Eupatilin Ameliorates Lipopolysaccharide-Induced Acute Kidney Injury by Inhibiting Inflammation, Oxidative Stress, and Apoptosis in Mice
Kiryeong Kim,
Hyo-Lim Hong,
Gyun Moo Kim
et al.
Abstract:Acute kidney injury (AKI) is a common complication of sepsis. Eupatilin (EUP) is a natural flavone with multiple biological activities and has beneficial effects against various inflammatory disorders. However, whether EUP has a favorable effect on septic AKI remains unknown. Here, we examined the effect of EUP on lipopolysaccharide (LPS)-evoked AKI in mice. LPS-evoked renal dysfunction was attenuated by EUP, as reflected by reductions in serum creatinine and blood urea nitrogen levels. LPS injection also indu… Show more
“…LPS-treated mice were also inhibited by EUP in p53-mediated apoptosis. Hence, EUP inhibits oxidative stress, inflammation, and apoptosis, thereby ameliorating LPS-induced AKI [ 9 ].…”
“…LPS-treated mice were also inhibited by EUP in p53-mediated apoptosis. Hence, EUP inhibits oxidative stress, inflammation, and apoptosis, thereby ameliorating LPS-induced AKI [ 9 ].…”
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.