were isolated in 2021 ( Li et al, 2021 ).…”

Section: Terpenoidsmentioning

confidence: 99%

“…3,7-dioxo-lanosta-8,24-diene (81), and 3,7-dioxo-24-methylene-lanost-8-ene (82). Resiniferatoxin (83) Fattorusso et al, 2002;Qi et al, 2019;Wang et al, 2019;Li et al, 2021Li et al, , 2022 dendroides Euphodendroidins E (84), euphodendroidins F (85), Euphodendroidin J (2R,3R,4S,5R,7R,8R,9R,13S,15R)-8,9-Diacetoxy-2,5,15-trihydroxy-3,7dibenzoyloxy-14-oxojatropha-6(17), 11Ediene (86), euphodendroidins A (87), Euphodendroidin K, (2R,3R,4S,5R,7R,8R,9R,13S,15R)-2,8,9-Triacetoxy-15hydroxy-7-benzoyloxy-3,5-diisobutyroyloxy-14-oxojatropha-6(17),11E-diene (88), Euphodendroidin L (2R,3R,4S,5R,7R,8R,9R,13S,15R)-2,3,8,9-Tetracetoxy-15-hydroxy-7-benzoyloxy-5-isobutyroyloxy-14-oxojatropha-6(17 17),11E-diene-14-one (110), 2a,5a,8a-triacetyloxy-15b-hydroxy-7bisobutanoyloxy-9a-nicotinyloxy-3b-propanoyloxyjatropha-6 (17),11E-diene-14-one (111), 5a,8a,9a-triacetyloxy-15b-hydroxy-3b,7bdiisobutanoyloxy-2a-nicotinyloxyjatropha-6 (17),11Ediene-14-one (112), 5a,8a,9a-triacetyloxy-15b-hydroxy-7b-isobutanoyloxy-2a-nicotinyloxy-3bpropanoyloxyjatropha-6 (17),11E-diene-14-one (113), euphodendrophane O (114),5a,7 b,15b-triacetyloxy-9a-nicotinyloxy-3b-propanoyloxyjatropha-6 (17),11Ediene-14-one (115), 3b,5a,8a,15b-tetraacetyloxy-9anicotinyloxy-7b-isobutanoyloxyjatropha-6 (17),11E-diene-14-one (116), 5a,9adiacetyloxy-15b-hydroxy-7b-isobutanoyloxy-8a-nicotinyloxy-3bpropanoyloxyjatropha-6 (17),11E-diene-14-one (117), euphodendrophanes A (118), B(119), C (120), N (121), F (122), Q(123)and S (124) 3S,24S)-tirucall-7-ene-3,24,25-triol (125), (3S,24R)-tirucall-7-ene-3,24,25-triol (126) and inoterpene C (127). Krstić et al, 2018, 2019…”

Section: Species Compounds Referencesmentioning

confidence: 99%

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Euphorbia species latex: A comprehensive review on phytochemistry and biological activities

et al. 2022

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The genus Euphorbia includes about 2,000 species commonly widespread in both temperate and tropical zones that contain poisonous milky juice fluid or latex. Many species have been used in traditional and complementary medicine for the treatment of various health issues such as dropsy, paralysis, deafness, wounds, warts on the skin, and amaurosis. The medicinal applications of these species have been attributed to the presence of various compounds, and most studies on Euphorbia species have focused on their latex. In this review, we summarize the current state of knowledge on chemical composition and biological activities of the latex from various species of the genus Euphorbia. Our aim was to explore the applications of latex extracts in the medical field and to evaluate their ethnopharmacological potential. The databases employed for data collection, are obtained through Web of Science, PubMed, Google Scholar, Science Direct and Scopus, from 1983 to 2022. The bibliographic data indicate that terpenoids are the most common secondary metabolites in the latex. Furthermore, the latex has interesting biological properties and pharmacological functions, including antibacterial, antioxidant, free radical scavenger, cytotoxic, tumor, anti-inflammatory, healing, hemostatic, anti-angiogenic, insecticidal, genotoxic, and mutagenic activities. However, the role of other components in the latex, such as phenolic compounds, alkaloids, saponins, and flavonoids, remains unknown, which limits the application of the latex. Future studies are required to optimize the therapeutic use of latex extracts.

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Two spurge species, Euphorbia resinifera O. Berg and Euphorbia officinarum subsp. echinus (Hook.f. & Coss.) Vindt inhibit colon cancer

Benjamaa,

Zhu,

Kim

et al. 2024

BMC Complement Med Ther

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Background Colon cancer, a prominent contributor to global cancer-related deaths, prompts the need for innovative treatment strategies. Euphorbia resinifera O. Berg (E. resinifera) and Euphorbia officinarum subsp. echinus Hook. f. & Coss Vindt (E. echinus) and their bee-derived products have been integral to traditional Moroccan medicine due to their potential health benefits. These plants have historical use in addressing various health issues, including cancer. However, their effects against colon cancer remain unclear, and the specific mechanisms underlying their anti-cancer effects lack comprehensive investigation. Methods The study aimed to assess the potential anti-cancer effects of Euphorbia extract on colon cancer cell lines (DLD-1) through various techniques. The apoptosis, migration, and proliferation of DLD-1 cells were measured in DLD-1 cells. In addition, we conducted High-Performance Liquid Chromatography (HPLC) analysis to identify the profile of phenolic compounds present in the studied extracts. Results The extracts demonstrated inhibition of colon cancer cell migration. E. resinifera flower and E. echinus stem extracts show significant anti-migratory effects. Regarding anti-proliferative activity, E. resinifera flower extract hindered proliferation, whereas E. echinus flower extract exhibited dose-dependent inhibition. Apoptosis assays revealed E. resinifera flower extract inducing early-stage apoptosis and E. echinus flower extract promoting late-stage apoptosis. While apoptotic protein expression indicated, E. resinifera stem and propolis extracts had minimal impact on apoptosis. Conclusion The findings provide evidence supporting the beneficial effects of E resinifera and E. echinus extracts on colon cancer and exerting anti-cancer properties.

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Euphatexols C − G, five new triterpenoids from the latex of Euphorbia resinifera

Cited by 4 publications

References 12 publications

Ethnomedicinal Use, Phytochemistry, Pharmacology, and Toxicology of Euphorbia resinifera O. Berg. (B): A Review

Ethnomedicinal Use, Phytochemistry, Pharmacology, and Toxicology of Euphorbia resinifera O. Berg. (B): A Review

Euphorbia species latex: A comprehensive review on phytochemistry and biological activities

Two spurge species, Euphorbia resinifera O. Berg and Euphorbia officinarum subsp. echinus (Hook.f. & Coss.) Vindt inhibit colon cancer

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