Euonymus alatus (Thunb.) Sieb induces apoptosis via mitochondrial pathway as prooxidant in human uterine leiomyomal smooth muscle cells

Kim, C.-H.; Kim, D.-I.; Kwon, Chong-Suk; Kang, Suk‐Ku; Jin, Un‐Ho; Suh, Suk-Jong; Lee, T.-K.; Lee, I.-S.

doi:10.1111/j.1525-1438.2006.00524.x

Cited by 15 publications

(8 citation statements)

References 27 publications

(29 reference statements)

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“…SB contains high levels of both alkaloids and flavone compounds (47). EA is a traditional Korean medicine that has be used as an anti-tumor agent in both Korea and China (48). EA is known to contain a variety of flavonoids, cardenolides, caffeic acid (48) and recently quercetin and rutin were extracted from this plant (49).…”

Section: Herbal Extractsmentioning

confidence: 99%

“…EA is a traditional Korean medicine that has be used as an anti-tumor agent in both Korea and China (48). EA is known to contain a variety of flavonoids, cardenolides, caffeic acid (48) and recently quercetin and rutin were extracted from this plant (49). Extracts of both of these herbs were tested in aromatase expressing myometrial and leiomyomal cells and also in human placental tissue.…”

Section: Herbal Extractsmentioning

confidence: 99%

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Phytochemicals for breast cancer prevention by targeting aromatase

Adams

Chen²

2009

Front Biosci

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Aromatase is a cytochrome P450 enzyme (CYP19) and is the rate limiting enzyme in the conversion of androgens to estrogens. Suppression of in situ estrogen production through aromatase inhibition is the current treatment strategy for hormone-responsive breast cancers. Drugs that inhibit aromatase have been developed and are currently utilized as adjuvant therapy for breast cancer in post-menopausal women with hormone dependent breast cancer. Natural compounds have been studied extensively for important biologic effects such as antioxidant, anti-tumor and anti-viral effects. A significant number of studies have also investigated the aromatase inhibitory properties of a variety of plant extracts and phytochemicals. The identification of natural compounds that inhibit aromatase could be useful both from a chemopreventive standpoint and in the development of new aromatase inhibitory drugs. This review will discuss whole food extracts and the common classes of phytochemicals which have been investigated for potential aromatase inhibitory activity. We will review reported aromatase inhibition, kinetic data and possible structural variations that may inhibit or enhance the interaction of phytochemicals with the aromatase enzyme.

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Section: Herbal Extractsmentioning

confidence: 99%

Section: Herbal Extractsmentioning

confidence: 99%

Phytochemicals for breast cancer prevention by targeting aromatase

Adams

Chen²

2009

Front Biosci

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“…Similarly, anti-cancer activities of S. barbata, E. alatus, and isoliquiritigenin, the latter a component of S. suberectus, have been determined by induction of cell apoptosis via caspase-3 activation in uterine leiomyomal smooth muscle cells (Lee et al, 2005;Kim et al, 2006Kim et al, , 2008aKim et al, , 2008b. C. zedoaria has also been reported as beneficial in the treatment of uterine cervical neoplasia (Moura et al, 2002).…”

Section: Discussionmentioning

confidence: 95%

Effect of different ingredients in traditional Korean medicine for human uterine leiomyoma on normal myometrial and leiomyomal smooth muscle cell proliferation

Bajracharya

Lee

et al. 2009

Arch. Pharm. Res.

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Crude water extracts of 13 traditional Korean medicinal ingredients used for leiomyomal treatment were prepared and used to treat human uterine normal myometrial and leiomyomal cell cultures. All the ingredients inhibited proliferation and altered the morphology of both myometrial and leiomyomal cells. Among the 13 ingredients, n-hexane-, chloroform-, and ethylacetate-soluble fractions were extracted from seven ingredients that potently inhibited cell proliferation in their water extract form. Among these, the ethylacetate-fraction of Phlomis umbrosa and Spatholobus suberectus, and the chloroform-fraction of Curcuma zedoaria and S. suberectus inhibited leiomyomal cell proliferation significantly compared to myometrial cell proliferation. Similarly, immunohistochemical analysis showed the inhibition of transforming growth factor-beta receptor 2 in leiomyomal tissue after treatment with the fractions of the ingredients. Moreover, the chloroform-fraction of C. zedoaria was subfractionated by open column chromatography. Two of the eight subfractions (fractions 6 and 7) potently inhibited cell proliferation in leiomyoma compared to myometrium. Further study will be performed with the goal of isolating specific compounds from two effective subfractions of C. zedoaria, ethylacetate-fraction of P. umbrosa, and the ethylacetate and chloroform-fractions of S. suberectus. The present study may be helpful in developing an alternative remedy to leiomyoma with minimal side-effects compared to the current treatments.

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“…Euonymus alatus , known as ' gui-jun woo ' in Korea, has been used in Asian folk medicine to treat tumors, regulate blood circulation, and relieve pain in countries including Korea and China (Kim et al, 2006; Park et al, 2005). However, there is not enough scientific evidence to support the medical use of E. alatus .…”

Section: Introductionmentioning

confidence: 99%

Inhibitory activity ofEuonymus alatusagainst alpha-glucosidasein vitroandin vivo

et al. 2007

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The major goal in the treatment of diabetes mellitus is to achieve near-normal glycemic control. To optimize both fasting blood glucose and postprandial glucose levels is important in keeping blood glucose levels as close to normal as possible. α-Glucosidase is the enzyme that digests dietary carbohydrate, and inhibition of this enzyme could suppress postprandial hyperglycemia. The purpose of this study was to test the inhibitory activity of methanol extract of Euonymus alatus on α-glucosidase in vitro and in vivo to evaluate its possible use as an anti-diabetic agent. Yeast α-glucosidase inhibitory activities of methanol extract of E. alatus were measured at concentrations of 0.50, 0.25, 0.10, and 0.05 mg/ml. The ability of E. alatus to lower postprandial glucose was studied in streptozotocin-induced diabetic rats. A starch solution (1 g/kg) with and without E. alatus extract (500 mg/kg) was administered to diabetic rats by gastric intubation after an overnight fast. Plasma glucose levels were measured at 30, 60, 90, 120, 180, and 240 min. Plasma glucose levels were expressed in increments from baseline, and incremental areas under the response curve were calculated. Extract of E. alatus,which had an IC50 value of 0.272 mg/ml, inhibited yeast α-glucosidase activity in a concentration-dependent manner. A single oral dose of E. alatus extract significantly inhibited increases in blood glucose levels at 60 and 90 min (p<0.05) and significantly decreased incremental response areas under the glycemic response curve (p<0.05). These results suggest that E. alatus has an antihyperglycemic effect by inhibiting α-glucosidase activity in this animal model of diabetes mellitus.

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Euonymus alatus (Thunb.) Sieb induces apoptosis via mitochondrial pathway as prooxidant in human uterine leiomyomal smooth muscle cells

Cited by 15 publications

References 27 publications

Phytochemicals for breast cancer prevention by targeting aromatase

Phytochemicals for breast cancer prevention by targeting aromatase

Effect of different ingredients in traditional Korean medicine for human uterine leiomyoma on normal myometrial and leiomyomal smooth muscle cell proliferation

Inhibitory activity ofEuonymus alatusagainst alpha-glucosidasein vitroandin vivo

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